Effects of Kangfuxin solution on IL‑1β, IL‑6, IL‑17 and TNF‑α in gingival crevicular fluid in patients with fixed orthodontic gingivitis

Liu,Yuting; Mu,Fengping; Liu,Lijuan; Shan,Chune

doi:10.3892/etm.2018.6171

July-2018 Volume 16 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

July-2018 Volume 16 Issue 1

Full Size Image

Article Open Access

Effects of Kangfuxin solution on IL‑1β, IL‑6, IL‑17 and TNF‑α in gingival crevicular fluid in patients with fixed orthodontic gingivitis

Authors:
- Yuting Liu
- Fengping Mu
- Lijuan Liu
- Chune Shan
View Affiliations / Copyright

Affiliations: Department of Dentistry, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Department of Oral and Maxillofacial Surgery, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Clinical Skill Training Center, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China

Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 300-304
|
Published online on: May 16, 2018

https://doi.org/10.3892/etm.2018.6171
Expand metrics +

Abstract

Changes of interleukin (IL)‑1β, IL‑6, IL‑17 and tumor necrosis factor‑α (TNF‑α) in gingival crevicular fluid in patients with fixed orthodontic gingivitis after treatment with Kangfuxin solution were analyzed to explore the clinical effect of Kangfuxin solution in patients with orthodontic gingivitis. A total of 78 patients diagnosed with fixed orthodontic gingivitis in Weifang People's Hospital from January 2015 to March 2017 were selected. Thirty‑nine patients were treated with gingival cleansing as control group, and the other 39 patients were treated with gingival cleansing plus spraying and sublingual administration with Kangfuxin solution as treatment group. The general data of patients were collected, and the changes of IL‑1β, IL‑6, IL‑17 and TNF‑α in gingival crevicular fluid were measured, the bleeding index (BI), probing depth (PD), swelling and pain grades were recorded, and the clinical curative effects were compared between the two groups. The curative effect in treatment group was better than that in control group (p<0.05). After treatment, gingival BI and PD in both groups were lower than those before treatment. The curative effect in treatment group was better than that in control group (p<0.05). The levels of gingival pain and swelling after treatment in treatment group were mainly in grade I. The levels of gingival pain and swelling after treatment in control group were mainly in grade Ⅱ and Ⅲ (p<0.05). After treatment, the effective rate of control group was 76.92% and that of treatment group was 97.44% (p<0.05). It was found that the levels of IL‑6 and TNF‑α in gingival crevicular fluid were positively correlated with PD. The use of Kangfuxin solution in the treatment of patients with orthodontic gingivitis can effectively reduce the levels of IL‑1β, IL‑6, IL‑17 and TNF‑α in gingival crevicular fluid, and improve the periodontal conditions and the effective rate of treatment.

View Figures

View References

1	Lakschevitz F, Aboodi G, Tenenbaum H and Glogauer M: Diabetes and periodontal diseases: Interplay and links. Curr Diabetes Rev. 7:433–439. 2011. View Article : Google Scholar : PubMed/NCBI
2	Duarte PM, Bezerra JP, Miranda TS, Feres M, Chambrone L and Shaddox LM: Local levels of inflammatory mediators in uncontrolled type 2 diabetic subjects with chronic periodontitis. J Clin Periodontol. 41:11–18. 2014. View Article : Google Scholar : PubMed/NCBI
3	Kossack C and Jost-Brinkmann PG: Plaque and gingivitis reduction in patients undergoing orthodontic treatment with fixed appliances-comparison of toothbrushes and interdental cleaning aids. A 6-month clinical single-blind trial. J Orofac Orthop. 66:20–38. 2005. View Article : Google Scholar : PubMed/NCBI
4	Sánchez GA, Miozza VA, Delgado A and Busch L: Salivary IL-1β and PGE2 as biomarkers of periodontal status, before and after periodontal treatment. J Clin Periodontol. 40:1112–1117. 2013. View Article : Google Scholar : PubMed/NCBI
5	Persson GR and Persson RE: Cardiovascular disease and periodontitis: An update on the associations and risk. J Clin Periodontol. 35 Suppl:362–379. 2008. View Article : Google Scholar : PubMed/NCBI
6	Luke R, Khan SN, Iqbal PS, Soman RR, Chakkarayan J and Krishnan V: Estimation of specific salivary enzymatic biomarkers in individuals with gingivitis and chronic periodontitis: A clinical and biochemical study. J Int Oral Health. 7:54–57. 2015.PubMed/NCBI
7	Abhishek KN, Supreetha S, Sam G, Khan SN, Chaithanya KH and Abdul N: Effect of neem containing toothpaste on plaque and gingivitis - a randomized double blind clinical trial. J Contemp Dent Pract. 16:880–883. 2015. View Article : Google Scholar : PubMed/NCBI
8	Kirschneck C, Christl JJ, Reicheneder C and Proff P: Efficacy of fluoride varnish for preventing white spot lesions and gingivitis during orthodontic treatment with fixed appliances - a prospective randomized controlled trial. Clin Oral Investig. 20:2371–2378. 2016. View Article : Google Scholar : PubMed/NCBI
9	Sedighrahimabadi M, Shams M, Fani M and Chijan MR: Gingivitis from the viewpoint of traditional Persian medicine. Iran J Med Sci. 41:S352016.
10	Gopinath VK, Rahman B and Awad MA: Assessment of gingival health among school children in Sharjah, United Arab Emirates. Eur J Dent. 9:36–40. 2015. View Article : Google Scholar : PubMed/NCBI
11	Santos MT, Ferreira MC, Guaré RO, Diniz MB, Rösing CK, Rodrigues JA and Duarte DA: Gingivitis and salivary osmolality in children with cerebral palsy. Int J Paediatr Dent. 26:463–470. 2016. View Article : Google Scholar : PubMed/NCBI
12	Azodo CC and Agbor AM: Gingival health and oral hygiene practices of school children in the North West region of Cameroon. BMC Res Notes. 8:3852015. View Article : Google Scholar : PubMed/NCBI
13	Jovito VC, Freires IA, Ferreira DA, Paulo MQ and Castro RD: Eugenia uniflora dentifrice for treating gingivitis in children: Antibacterial assay and randomized clinical trial. Braz Dent J. 27:387–392. 2016. View Article : Google Scholar : PubMed/NCBI
14	Ravikumar R, Manohar R, Latha SM and Scott JX: Gingival hypertrophy in a child: Expect the unexpected. Indian J Dent. 7:112–114. 2016. View Article : Google Scholar : PubMed/NCBI
15	Detert J, Pischon N, Burmester GR and Buttgereit F: The association between rheumatoid arthritis and periodontal disease. Arthritis Res Ther. 12:218–225. 2010. View Article : Google Scholar : PubMed/NCBI
16	Gurav A and Jadhav V: Periodontitis and risk of diabetes mellitus. J Diabetes. 3:21–28. 2011. View Article : Google Scholar : PubMed/NCBI
17	Covani U, Marconcini S, Derchi G, Barone A and Giacomelli L: Relationship between human periodontitis and type 2 diabetes at a genomic level: A data-mining study. J Periodontol. 80:1265–1273. 2009. View Article : Google Scholar : PubMed/NCBI
18	Gamonal J, Acevedo A, Bascones A, Jorge O and Silva A: Levels of interleukin-1 beta, −8, and −10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment. J Periodontol. 71:1535–1545. 2000. View Article : Google Scholar : PubMed/NCBI
19	Acharya AB, Thakur S and Muddapur MV: Evaluation of serum interleukin-10 levels as a predictor of glycemic alteration in chronic periodontitis and type 2 diabetes mellitus. J Indian Soc Periodontol. 19:388–392. 2015. View Article : Google Scholar : PubMed/NCBI
20	Pradeep AR, Martande SS, Singh SP, Suke DK, Raju AP and Naik SB: Correlation of human S100A12 (EN-RAGE) and high-sensitivity C-reactive protein as gingival crevicular fluid and serum markers of inflammation in chronic periodontitis and type 2 diabetes. Inflamm Res. 63:317–323. 2014. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effects of Kangfuxin solution on IL‑1β, IL‑6, IL‑17 and TNF‑α in gingival crevicular fluid in patients with fixed orthodontic gingivitis

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles