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Article

Experimental study of epidermal growth factor and acidic fibroblast growth factor in the treatment of diabetic foot wounds

  • Authors:
    • Jiasheng Xu
    • Dinghong Min
    • Guanghua Guo
    • Xincheng Liao
    • Zhonghua Fu
  • View Affiliations / Copyright

    Affiliations: Burn Center, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330001, P.R. China
  • Pages: 5365-5370
    |
    Published online on: May 3, 2018
       https://doi.org/10.3892/etm.2018.6131
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Abstract

The aim of the present study was to investigate the effect of epidermal growth factor (EGF) and acidic fibroblast growth factor (aFGF) on the healing of diabetic foot wounds. A total of 199 patients with diabetic foot ulcers were recruited and randomly divided into four groups: A recombinant human EGF group (n=50), an aFGF group (n=50), a combined EGF and aFGF group (n=50) and a normal saline control group (n=49). Patients in all groups received a daily dressing change and growth factor reagents were applied topically when dressing. To observe the time required for each stage of wound healing, the epidermal healing rate and granulation tissue growth were recorded. Following 3‑4 days of treatment, the wound healing stage was similar in all groups. Later stages (following 4 days) of wound healing were achieved significantly faster in the combined group compared with the control group (P<0.05). The rate of wound healing in the EGF group was similar to that observed in the combination group. No significant difference was observed between the EGF and aFGF groups during the initial period of wound healing. However, in the later stage (following 4 days), the combined use of recombinant human EGF and aFGF had a marked positive effect on wound healing when compared with the control group. Growth factors have extensive biological activities with functions including promoting cell proliferation as well as rehabilitating and regenerating tissues, which serve important roles in wound healing.
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Copy and paste a formatted citation
Spandidos Publications style
Xu J, Min D, Guo G, Liao X and Fu Z: Experimental study of epidermal growth factor and acidic fibroblast growth factor in the treatment of diabetic foot wounds. Exp Ther Med 15: 5365-5370, 2018.
APA
Xu, J., Min, D., Guo, G., Liao, X., & Fu, Z. (2018). Experimental study of epidermal growth factor and acidic fibroblast growth factor in the treatment of diabetic foot wounds. Experimental and Therapeutic Medicine, 15, 5365-5370. https://doi.org/10.3892/etm.2018.6131
MLA
Xu, J., Min, D., Guo, G., Liao, X., Fu, Z."Experimental study of epidermal growth factor and acidic fibroblast growth factor in the treatment of diabetic foot wounds". Experimental and Therapeutic Medicine 15.6 (2018): 5365-5370.
Chicago
Xu, J., Min, D., Guo, G., Liao, X., Fu, Z."Experimental study of epidermal growth factor and acidic fibroblast growth factor in the treatment of diabetic foot wounds". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5365-5370. https://doi.org/10.3892/etm.2018.6131
Copy and paste a formatted citation
x
Spandidos Publications style
Xu J, Min D, Guo G, Liao X and Fu Z: Experimental study of epidermal growth factor and acidic fibroblast growth factor in the treatment of diabetic foot wounds. Exp Ther Med 15: 5365-5370, 2018.
APA
Xu, J., Min, D., Guo, G., Liao, X., & Fu, Z. (2018). Experimental study of epidermal growth factor and acidic fibroblast growth factor in the treatment of diabetic foot wounds. Experimental and Therapeutic Medicine, 15, 5365-5370. https://doi.org/10.3892/etm.2018.6131
MLA
Xu, J., Min, D., Guo, G., Liao, X., Fu, Z."Experimental study of epidermal growth factor and acidic fibroblast growth factor in the treatment of diabetic foot wounds". Experimental and Therapeutic Medicine 15.6 (2018): 5365-5370.
Chicago
Xu, J., Min, D., Guo, G., Liao, X., Fu, Z."Experimental study of epidermal growth factor and acidic fibroblast growth factor in the treatment of diabetic foot wounds". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5365-5370. https://doi.org/10.3892/etm.2018.6131
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