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Nicotine reduces effectiveness of doxorubicin chemotherapy and promotes CD44+CD24‑ cancer stem cells in MCF‑7 cell populations

  • Authors:
    • Leyla Türker Şener
    • Celal Güven
    • Aziz Şener
    • Suzan Adin Çinar
    • Seyhun Solakoğlu
    • Işil Albeniz
  • View Affiliations / Copyright

    Affiliations: Department of Biophysics, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey, Department of Biophysics, Faculty of Medicine, Niğde Ömer Halisdemir, 02040 Nigde, Turkey, Department of General Surgery, Kanuni Sultan Suleyman Training and Research Hospital, 34306 Istanbul, Turkey, Department of Immunology, Institute of Experimental Medicine, Istanbul University, 34093 Istanbul, Turkey, Department of Histology and Embryology, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey
    Copyright: © Türker Şener et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 21-28
    |
    Published online on: May 10, 2018
       https://doi.org/10.3892/etm.2018.6149
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Abstract

Breast cancer is the most common type of cancer in females and the second most common cause of cancer mortality after lung cancer. Cancer stem cells represent a novel approach to target cancer and reduce cancer recurrence and metastasis. Many patients with breast cancer continue to smoke after receiving their diagnosis. Nicotine is a key factor in tobacco addiction and also changes some cellular functions, such as activation of mitogenic pathways, angiogenesis and cell proliferation. In the present study, the impact of nicotine was assessed in a population of MCF‑7 human breast cancer cells. Cluster of differentiation (CD)44+CD24‑ cancer stem cell population of MCF‑7 cells were evaluated using flow cytometry and scanning electron microscopy. Chemoresistance effects of nicotine were demonstrated in these cells. These findings demonstrated harmful effects of nicotine following metastasis of cancer, owing to the chemoresistance produced through uninterrupted smoking, which may impact the effectiveness of treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Türker Şener L , Güven C, Şener A, Adin Çinar S , Solakoğlu S and Albeniz I: Nicotine reduces effectiveness of doxorubicin chemotherapy and promotes CD44+CD24‑ cancer stem cells in MCF‑7 cell populations. Exp Ther Med 16: 21-28, 2018.
APA
Türker Şener, L. ., Güven, C., Şener, A., Adin Çinar, S. ., Solakoğlu, S., & Albeniz, I. (2018). Nicotine reduces effectiveness of doxorubicin chemotherapy and promotes CD44+CD24‑ cancer stem cells in MCF‑7 cell populations. Experimental and Therapeutic Medicine, 16, 21-28. https://doi.org/10.3892/etm.2018.6149
MLA
Türker Şener, L. ., Güven, C., Şener, A., Adin Çinar, S. ., Solakoğlu, S., Albeniz, I."Nicotine reduces effectiveness of doxorubicin chemotherapy and promotes CD44+CD24‑ cancer stem cells in MCF‑7 cell populations". Experimental and Therapeutic Medicine 16.1 (2018): 21-28.
Chicago
Türker Şener, L. ., Güven, C., Şener, A., Adin Çinar, S. ., Solakoğlu, S., Albeniz, I."Nicotine reduces effectiveness of doxorubicin chemotherapy and promotes CD44+CD24‑ cancer stem cells in MCF‑7 cell populations". Experimental and Therapeutic Medicine 16, no. 1 (2018): 21-28. https://doi.org/10.3892/etm.2018.6149
Copy and paste a formatted citation
x
Spandidos Publications style
Türker Şener L , Güven C, Şener A, Adin Çinar S , Solakoğlu S and Albeniz I: Nicotine reduces effectiveness of doxorubicin chemotherapy and promotes CD44+CD24‑ cancer stem cells in MCF‑7 cell populations. Exp Ther Med 16: 21-28, 2018.
APA
Türker Şener, L. ., Güven, C., Şener, A., Adin Çinar, S. ., Solakoğlu, S., & Albeniz, I. (2018). Nicotine reduces effectiveness of doxorubicin chemotherapy and promotes CD44+CD24‑ cancer stem cells in MCF‑7 cell populations. Experimental and Therapeutic Medicine, 16, 21-28. https://doi.org/10.3892/etm.2018.6149
MLA
Türker Şener, L. ., Güven, C., Şener, A., Adin Çinar, S. ., Solakoğlu, S., Albeniz, I."Nicotine reduces effectiveness of doxorubicin chemotherapy and promotes CD44+CD24‑ cancer stem cells in MCF‑7 cell populations". Experimental and Therapeutic Medicine 16.1 (2018): 21-28.
Chicago
Türker Şener, L. ., Güven, C., Şener, A., Adin Çinar, S. ., Solakoğlu, S., Albeniz, I."Nicotine reduces effectiveness of doxorubicin chemotherapy and promotes CD44+CD24‑ cancer stem cells in MCF‑7 cell populations". Experimental and Therapeutic Medicine 16, no. 1 (2018): 21-28. https://doi.org/10.3892/etm.2018.6149
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