Open Access

Interactions between dendritic cells and T lymphocytes in pathogenesis of nasal polyps

  • Authors:
    • Xinsheng Lin
    • Xiayan Zhuang
    • Chuangwei Li
    • Xin Wang
  • View Affiliations

  • Published online on: May 3, 2018     https://doi.org/10.3892/etm.2018.6128
  • Pages: 5167-5172
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the functional status of dendritic cells (DCs) in nasal polyps (NP) and their interactions with T lymphocytes. The interactions between DC and T lymphocytes in the pathogenesis of NP was also studied. The expression of cluster of differentiation (CD)1a and CD83 in NP was detected using immunohistochemistry and the ratio of CD83 DC/CD1a+DC was counted. The distribution of DCs in NP and normal inferior turbinate mucosa (nITM) was evaluated using double immunostaining (CD1a/CD40) and low illumination fluorescence microscopy. The number of CD1a+ cells, CD83+ cells and CD1a/CD40‑dual positive cells in was significantly higher in NP tissues compared with nITM. Furthermore, the density of DCs observed in NP was significantly greater than that observed in nITM. The ratio of CD83 DC/CD1a+DC in NP was significantly higher compared with in nITM tissues. The results of the present study revealed significant infiltration of DCs in NP, with the majority being mature DCs. DCs are able to interact with T cells via the CD40/CD40L costimulatory factor, thus serving an important role in the development and progression of NP.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Lin X, Zhuang X, Li C and Wang X: Interactions between dendritic cells and T lymphocytes in pathogenesis of nasal polyps. Exp Ther Med 15: 5167-5172, 2018
APA
Lin, X., Zhuang, X., Li, C., & Wang, X. (2018). Interactions between dendritic cells and T lymphocytes in pathogenesis of nasal polyps. Experimental and Therapeutic Medicine, 15, 5167-5172. https://doi.org/10.3892/etm.2018.6128
MLA
Lin, X., Zhuang, X., Li, C., Wang, X."Interactions between dendritic cells and T lymphocytes in pathogenesis of nasal polyps". Experimental and Therapeutic Medicine 15.6 (2018): 5167-5172.
Chicago
Lin, X., Zhuang, X., Li, C., Wang, X."Interactions between dendritic cells and T lymphocytes in pathogenesis of nasal polyps". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5167-5172. https://doi.org/10.3892/etm.2018.6128