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Article

Effects of hyperglycaemia and elevated glycosylated haemoglobin on contrast‑induced nephropathy after coronary angiography

  • Authors:
    • Yu‑Han Qin
    • Gao‑Liang Yan
    • Chang‑Le Ma
    • Cheng‑Chun Tang
    • Gen‑Shan Ma
  • View Affiliations / Copyright

    Affiliations: Medical Department of Southeast University, Nanjing, Jiangsu 210009, P.R. China, Department of Cardiology, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu 210009, P.R. China
  • Pages: 377-383
    |
    Published online on: May 18, 2018
       https://doi.org/10.3892/etm.2018.6183
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Abstract

In patients undergoing percutaneous coronary intervention after acute myocardial infarction, hyperglycaemia on admission is associated with an increased risk of contrast‑induced nephropathy (CIN). However, the effects of hyperglycaemia and elevated glycosylated haemoglobin (HbA1c) on CIN have remained to be fully elucidated. Therefore, a prospective cohort study was performed, comprising 258 patients who underwent coronary angiography between May 2017 and November 2017 at Zhongda Hospital affiliated with Southeast University (Nanjing, China). According to the diagnostic criteria for CIN (increase of serum creatinine by >44.2 µmol/l or by 25% within 48‑72 h of using contrast agent), the patients were divided into two groups: CIN (45 cases) and non‑CIN (213 cases). For all patients, the baseline data, medical history, laboratory parameters, medication history and intraoperative situation were recorded and assessed using single‑factor analysis and multiple logistic regression analysis to analyse the risk factors of CIN. The incidence of CIN in the hyperglycaemia group (blood glucose on admission, >11.1 mmol/l) was 25%, compared with 13.8% in the non‑hyperglycaemia group (P=0.026). Furthermore, the incidence of CIN in the elevated HbA1c group (HbA1c on admission, upper limit of normal) was 26.1%, compared with 14.3% in the group without elevated HbA1c (P=0.027). Hyperglycaemia was present on hospital admission in 84 of 258 patients (32.6%). The percentage of patients with elevated HbA1c was 26.7%. Age, estimated glomerular filtration rate, pre‑operative blood cholesterol, hyperglycaemia on admission and elevated HbA1c were all identified to be associated with CIN. According to the multivariate logistic regression analysis, hyperglycaemia was an independent predictor of CIN (odds ratio, 2.815; 95% confidence interval, 1.042‑4.581; P=0.029). In the acute coronary syndrome (ACS) and diabetes subgroups, hyperglycaemia was significantly associated with CIN. In the ACS subgroup, the incidence of CIN was 38.1%. It was indicated that hyperglycaemia is an independent risk factor for CIN, particularly in patients with ACS or diabetes. Trial registration no. ChiCTR‑OOC‑17011466.
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1 

James MT, Samuel SM, Manning MA, Tonelli M, Ghali WA, Faris P, Knudtson ML, Pannu N and Hemmelgarn BR: Contrast-induced acute kidney injury and risk of adverse clinical outcomes after coronary angiography: A systematic review and meta-analysis. Circ Cardiovasc Interv. 6:37–43. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Goyal A, Mehta SR, Gerstein HC, Díaz R, Afzal R, Xavier D, Zhu J, Pais P, Lisheng L, Kazmi KA, et al: Glucose levels compared with diabetes history in the risk assessment of patients with acute myocardial infarction. Am Heart J. 157:763–770. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Marenzi G, De Metrio M, Rubino M, Lauri G, Cavallero A, Assanelli E, Grazi M, Moltrasio M, Marana I, Campodonico J, et al: Acute hyperglycemia and contrast-induced nephropathy in primary percutaneous coronary intervention. Am Heart J. 160:1170–1177. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Stolker JM, McCullough PA, Rao S, Inzucchi SE, Spertus JA, Maddox TM, Masoudi FA, Xiao L and Kosiborod M: Pre-procedural glucose levels and the risk for contrast-induced acute kidney injury in patients undergoing coronary angiography. J Am Coll Cardiol. 55:1433–1440. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Perkan A, Cinquetti M, Giannini F, Santangelo S, Pirozzi F, Barbati G, Vitrella G, Rakar S, Salvi A and Sinagra G: Admission hyperglycemia and contrast induced nephropathy. Eur Heart J. 34:555. 2013. View Article : Google Scholar

6 

Barbieri L, Verdoia M, Schaffer A, Cassetti E, Di Giovine G, Marino P, Suryapranata H and De Luca G: Pre-diabetes and the risk of contrast induced nephropathy in patients undergoing coronary angiography or percutaneous intervention. Diabetes Res Clin Pract. 106:458–464. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Dungan KM, Braithwaite SS and Preiser J-C: Stress hyperglycaemia. Lancet. 373:1798–1807. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF III, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, et al: A new equation to estimate glomerular filtration rate. Ann Intern Med. 150:604–612. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Katsiki N, Athyros VG, Karagiannis A and Mikhailidis DP: Contrast-induced nephropathy: An ‘All or None’ phenomenon? Angiology. 66:508–513. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Selvin E, Marinopoulos S, Berkenblit G, Rami T, Brancati FL, Powe NR and Golden SH: Meta-analysis: Glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Internal Med. 141:421–431. 2004. View Article : Google Scholar

11 

Balkau B, Shipley M, Jarrett RJ, Pyorala K, Pyörälä K, Pyörälä M, Forhan A and Eschwège E: High blood glucose concentration is a risk factor for mortality in middle-aged nondiabetic men. 20-year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study. Diabetes Care. 21:360–367. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Xu Y, Wang L, He J, Bi Y, Li M, Wang T, Wang L, Jiang Y, Dai M, Lu J, et al: Prevalence and control of diabetes in Chinese adults. JAMA. 310:948–959. 2013. View Article : Google Scholar : PubMed/NCBI

13 

McCullough PA, Wolyn R, Rocher LL, Levin RN and Oneill WW: Acute renal failure after coronary intervention: Incidence, risk factors, and relationship to mortality. Am J Med. 103:368–375. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Norhammar A, Tenerz Å, Nilsson G, Hamsten A, Efendíc S, Rydén L and Malmberg K: Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: A prospective study. Lancet. 359:2140–2144. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Naruse H, Ishii J, Hashimoto T, Kawai T, Hattori K, Okumura M, Motoyama S, Matsui S, Tanaka I, Izawa H, et al: Pre-procedural glucose levels and the risk for contrast-induced acute kidney injury in patients undergoing emergency coronary intervention. Circ J. 76:1848–1855. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Allison SP, Tomlin PJ and Chamberlain MJ: Some effects of anaesthesia and surgery on carbohydrate and fat metabolism. Br J Anaesth. 41:588–593. 1969. View Article : Google Scholar : PubMed/NCBI

17 

Shacham Y, Steinvil A and Arbel Y: Acute kidney injury among ST elevation myocardial infarction patients treated by primary percutaneous coronary intervention: A multifactorial entity. J Nephrol. 29:169–174. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Park KW, Koo BK, Kim HL, Kim YS, Jo SH, Lee HY, Kang HJ, Cho YS, Chung WY, Yeon TJ, et al: The incidence and predictors of contrast-induced nephropathy in adequately hydrated elderly patients with impaired renal function. Nephrol Dial Transplant. 22:1794–1795. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Persson PB and Tepel M: Contrast medium-induced nephropathy: The pathophysiology. Kidney Int Suppl. S8–S10. 2006. View Article : Google Scholar : PubMed/NCBI

20 

O'Donnell DH, Moloney MA, Bouchier-Hayes DJ and Lee MJ: Contrast-induced nephrotoxicity: Possible synergistic effect of stress hyperglycemia. AJR Am J Roentgenol. 195:W45–W49. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Goldstein DE, Little RR, Lorenz RA, Malone JI, Nathan DM and Peterson CM: American Diabetes Association: Tests of glycemia in diabetes. Diabetes Care. 27 Suppl 1:S91–S93. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Chinese Diabetes Society, . China Guideline For Type 2 Diabetes (2013 Edition). Chin J Diabet Mellitus. 6:447–498. 2014.(In Chinese).

23 

Azzalini L, Spagnoli V and Ly HQ: Contrast-induced nephropathy: From pathophysiology to preventive strategies. Can J Cardiol. 32:247–255. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Subramaniam RM, Suarez-Cuervo C, Wilson RF, Turban S, Zhang A, Sherrod C, Aboagye J, Eng J, Choi MJ, Hutfless S and Bass EB: Effectiveness of prevention strategies for contrast-induced nephropathy: A systematic review and meta-analysis. Ann Intern Med. 164:406–416. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qin YH, Yan GL, Ma CL, Tang CC and Ma GS: Effects of hyperglycaemia and elevated glycosylated haemoglobin on contrast‑induced nephropathy after coronary angiography. Exp Ther Med 16: 377-383, 2018.
APA
Qin, Y., Yan, G., Ma, C., Tang, C., & Ma, G. (2018). Effects of hyperglycaemia and elevated glycosylated haemoglobin on contrast‑induced nephropathy after coronary angiography. Experimental and Therapeutic Medicine, 16, 377-383. https://doi.org/10.3892/etm.2018.6183
MLA
Qin, Y., Yan, G., Ma, C., Tang, C., Ma, G."Effects of hyperglycaemia and elevated glycosylated haemoglobin on contrast‑induced nephropathy after coronary angiography". Experimental and Therapeutic Medicine 16.1 (2018): 377-383.
Chicago
Qin, Y., Yan, G., Ma, C., Tang, C., Ma, G."Effects of hyperglycaemia and elevated glycosylated haemoglobin on contrast‑induced nephropathy after coronary angiography". Experimental and Therapeutic Medicine 16, no. 1 (2018): 377-383. https://doi.org/10.3892/etm.2018.6183
Copy and paste a formatted citation
x
Spandidos Publications style
Qin YH, Yan GL, Ma CL, Tang CC and Ma GS: Effects of hyperglycaemia and elevated glycosylated haemoglobin on contrast‑induced nephropathy after coronary angiography. Exp Ther Med 16: 377-383, 2018.
APA
Qin, Y., Yan, G., Ma, C., Tang, C., & Ma, G. (2018). Effects of hyperglycaemia and elevated glycosylated haemoglobin on contrast‑induced nephropathy after coronary angiography. Experimental and Therapeutic Medicine, 16, 377-383. https://doi.org/10.3892/etm.2018.6183
MLA
Qin, Y., Yan, G., Ma, C., Tang, C., Ma, G."Effects of hyperglycaemia and elevated glycosylated haemoglobin on contrast‑induced nephropathy after coronary angiography". Experimental and Therapeutic Medicine 16.1 (2018): 377-383.
Chicago
Qin, Y., Yan, G., Ma, C., Tang, C., Ma, G."Effects of hyperglycaemia and elevated glycosylated haemoglobin on contrast‑induced nephropathy after coronary angiography". Experimental and Therapeutic Medicine 16, no. 1 (2018): 377-383. https://doi.org/10.3892/etm.2018.6183
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