Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effect of interleukin‑31 on septic shock through regulating inflammasomes and interleukin‑1β

  • Authors:
    • Xuyun Gu
    • Chen Wei
    • Xishan Zhu
    • Feiping Lu
    • Bo Sheng
    • Xuefeng Zang
  • View Affiliations / Copyright

    Affiliations: Department of Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China, Department of Cancer Chemotherapy, Peking University First Hospital, Beijing 100038, P.R. China
    Copyright: © Gu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 171-177
    |
    Published online on: May 17, 2018
       https://doi.org/10.3892/etm.2018.6181
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Sepsis with severe systemic inflammation remains a great challenge for the intensive care unit in clinics. Although biomarkers have been identified to diagnose, monitor and predict these syndromes, novel therapeutic approaches are required for the amelioration of symptoms of sepsis and septic shock. The present study demonstrated that interleukin (IL)‑31 was able reduce the mortality rate of lipopolysaccharide (LPS)‑induced sepsis with the reduction of inflammatory cytokines in the sera. IL‑31 also inhibited IL‑1β production in the peritoneal lavage fluid in LPS‑induced or cecal ligation and puncture‑induced sepsis. The in vitro mechanism responsible for IL‑31 regulation on peritoneal IL‑1β activation following LPS challenge was explored. It was demonstrated that IL‑1β secretion was suppressed by IL‑31 treatment from LPS‑challenged peritoneal macrophages following adenosine triphosphate stimulation, which is an activator of NLR family, pyrin domain‑containing 3 (NLRP3). Furthermore, IL‑31 inhibited the expression of NLRP3 at the transcriptional level. In human THP‑1 cells, anti‑IL‑31/anti‑IL‑31 receptor (R) neutralizing antibody enhanced NLRP3 expression as well as IL‑1β activation, suggesting a role of the IL‑31‑IL‑31R‑NLRP3‑IL‑1β signaling axis in the physiological status of sepsis. On the other hand, IL‑31 displayed a negative effect on the NLRP1 inflammasome, but not on NLRP3 on the LPS‑primed human peripheral blood monocytes, resulting in reduction of the inflammatory cytokine, tumor necrosis factor (TNF)‑α, in the supernatant. Taken together, the present data implied that T helper 2‑type cytokine, IL‑31, may be a promising therapeutic option for treatment of sepsis and septic shock in clinics.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Kumar A, Ellis P, Arabi Y, Roberts D, Light B, Parrillo JE, Dodek P, Wood G, Kumar A, Simon D, et al: Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest. 136:1237–1248. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Schuetz P, Maurer P, Punjabi V, Desai A, Amin DN and Gluck E: Procalcitonin decrease over 72 hours in US critical care units predicts fatal outcome in sepsis patients. Crit Care. 17:R1152013. View Article : Google Scholar : PubMed/NCBI

3 

Standage SW and Wong HR: Biomarkers for pediatric sepsis and septic shock. Expert Rev Anti Infect Ther. 9:71–79. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, et al: Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 36:296–327. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Alqahtani MF, Smith CM, Weiss SL, Dawson S, Ranaivo Ralay H and Wainwright MS: Evaluation of new diagnostic biomarkers in pediatric sepsis: Matrix Metalloproteinase-9, tissue inhibitor of metalloproteinase-1, mid-regional pro-atrial natriuretic peptide, and adipocyte fatty-acid binding protein. PLoS One. 11:e01536452016. View Article : Google Scholar : PubMed/NCBI

6 

Gucyetmez B and Atalan HK: C-reactive protein and hemogram parameters for the non-sepsis systemic inflammatory response syndrome and sepsis: What do they mean? PLoS One. 11:e01486992016. View Article : Google Scholar : PubMed/NCBI

7 

Gearing DP, Comeau MR, Friend DJ, Gimpel SD, Thut CJ, McGourty J, Brasher KK, King JA, Gillis S, Mosley B, et al: The IL-6 signal transducer, gp130: An oncostatin M receptor and affinity converter for the LIF receptor. Science. 255:1434–1437. 1992. View Article : Google Scholar : PubMed/NCBI

8 

Hänel KH, Pfaff CM, Cornelissen C, Amann PM, Marquardt Y, Czaja K, Kim A, Lüscher B and Baron JM: Control of the physical and antimicrobial skin barrier by an IL-31-IL-1 signaling network. J Immunol. 196:3233–3244. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Kasutani K, Fujii E, Ohyama S, Adachi H, Hasegawa M, Kitamura H and Yamashita N: Anti-IL-31 receptor antibody is shown to be a potential therapeutic option for treating itch and dermatitis in mice. Br J Pharmacol. 171:5049–5058. 2014.PubMed/NCBI

10 

Hwang JS, Kim GC, Park E, Kim JE, Chae CS, Hwang W, Lee C, Hwang SM, Wang HS, Jun CD, et al: NFAT1 and JunB cooperatively regulate IL-31 gene expression in CD4+ T cells in health and disease. J Immunol. 194:1963–1974. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Kasraie S, Niebuhr M and Werfel T: Interleukin (IL)-31 activates signal transducer and activator of transcription (STAT)-1, STAT-5 and extracellular signal-regulated kinase 1/2 and down-regulates IL-12p40 production in activated human macrophages. Allergy. 68:739–747. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Kunsleben N, Rüdrich U, Gehring M, Novak N, Kapp A and Raap U: IL-31 induces chemotaxis, calcium mobilization, release of reactive oxygen species, and CCL26 in eosinophils, which are capable to release IL-31. J Invest Dermatol. 135:1908–1911. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Perrigoue JG, Li J, Zaph C, Goldschmidt M, Scott P, de Sauvage FJ, Pearce EJ, Ghilardi N and Artis D: IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung. J Exp Med. 204:481–487. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Perrigoue JG, Zaph C, Guild K, Du Y and Artis D: IL-31-IL-31R interactions limit the magnitude of Th2 cytokine-dependent immunity and inflammation following intestinal helminth infection. J Immunol. 182:6088–6094. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Schmidt RL and Lenz LL: Distinct licensing of IL-18 and IL-1β secretion in response to NLRP3 inflammasome activation. PLoS One. 7:e451862012. View Article : Google Scholar : PubMed/NCBI

16 

Brydges SD, Broderick L, McGeough MD, Pena CA, Mueller JL and Hoffman HM: Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies. J Clin Invest. 123:4695–4705. 2013. View Article : Google Scholar : PubMed/NCBI

17 

van de Veerdonk FL, Netea MG, Dinarello CA and Joosten LA: Inflammasome activation and IL-1β and IL-18 processing during infection. Trends Immunol. 32:110–116. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Ketelut-Carneiro N, Silva GK, Rocha FA, Milanezi CM, Cavalcanti-Neto FF, Zamboni DS and Silva JS: IL-18 triggered by the Nlrp3 inflammasome induces host innate resistance in a pulmonary model of fungal infection. J Immunol. 194:4507–4517. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Rittirsch D, Huber-Lang MS, Flierl MA and Ward PA: Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc. 4:31–36. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Ding AH, Nathan CF and Stuehr DJ: Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol. 141:2407–2412. 1988.PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Caserta S, Kern F, Cohen J, Drage S, Newbury SF and Llewelyn MJ: Circulating plasma microRNAs can differentiate human sepsis and systemic inflammatory response syndrome (SIRS). Sci Rep. 6:280062016. View Article : Google Scholar : PubMed/NCBI

23 

Müller B, Becker KL, Schächinger H, Rickenbacher PR, Huber PR, Zimmerli W and Ritz R: Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit. Crit Care Med. 28:977–983. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Bozza FA, Salluh JI, Japiassu AM, Soares M, Assis EF, Gomes RN, Bozza MT, Castro-Faria-Neto HC and Bozza PT: Cytokine profiles as markers of disease severity in sepsis: A multiplex analysis. Crit Care. 11:R492007. View Article : Google Scholar : PubMed/NCBI

25 

Wong HR, Cvijanovich N, Wheeler DS, Bigham MT, Monaco M, Odoms K, Macias WL and Williams MD: Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock. Am J Respir Crit Care Med. 178:276–282. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Wei XQ, Leung BP, Niedbala W, Piedrafita D, Feng GJ, Sweet M, Dobbie L, Smith AJ and Liew FY: Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice. J Immunol. 163:2821–2828. 1999.PubMed/NCBI

27 

Klein C, Wüstefeld T, Assmus U, Roskams T, Rose-John S, Müller M, Manns MP, Ernst M and Trautwein C: The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury. J Clin Invest. 115:860–869. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Lin MW, Lee DD, Liu TT, Lin YF, Chen SY, Huang CC, Weng HY, Liu YF, Tanaka A, Arita K, et al: Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. Eur J Hum Genet. 18:26–32. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Edukulla R, Singh B, Jegga AG, Sontake V, Dillon SR and Madala SK: Th2 Cytokines augment IL-31/IL-31RA interactions via STAT6-dependent IL-31RA expression. J Biol Chem. 290:13510–13520. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Lei Z, Liu G, Huang Q, Lv M, Zu R, Zhang GM, Feng ZH and Huang B: SCF and IL-31 rather than IL-17 and BAFF are potential indicators in patients with allergic asthma. Allergy. 63:327–332. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gu X, Wei C, Zhu X, Lu F, Sheng B and Zang X: Effect of interleukin‑31 on septic shock through regulating inflammasomes and interleukin‑1β. Exp Ther Med 16: 171-177, 2018.
APA
Gu, X., Wei, C., Zhu, X., Lu, F., Sheng, B., & Zang, X. (2018). Effect of interleukin‑31 on septic shock through regulating inflammasomes and interleukin‑1β. Experimental and Therapeutic Medicine, 16, 171-177. https://doi.org/10.3892/etm.2018.6181
MLA
Gu, X., Wei, C., Zhu, X., Lu, F., Sheng, B., Zang, X."Effect of interleukin‑31 on septic shock through regulating inflammasomes and interleukin‑1β". Experimental and Therapeutic Medicine 16.1 (2018): 171-177.
Chicago
Gu, X., Wei, C., Zhu, X., Lu, F., Sheng, B., Zang, X."Effect of interleukin‑31 on septic shock through regulating inflammasomes and interleukin‑1β". Experimental and Therapeutic Medicine 16, no. 1 (2018): 171-177. https://doi.org/10.3892/etm.2018.6181
Copy and paste a formatted citation
x
Spandidos Publications style
Gu X, Wei C, Zhu X, Lu F, Sheng B and Zang X: Effect of interleukin‑31 on septic shock through regulating inflammasomes and interleukin‑1β. Exp Ther Med 16: 171-177, 2018.
APA
Gu, X., Wei, C., Zhu, X., Lu, F., Sheng, B., & Zang, X. (2018). Effect of interleukin‑31 on septic shock through regulating inflammasomes and interleukin‑1β. Experimental and Therapeutic Medicine, 16, 171-177. https://doi.org/10.3892/etm.2018.6181
MLA
Gu, X., Wei, C., Zhu, X., Lu, F., Sheng, B., Zang, X."Effect of interleukin‑31 on septic shock through regulating inflammasomes and interleukin‑1β". Experimental and Therapeutic Medicine 16.1 (2018): 171-177.
Chicago
Gu, X., Wei, C., Zhu, X., Lu, F., Sheng, B., Zang, X."Effect of interleukin‑31 on septic shock through regulating inflammasomes and interleukin‑1β". Experimental and Therapeutic Medicine 16, no. 1 (2018): 171-177. https://doi.org/10.3892/etm.2018.6181
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team