Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development

  • Authors:
    • Xuena Cui
    • Jin'e Xu
    • Yuzhi Ji
    • Xiuhong Song
    • Junhuan Wang
    • Lijuan Zhang
    • Shengmei Yang
    • Yuanhua Ye
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China
    Copyright: © Cui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 197-203
    |
    Published online on: May 18, 2018
       https://doi.org/10.3892/etm.2018.6195
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to investigate the expression of the forkhead box protein M1 (FOXM1) in the placenta of patients with preeclampsia, and its effect on trophoblasts. A total of 28 patients with preeclampsia and 30 patients without preeclampsia (controls) who underwent cesarean section and were admitted to the Affiliated Hospital of Qingdao University between June 2013 and September 2016 were enrolled in the present study. The expression of FOXM1 in placental tissues was examined by reverse transcription‑quantitative polymerase chain reaction, western blotting and immunohistochemistry. HTR8/SVneo cells were used to measure the in vitro expression of the vascular endothelial growth factor (VEGF). The results demonstrated that FOXM1 expression was downregulated in the placental tissues of patient with preeclampsia (P<0.05). Following the silencing of FOXM1 expression, the proliferation of HTR8/SVneo cells was suppressed. The results of flow cytometry demonstrated that proportion of HTR8/SVneo cells in the G0/G1 phase and the proportion of apoptotic cells increased. The expression of the apoptosis regulator BCL‑2, as well as the expression of VEGF mRNA and protein expression were also downregulated following FOXM1 silencing. FOXM1 may therefore promote the development of preeclampsia via the VEGF signaling pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Cetin O, Ozdemir Guzel P, Kurdoglu Z and Sahin HG: Investigation of maternal psychopathological symptoms, dream anxiety and insomnia in preeclampsia. J Matern Fetal Neonatal Med. 30:2510–2515. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Baumwell S and Karumanchi SA: Preeclampsia: Clinical manifestations and molecular mechanisms. Nephron Clin Pract. 106:c72–c81. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Sones JL and Davisson RL: Preeclampsia, of mice and women. Physiol Genomics. 48:565–572. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Brooks SA, Martin E, Smeester L, Grace MR, Boggess K and Fry RC: miRNAs as common regulators of the transforming growth factor (TGF)-β pathway in the preeclamptic placenta and cadmium-treated trophoblasts: Links between the environment, the epigenome and preeclampsia. Food Chem Toxicol. 98:50–57. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Zuckerwise L, Li J, Lu L, Men Y, Geng T, Buhimschi CS, Buhimschi IA, Bukowski R, Guller S, Paidas M, et al: H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction. Oncotarget. 7:38398–38407. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Turner RJ, Bloemenkamp KW, Bruijn JA and Baelde HJ: Loss of thrombomodulin in placental dysfunction in preeclampsia. Arterioscler Thromb Vasc Biol. 36:728–735. 2016. View Article : Google Scholar : PubMed/NCBI

7 

van Eerden L, de Groot CJM, Zeeman GG, Page-Christiaens GCM, Pajkrt E, Duvekot JJ, Vandenbussche FP, Oei SG, Scheepers HCJ, van Eyck J, et al: Subsequent pregnancy outcome after mid-trimester termination of pregnancy for preeclampsia. Aust N Z J Obstet Gynaecol. Aug 29–2017.(Epub ahead of print). PubMed/NCBI

8 

Zhu H: Forkhead box transcription factors in embryonic heart development and congenital heart disease. Life Sci. 144:194–201. 2016. View Article : Google Scholar : PubMed/NCBI

9 

de Moraes Nestal G, Bella L, Zona S, Burton MJ and Lam EW: Insights into a critical role of the FOXO3a-FOXM1 Axis in DNA damage response and genotoxic drug resistance. Curr Drug Targets. 17:164–177. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Zona S, Bella L, Burton MJ, de Moraes Nestal G and Lam EW: FOXM1: An emerging master regulator of DNA damage response and genotoxic agent resistance. Biochim Biophys Acta. 1839:1316–1322. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Gao F, Bian F, Ma X, Kalinichenko VV and Das SK: Control of regional decidualization in implantation: Role of FoxM1 downstream of Hoxa10 and cyclin D3. Sci Rep. 5:138632015. View Article : Google Scholar : PubMed/NCBI

12 

Xie Y, Cui D, Sui L, Xu Y, Zhang N, Ma Y, Li Y and Kong Y: Induction of forkhead box M1 (FoxM1) by EGF through ERK signaling pathway promotes trophoblast cell invasion. Cell Tissue Res. 362:421–430. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Vaswani K, Hum MW, Chan HW, Ryan J, Wood-Bradley RJ, Nitert MD, Mitchell MD, Armitage JA and Rice GE: The effect of gestational age on angiogenic gene expression in the rat placenta. PLoS One. 8:e837622013. View Article : Google Scholar : PubMed/NCBI

14 

Li Y, Zhu H, Klausen C, Peng B and Leung PC: Vascular endothelial growth factor-A (VEGF-A) mediates activin A-induced human trophoblast Endothelial-Like tube formation. Endocrinology. 156:4257–4268. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Francis VA, Abera AB, Matjila M, Millar RP and Katz AA: Kisspeptin regulation of genes involved in cell invasion and angiogenesis in first trimester human trophoblast cells. PLoS One. 9:e996802014. View Article : Google Scholar : PubMed/NCBI

16 

Guo X, Feng L, Jia J, Chen R and Yu J: Upregulation of VEGF by small activating RNA and its implications in preeclampsia. Placenta. 46:38–44. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Chomczynski P and Sacchi N: The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: Twenty-something years on. Nat Protoc. 1:581–585. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Gan MF, Yang HL, Qian JL, Wu CS, Yuan CX, Li XF and Zou J: Comparison of two methods for RNA extraction from the nucleus pulposus of intervertebral discs. Genet Mol Res. 15:2016. View Article : Google Scholar

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Lu Y, Zhang K, Li C, Yao Y, Tao D, Liu Y, Zhang S and Ma Y: Piwil2 suppresses p53 by inducing phosphorylation of signal transducer and activator of transcription 3 in tumor cells. PLoS One. 7:e309992012. View Article : Google Scholar : PubMed/NCBI

21 

Shibata Y, Kikuchi R, Ishii H, Suzuki S, Harada K, Hirayama K, Suzuki A, Tatami Y, Kondo K and Murohara T: Balance between angiogenic and anti-angiogenic isoforms of VEGF-A is associated with the complexity and severity of coronary artery disease. Clin Chim Acta. 478:114–119. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Massimiani M, Salvi S, Piccirilli D, Vecchione L, Moresi S, Ferrazzani S, Stuhlmann H and Campagnolo L: A4. EGFL7 in placenta trophoblast and endothelial cells: Implications in the pathogenesis of preeclampsia. J Mater Fetal Neonatal Med. 29:42016. View Article : Google Scholar

23 

Shah DA and Khalil RA: Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia. Biochem Pharmacol. 95:211–226. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Nissaisorakarn P, Sharif S and Jim B: Hypertension in pregnancy: Defining blood pressure goals and the value of biomarkers for preeclampsia. Curr Cardiol Rep. 18:1312016. View Article : Google Scholar : PubMed/NCBI

25 

Goldman-Wohl DS and Yagel S: Examination of distinct fetal and maternal molecular pathways suggests a mechanism for the development of preeclampsia. J Reprod Immunol. 76:54–60. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Austgulen R: Recent knowledge on mechanisms underlying development of preeclampsia. Tidsskr Nor Laegeforen. 124:21–24. 2004.PubMed/NCBI

27 

Xuan RR, Niu TT and Chen HM: Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. Mol Med Rep. 14:2697–2704. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Bokslag A, van Weissenbruch M, Mol BW and de Groot CJ: Preeclampsia; short and long-term consequences for mother and neonate. Early Hum Dev. 102:47–50. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Gilani SI, Weissgerber TL, Garovic VD and Jayachandran M: Preeclampsia and extracellular vesicles. Curr Hypertens Rep. 18:682016. View Article : Google Scholar : PubMed/NCBI

30 

Karumanchi SA and Granger JP: Preeclampsia and pregnancy-related hypertensive disorders. Hypertension. 67:238–242. 2016.PubMed/NCBI

31 

Liu X, Hu Y, Zheng Y, Liu X, Luo M, Liu W, Zhao Y and Zou L: EPHB4 regulates human trophoblast cell line HTR-8/SVneo function: Implications for the role of EPHB4 in preeclampsia. Biol Reprod. 95:652016. View Article : Google Scholar : PubMed/NCBI

32 

Francica P, Nisa L, Aebersold DM, Langer R, Bladt F, Blaukat A, Stroka D, Martínez MR, Zimmer Y and Medová M: Depletion of FOXM1 via MET targeting underlies establishment of a DNA Damage-induced senescence program in gastric cancer. Clin Cancer Res. 22:5322–5336. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Xu MD, Wang Y, Weng W, Wei P, Qi P, Zhang Q, Tan C, Ni SJ, Dong L, Yang Y, et al: A positive feedback loop of lncRNA-PVT1 and FOXM1 facilitates gastric cancer growth and invasion. Clin Cancer Res. 23:2071–2080. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Sayanjali B, Christensen GJM, Al-Zeer MA, Mollenkopf HJ, Meyer TF and Brüggemann H: Propionibacterium acnes inhibits FOXM1 and induces cell cycle alterations in human primary prostate cells. Int J Med Microbiol. 306:517–528. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Maachani UB, Shankavaram U, Kramp T, Tofilon PJ, Camphausen K and Tandle AT: FOXM1 and STAT3 interaction confers radioresistance in glioblastoma cells. Oncotarget. 7:77365–77377. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Hackmon R, Pinnaduwage L, Zhang J, Lye SJ, Geraghty DE and Dunk CE: Definitive class I human leukocyte antigen expression in gestational placentation: HLA-F, HLA-E, HLA-C, and HLA-G in extravillous trophoblast invasion on placentation, pregnancy, and parturition. Am J Reprod Immunol. Feb 10–2017.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

37 

Jia Y, Li T, Huang X, Xu X, Zhou X, Jia L, Zhu J, Xie D, Wang K, Zhou Q, et al: Dysregulated DNA Methyltransferase 3A upregulates IGFBP5 to suppress trophoblast cell migration and invasion in preeclampsia. Hypertension. 69:356–366. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Ji L, Brkić J, Liu M, Fu G, Peng C and Wang YL: Placental trophoblast cell differentiation: Physiological regulation and pathological relevance to preeclampsia. Mol Aspects Med. 34:981–1023. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Kin K, Maziarz J, Chavan AR, Kamat M, Vasudevan S, Birt A, Emera D, Lynch VJ, Ott TL, Pavlicev M, et al: The transcriptomic evolution of mammalian pregnancy: Gene expression innovations in endometrial stromal fibroblasts. Genome Biol Evol. 8:2459–2473. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Knöfler M and Pollheimer J: IFPA Award in Placentology lecture: Molecular regulation of human trophoblast invasion. Placenta. 33 Suppl:S55–S62. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Roberts E, Cossigny DA and Quan GM: The role of vascular endothelial growth factor in metastatic prostate cancer to the skeleton. Prostate Cancer. 2013:4183402013. View Article : Google Scholar : PubMed/NCBI

42 

Ahmed A, Rezai H and Broadway-Stringer S: Evidence-Based revised view of the pathophysiology of preeclampsia. Adv Exp Med Biol. 956:355–374. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cui X, Xu J, Ji Y, Song X, Wang J, Zhang L, Yang S and Ye Y: Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development. Exp Ther Med 16: 197-203, 2018.
APA
Cui, X., Xu, J., Ji, Y., Song, X., Wang, J., Zhang, L. ... Ye, Y. (2018). Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development. Experimental and Therapeutic Medicine, 16, 197-203. https://doi.org/10.3892/etm.2018.6195
MLA
Cui, X., Xu, J., Ji, Y., Song, X., Wang, J., Zhang, L., Yang, S., Ye, Y."Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development". Experimental and Therapeutic Medicine 16.1 (2018): 197-203.
Chicago
Cui, X., Xu, J., Ji, Y., Song, X., Wang, J., Zhang, L., Yang, S., Ye, Y."Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development". Experimental and Therapeutic Medicine 16, no. 1 (2018): 197-203. https://doi.org/10.3892/etm.2018.6195
Copy and paste a formatted citation
x
Spandidos Publications style
Cui X, Xu J, Ji Y, Song X, Wang J, Zhang L, Yang S and Ye Y: Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development. Exp Ther Med 16: 197-203, 2018.
APA
Cui, X., Xu, J., Ji, Y., Song, X., Wang, J., Zhang, L. ... Ye, Y. (2018). Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development. Experimental and Therapeutic Medicine, 16, 197-203. https://doi.org/10.3892/etm.2018.6195
MLA
Cui, X., Xu, J., Ji, Y., Song, X., Wang, J., Zhang, L., Yang, S., Ye, Y."Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development". Experimental and Therapeutic Medicine 16.1 (2018): 197-203.
Chicago
Cui, X., Xu, J., Ji, Y., Song, X., Wang, J., Zhang, L., Yang, S., Ye, Y."Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development". Experimental and Therapeutic Medicine 16, no. 1 (2018): 197-203. https://doi.org/10.3892/etm.2018.6195
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team