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Article

Analysis of clinical risk factors in relapsed patients with class IV lupus nephritis

  • Authors:
    • Jing Wang
    • Yuan‑Yuan Qi
    • Xue‑Ping Chen
    • Li Ma
    • Li‑Li Zhang
    • Yu Zhao
    • Mei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Nephropathy, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, P.R. China, Department of Obstetrics and Gynecology, Gansu Province People's Hospital, Lanzhou, Gansu 730000, P.R. China
  • Pages: 5461-5468
    |
    Published online on: May 3, 2018
       https://doi.org/10.3892/etm.2018.6130
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Abstract

The present study aimed to investigate risk factors for renal recurrence in patients with type IV lupus nephritis (LN). Univariate and multivariate analyses were conducted to using the Cox proportional hazard model and the Kaplan‑Meier method. A total 244 patients were diagnosed with type IV LN; 100 (28.49%) relapsed and 144 (41.03%) recovered successfully. Kaplan‑Meier method analysis indicated that patients with type IV LN affecting the digestive tract had high renal recurrence rates. Patients with hyperglobulinemia, positive anti‑ribonucleoprotein and anti‑Sjögren's syndrome type B (anti‑SSB) antibodies, thrombus in the loop or non‑inflammatory necrotizing vasculopathy also had a high recurrence rate. Furthermore, patients achieving partial remission had an increased recurrence rate compared with patients achieving complete remission. Patients undergoing maintenance treatment with glucocorticoids alone had a higher recurrence rate compared with patients who used alternative treatment schemes. Univariate and multivariate regression analyses by the Cox proportional hazard model determined that the effect of systemic lupus erythematosus in the gastrointestinal tract, increased serum globulin levels and positive anti‑SSB antibody at onset were risk factors for the recurrence of LN type IV. The present study demonstrated that clinical risk factors of renal recurrence in patients with LN type IV include LN in the gastrointestinal tract, increased serum globulin levels, positive anti‑SSB antibodies at onset and the use of glucocorticoid‑only maintenance treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Qi YY, Chen XP, Ma L, Zhang LL, Zhao Y and Wang M: Analysis of clinical risk factors in relapsed patients with class IV lupus nephritis. Exp Ther Med 15: 5461-5468, 2018.
APA
Wang, J., Qi, Y., Chen, X., Ma, L., Zhang, L., Zhao, Y., & Wang, M. (2018). Analysis of clinical risk factors in relapsed patients with class IV lupus nephritis. Experimental and Therapeutic Medicine, 15, 5461-5468. https://doi.org/10.3892/etm.2018.6130
MLA
Wang, J., Qi, Y., Chen, X., Ma, L., Zhang, L., Zhao, Y., Wang, M."Analysis of clinical risk factors in relapsed patients with class IV lupus nephritis". Experimental and Therapeutic Medicine 15.6 (2018): 5461-5468.
Chicago
Wang, J., Qi, Y., Chen, X., Ma, L., Zhang, L., Zhao, Y., Wang, M."Analysis of clinical risk factors in relapsed patients with class IV lupus nephritis". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5461-5468. https://doi.org/10.3892/etm.2018.6130
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Qi YY, Chen XP, Ma L, Zhang LL, Zhao Y and Wang M: Analysis of clinical risk factors in relapsed patients with class IV lupus nephritis. Exp Ther Med 15: 5461-5468, 2018.
APA
Wang, J., Qi, Y., Chen, X., Ma, L., Zhang, L., Zhao, Y., & Wang, M. (2018). Analysis of clinical risk factors in relapsed patients with class IV lupus nephritis. Experimental and Therapeutic Medicine, 15, 5461-5468. https://doi.org/10.3892/etm.2018.6130
MLA
Wang, J., Qi, Y., Chen, X., Ma, L., Zhang, L., Zhao, Y., Wang, M."Analysis of clinical risk factors in relapsed patients with class IV lupus nephritis". Experimental and Therapeutic Medicine 15.6 (2018): 5461-5468.
Chicago
Wang, J., Qi, Y., Chen, X., Ma, L., Zhang, L., Zhao, Y., Wang, M."Analysis of clinical risk factors in relapsed patients with class IV lupus nephritis". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5461-5468. https://doi.org/10.3892/etm.2018.6130
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