miR‑199b‑5p serves as a tumor suppressor in renal cell carcinoma

Corrigendum in: /10.3892/etm.2018.6333 Corrigendum in: /10.3892/etm.2024.12422

  • Authors:
    • Yulin Lai
    • Jing Quan
    • Canbin Lin
    • Hang Li
    • Jia Hu
    • Peijie Chen
    • Jinling Xu
    • Xin Guan
    • Weijie Xu
    • Yongqing Lai
    • Liangchao Ni
  • View Affiliations

  • Published online on: May 10, 2018     https://doi.org/10.3892/etm.2018.6151
  • Pages: 436-444
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Abstract

MicroRNA (miR)‑199b‑5p has been reported to have a critical role in various types of malignancy. However, the exact function miR‑199b‑5p in renal cancer remains to be fully elucidated. The present study aimed to detect the expression levels of miR‑199b‑5p in renal cell carcinoma (RCC) tissues and RCC cell lines, and investigated the effect of miR‑199b‑5p in vitro with Cell Counting Kit‑8, MTT, scratch wound, Transwell and flow cytometric assays. The results demonstrated that the expression levels of miR‑199b‑5p were significantly downregulated in RCC tissues and cell lines compared with those in paired adjacent normal renal tissues and a reference cell line, respectively. Downregulation of miR‑199b‑5p by transfection with a synthetic inhibitor promoted cellular proliferation and migration, while reducing the apoptotic rate, indicating that miR‑199b‑5p may serve as a tumor suppressor in RCC. Further study is required to identify target genes of miR‑199b‑5p to elucidate the mechanisms underlying the role of miR‑199b‑5p in the occurrence and development of RCC.
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July-2018
Volume 16 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Lai Y, Quan J, Lin C, Li H, Hu J, Chen P, Xu J, Guan X, Xu W, Lai Y, Lai Y, et al: miR‑199b‑5p serves as a tumor suppressor in renal cell carcinoma Corrigendum in /10.3892/etm.2018.6333 Corrigendum in /10.3892/etm.2024.12422. Exp Ther Med 16: 436-444, 2018
APA
Lai, Y., Quan, J., Lin, C., Li, H., Hu, J., Chen, P. ... Ni, L. (2018). miR‑199b‑5p serves as a tumor suppressor in renal cell carcinoma Corrigendum in /10.3892/etm.2018.6333 Corrigendum in /10.3892/etm.2024.12422. Experimental and Therapeutic Medicine, 16, 436-444. https://doi.org/10.3892/etm.2018.6151
MLA
Lai, Y., Quan, J., Lin, C., Li, H., Hu, J., Chen, P., Xu, J., Guan, X., Xu, W., Lai, Y., Ni, L."miR‑199b‑5p serves as a tumor suppressor in renal cell carcinoma Corrigendum in /10.3892/etm.2018.6333 Corrigendum in /10.3892/etm.2024.12422". Experimental and Therapeutic Medicine 16.1 (2018): 436-444.
Chicago
Lai, Y., Quan, J., Lin, C., Li, H., Hu, J., Chen, P., Xu, J., Guan, X., Xu, W., Lai, Y., Ni, L."miR‑199b‑5p serves as a tumor suppressor in renal cell carcinoma Corrigendum in /10.3892/etm.2018.6333 Corrigendum in /10.3892/etm.2024.12422". Experimental and Therapeutic Medicine 16, no. 1 (2018): 436-444. https://doi.org/10.3892/etm.2018.6151