Glycerol fructose combined with vitamin B6 is beneficial to postoperative recovery of patients with cerebral aneurysm

Chen,Xiya; Lei,Ting

doi:10.3892/etm.2018.6133

Glycerol fructose combined with vitamin B6 is beneficial to postoperative recovery of patients with cerebral aneurysm

Authors:
- Xiya Chen
- Ting Lei
View Affiliations

Affiliations: Department of Neurosurgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 431400, P.R. China, Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, P.R. China
Published online on: May 3, 2018 https://doi.org/10.3892/etm.2018.6133
Pages: 236-240
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The aim of the present study is to investigate whether glycerol fructose combined with vitamin B6 is beneficial to the postoperative recovery of patients with cerebral aneurysm (CA). A total of 134 patients receiving embolization of CA in the Central Hospital of Wuhan between February, 2013 and June, 2015 and were divided into observation and control groups according to the random number table method, with 67 cases in each group. The control was given vitamin B6 routine treatment, while the observation group received glycerol fructose on the basis of treatment in the control group. The incidence rate of postoperative complications after treatment, Glasgow coma scale (GCS) score, Barthel index score, and neurological fatigue index (NFI) score were compared between the two groups. After treatment, the GCS, Barthel index and NFI scores of patients in the observation were better than those in the control group (p<0.05), and the Barthel index score in the observation group was significantly higher than that in the control group (p<0.01). The mean flow velocity of middle cerebral artery (MCA) in the observation group after treatment was significantly different from that in the control group (p<0.05). As for complications, the incidence rates of postoperative cerebral vasospasm (1.49%), cerebral ischemia (1.49%), hematoma at puncture site (2.98%) and aneurysm rupture and hemorrhage (4.47%) in the observation group were lower than those of cerebral vasospasm (8.95%), cerebral ischemia (7.46%), hematoma at puncture site (8.95%) and aneurysm rupture and hemorrhage (10.44%) in the control group, and the differences were statistically significant (p<0.05). In conclusion, glycerol fructose combined with vitamin B6 can reduce the incidence rate of postoperative complications and improve patients' self-care ability and quality of life. Therefore, it is beneficial to postoperative recovery and it is worthy of clinical application.

View Figures

View References

1	Chalouhi N, Hoh BL and Hasan D: Review of cerebral aneurysm formation, growth, and rupture. Stroke. 44:3613–3622. 2013. View Article : Google Scholar : PubMed/NCBI
2	Starke RM, Chalouhi N, Ding D, Raper DM, Mckisic MS, Owens GK, Hasan DM, Medel R and Dumont AS: Vascular smooth muscle cells in cerebral aneurysm pathogenesis. Transl Stroke Res. 5:338–346. 2014. View Article : Google Scholar : PubMed/NCBI
3	Skodvin TØ, Johnsen LH, Gjertsen Ø, Isaksen JG and Sorteberg A: Cerebral aneurysm morphology before and after rupture: Nationwide case series of 29 aneurysms. Stroke. 48:880–886. 2017. View Article : Google Scholar : PubMed/NCBI
4	Aldakkan A, Mansouri A, Jaja BN, Alotaibi NM and Macdonald RL: Subarachnoid Hemorrhage International Trialists Collaborators: Predictors of delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage with asymptomatic angiographic vasospasm on admission. World World Neurosurg. 97:199–204. 2017. View Article : Google Scholar : PubMed/NCBI
5	Chen M: A checklist for cerebral aneurysm embolization complications. J Neurointerv Surg. 5:20–27. 2013. View Article : Google Scholar : PubMed/NCBI
6	Brinjikji W, Lanzino G, Cloft HJ, Siddiqui AH, Boccardi E, Cekirge S, Fiorella D, Hanel R, Jabbour P, Levy E, et al: Risk factors for ischemic complications following pipeline embolization device treatment of intracranial aneurysms: Results from the IntrePED study. AJNR Am J Neuroradiol. 37:1673–1678. 2016. View Article : Google Scholar : PubMed/NCBI
7	Almandoz Delgado JE, Crandall BM, Scholz JM, Fease JL, Anderson RE, Kadkhodayan Y and Tubman DE: Last-recorded P2Y12 reaction units value is strongly associated with thromboembolic and hemorrhagic complications occurring up to 6 months after treatment in patients with cerebral aneurysms treated with the pipeline embolization device. AJNR Am J Neuroradiol. 35:128–135. 2014. View Article : Google Scholar : PubMed/NCBI
8	Pantophlet AJ, Gilbert MS, van den Borne JJGC, Gerrits WJ, Roelofsen H, Priebe MG and Vonk RJ: Lactose in milk replacer can partly be replaced by glucose, fructose, or glycerol without affecting insulin sensitivity in veal calves. J Dairy Sci. 99:3072–3080. 2016. View Article : Google Scholar : PubMed/NCBI
9	Masoumi SZ, Ataollahi M and Oshvandi K: Effect of combined use of calcium and vitamin B6 on premenstrual syndrome symptoms: A Randomized Clinical Trial. J Caring Sci. 5:67–73. 2016. View Article : Google Scholar : PubMed/NCBI
10	Singh N, Hopkins SJ, Hulme S, Galea JP, Hoadley M, Vail A, Hutchinson PJ, Grainger S, Rothwell NJ, King AT, et al: Critical role of TNF-α in cerebral aneurysm formation and progression to rupture. J Neuroinflammation. 11:2014.doi: 10.1186/1742-2094-11-1.
11	Yoshimura Y, Murakami Y, Saitoh M, Yokoi T, Aoki T, Miura K, Ueshima H and Nozaki K: SSS Research Group: Statin use and risk of cerebral aneurysm rupture: A hospital-based case-control study in Japan. J Stroke Cerebrovasc Dis. 23:343–348. 2014. View Article : Google Scholar : PubMed/NCBI
12	Macdonald I, Keyser A and Pacy D: Some effects, in man, of varying the load of glucose, sucrose, fructose, or sorbitol on various metabolites in blood. Am J Clin Nutr. 31:1305–1311. 1978. View Article : Google Scholar : PubMed/NCBI
13	Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, et al: Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. J Clin Invest. 127:4059–4074. 2017. View Article : Google Scholar : PubMed/NCBI
14	Tsubokawa T, Katayama Y and Ishii S: Fructose-added glycerol (Glyceol) for therapy of elevated intracranial pressure: Analysis of the side effects of long-term administration in a multi-institutional trial. Neurol Res. 11:249–252. 1989. View Article : Google Scholar : PubMed/NCBI
15	Wisam D, Nathan M, Juliette R and Yves B: Role of vitamin B6 in idiopathic burning mouth syndrome: Some clinical observations. J Biol Buccale. 23:77–83. 2016.
16	Stouder CE, Warren KJ, Perdue OF, Stewart AL, Padgett CW, Amonette AJ and Saha A: Synthesis, characterization, computational study, and biological relevance of a family of isostructural, mononuclear Ln (Ln = Gd, Tb, Dy, Ho, Er) complexes containing pyridoxine, an essential ingredient of vitamin B6 enzyme. Inorg Chim Acta. 464:172–181. 2017. View Article : Google Scholar
17	Hofmann MA, Lalla E, Lu Y, Gleason MR, Wolf BM, Tanji N, Ferran LJ Jr, Kohl B, Rao V, Kisiel W, et al: Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest. 107:675–683. 2001. View Article : Google Scholar : PubMed/NCBI
18	Wu Y, Liu Y, Han Y, Cui B, Mi Q, Huang Y, Wang L, Jiang Q, Chen Q, Liu N, et al: Pyridoxine increases nitric oxide biosynthesis in human platelets. Int J Vitam Nutr Res. 79:95–103. 2009. View Article : Google Scholar : PubMed/NCBI
19	Gkaliagkousi E, Ritter J and Ferro A: Platelet-derived nitric oxide signaling and regulation. Circ Res. 101:654–662. 2007. View Article : Google Scholar : PubMed/NCBI
20	Rosenberg J, Ischebeck T and Commichau FM: Vitamin B6 metabolism in microbes and approaches for fermentative production. Biotechnol Adv. 35:31–40. 2017. View Article : Google Scholar : PubMed/NCBI