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Article

Maternal lipids, BMI and IL‑17/IL‑35 imbalance in concurrent gestational diabetes mellitus and preeclampsia

  • Authors:
    • Weiping Cao
    • Xinzhi Wang
    • Tingmei Chen
    • Wenlin Xu
    • Fan Feng
    • Songlan Zhao
    • Zuxian Wang
    • Yu Hu
    • Bing Xie
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics, Maternity and Child Health Hospital of Zhenjiang, Zhenjiang, Jiangsu 212001, P.R. China, Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu 210009, P.R. China, Central Laboratory of Medicine, Maternity and Child Health Hospital of Zhenjiang, Zhenjiang, Jiangsu 212001, P.R. China, Department of Obstetrics and Gynecology, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China, Department of Nursing, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China
  • Pages: 427-435
    |
    Published online on: May 10, 2018
       https://doi.org/10.3892/etm.2018.6144
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Abstract

The objective of the present study was to investigate the role of blood glucose, lipid metabolism, body mass index (BMI), C‑reactive protein (CRP) as well as an interleukin (IL)‑17/IL‑35 imbalance in the pathogenesis of concurrent gestational diabetes mellitus (GDM) and preeclampsia (PE) (DPE). The mRNA expression of forkhead box protein 3 (FoxP3), IL‑35 [including Epstein‑Barr virus‑induced gene 3 (EBI3) and P35 subunits] and IL‑17 in the peripheral blood mononuclear cells of patients with DPE (n=30), GDM (n=33), PE (n=33) and normal pregnancy (n=33) were determined by reverse transcription‑quantitative polymerase chain reaction. The serum levels of IL‑35, IL‑17 and CRP were analyzed using ELISA. Serum total cholesterol (TC), triglyceride (TG), high‑density lipoprotein (HDL) and fasting blood glucose (FBG) were also detected. The levels of low‑density lipoprotein (LDL) were calculated using the Friedewald formula. Body weight and height were determined in order to calculate the BMI. It was observed that the levels of FBG were markedly elevated in patients with GDM, PE and DPE. In addition, significantly higher serum TG, TC, LDL and very LDL were detected in patients with GDM, PE and DPE compared with those in subjects with normal pregnancies. By contrast, the concentration of HDL was lower in the patient groups. In addition, higher BMI values were identified in patients with GDM, PE and DPE. A decreased expression of FoxP3, P35 and EBI3 mRNA, and an elevated expression of IL‑17 in PBMCs was detected in patients with GDM, PE and DPE. In addition, higher serum levels of IL‑17 and CRP, as well as lower levels of IL‑35, were observed. Furthermore, in patients with DPE, positive correlations of diastolic blood pressure with IL‑17 levels, BMI and TG, as well as IL‑17 levels with BMI and proteinuria were identified. In conclusion, the present study indicated that abnormal maternal lipids, hyperglycemia, high BMI, high CRP and IL‑17/IL‑35 imbalance may have a role in the pathophysiology of DPE. Therefore, pregnant women and clinicians should be made aware that maternal hyperlipidaemia, hyperglycemia, high BMI, high CRP levels and IL‑17/IL‑35 imbalance may lead to DPE.
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Copy and paste a formatted citation
Spandidos Publications style
Cao W, Wang X, Chen T, Xu W, Feng F, Zhao S, Wang Z, Hu Y and Xie B: Maternal lipids, BMI and IL‑17/IL‑35 imbalance in concurrent gestational diabetes mellitus and preeclampsia. Exp Ther Med 16: 427-435, 2018.
APA
Cao, W., Wang, X., Chen, T., Xu, W., Feng, F., Zhao, S. ... Xie, B. (2018). Maternal lipids, BMI and IL‑17/IL‑35 imbalance in concurrent gestational diabetes mellitus and preeclampsia. Experimental and Therapeutic Medicine, 16, 427-435. https://doi.org/10.3892/etm.2018.6144
MLA
Cao, W., Wang, X., Chen, T., Xu, W., Feng, F., Zhao, S., Wang, Z., Hu, Y., Xie, B."Maternal lipids, BMI and IL‑17/IL‑35 imbalance in concurrent gestational diabetes mellitus and preeclampsia". Experimental and Therapeutic Medicine 16.1 (2018): 427-435.
Chicago
Cao, W., Wang, X., Chen, T., Xu, W., Feng, F., Zhao, S., Wang, Z., Hu, Y., Xie, B."Maternal lipids, BMI and IL‑17/IL‑35 imbalance in concurrent gestational diabetes mellitus and preeclampsia". Experimental and Therapeutic Medicine 16, no. 1 (2018): 427-435. https://doi.org/10.3892/etm.2018.6144
Copy and paste a formatted citation
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Spandidos Publications style
Cao W, Wang X, Chen T, Xu W, Feng F, Zhao S, Wang Z, Hu Y and Xie B: Maternal lipids, BMI and IL‑17/IL‑35 imbalance in concurrent gestational diabetes mellitus and preeclampsia. Exp Ther Med 16: 427-435, 2018.
APA
Cao, W., Wang, X., Chen, T., Xu, W., Feng, F., Zhao, S. ... Xie, B. (2018). Maternal lipids, BMI and IL‑17/IL‑35 imbalance in concurrent gestational diabetes mellitus and preeclampsia. Experimental and Therapeutic Medicine, 16, 427-435. https://doi.org/10.3892/etm.2018.6144
MLA
Cao, W., Wang, X., Chen, T., Xu, W., Feng, F., Zhao, S., Wang, Z., Hu, Y., Xie, B."Maternal lipids, BMI and IL‑17/IL‑35 imbalance in concurrent gestational diabetes mellitus and preeclampsia". Experimental and Therapeutic Medicine 16.1 (2018): 427-435.
Chicago
Cao, W., Wang, X., Chen, T., Xu, W., Feng, F., Zhao, S., Wang, Z., Hu, Y., Xie, B."Maternal lipids, BMI and IL‑17/IL‑35 imbalance in concurrent gestational diabetes mellitus and preeclampsia". Experimental and Therapeutic Medicine 16, no. 1 (2018): 427-435. https://doi.org/10.3892/etm.2018.6144
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