Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2018 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2018 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Serum expression levels of Mb and NT‑proBNP and NF‑κB expression in neutrophils in patients with MODS and the clinical significance

  • Authors:
    • Congmei Wang
    • Qingliang Chen
    • Zhenyu Cui
    • Zhijing Xu
    • Yangang Shi
    • Shiqiong Su
    • Lu Qi
    • Yu'an Geng
    • Ruifang Liu
  • View Affiliations / Copyright

    Affiliations: ICU, The Third People's Provincial Hospital of Henan Province, Zhengzhou, Henan 466000, P.R. China, Department of Radiology, The Third People's Provincial Hospital of Henan Province, Zhengzhou, Henan 466000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4124-4128
    |
    Published online on: August 27, 2018
       https://doi.org/10.3892/etm.2018.6659
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

This study was designed to investigate the expression of myoglobin (Mb), N‑terminal pro‑brain natriuretic peptide (NT‑proBNP) in serum and the expression of nuclear factor‑κB (NF‑κB) in neutrophils in patients with multiple organ dysfun­ction syndrome (MODS) and the clinical significance. From July 2014 to December 2015, 314 patients with severe disease were selected during their stays at the emergency ward of the Third People's Provincial Hospital of Henan Province (Zhengzhou, China). Seventy patients with MODS were selected as MODS group, 108 patients with single organ or system injury were selected as the key prevention group, and 136 patients without obvious organ or systemic injury were selected as prevention group. Serum levels of Mb and NT‑proBNP were measured by ELISA. Neutrophils were isolated by flow cytometry, and the activity of NF‑κB in neutrophils of MODS patients was measured by electrophoretic mobility shift assay (EMSA). At 1, 7 and 14 days after treatment, the levels of Mb, NT‑proBNP and NF‑κB in the three groups were significantly reduced compared with pretreatment levels (p<0.05). Logistic regression analysis showed that serum Mb, NT‑proBNP and NF‑κB activity were positively correlated with the progression of the disease (r=0.809, 0.785 and 0.833, p=0.012, 0.025 and 0.004), and negatively correlated with the treatment time (r=‑0.773, ‑0.734 and ‑0.815; p=0.033, 0.041 and 0.078). Mb, NT‑proBNP and NF‑κB may be involved in the pathogenesis and development of MODS, and may play an important role in the prevention and treatment of MODS.
View Figures
View References

1 

Tamburro RF and Jenkins TL: Multiple organ dysfunction syndrome: A challenge for the pediatric critical care community. Pediatr Crit Care Med. 18 Suppl 1:S1–S3. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Cheng J, Wei Z, Liu X and Li X, Yuan Z, Zheng J, Chen X, Xiao G and Li X: The role of intestinal mucosa injury induced by intra-abdominal hypertension in the development of abdominal compartment syndrome and multiple organ dysfunction syndrome. Crit Care. 17:R283. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Roberts BW, Kilgannon JH, Chansky ME, Mittal N, Wooden J, Parrillo JE and Trzeciak S: Multiple organ dysfunction after return of spontaneous circulation in postcardiac arrest syndrome. Crit Care Med. 41:1492–1501. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Rajasekaran S, Kruse K, Kovey K, Davis AT, Hassan NE, Ndika AN, Zuiderveen S and Birmingham J: Therapeutic role of anakinra, an interleukin-1 receptor antagonist, in the management of secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction/macrophage activating syndrome in critically ill children*. Pediatr Crit Care Med. 15:401–408. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Bolli R, Tang XL, Sanganalmath SK, Rimoldi O, Mosna F, Abdel-Latif A, Jneid H, Rota M, Leri A and Kajstura J: Intracoronary delivery of autologous cardiac stem cells improves cardiac function in a porcine model of chronic ischemic cardiomyopathy. Circulation. 128:122–131. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Petejova N and Martinek A: Acute kidney injury due to rhabdomyolysis and renal replacement therapy: A critical review. Crit Care. 18:2242014. View Article : Google Scholar : PubMed/NCBI

7 

Mirjafari H, Welsh P, Verstappen SM, Wilson P, Marshall T, Edlin H, Bunn D, Chipping J, Lunt M, Symmons DP, et al: N-terminal pro-brain-type natriuretic peptide (NT-pro-BNP) and mortality risk in early inflammatory polyarthritis: Results from the Norfolk Arthritis Registry (NOAR). Ann Rheum Dis. 73:684–690. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Li N, Zhang Y, Fan S, Xing J and Liu H: BNP and NT-proBNP levels in patients with sepsis. Front Biosci (Landmark Ed). 18:1237–1243. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Metra M, Cotter G, Davison BA, Felker GM, Filippatos G, Greenberg BH, Ponikowski P, Unemori E, Voors AA, Adams KF Jr, et al: RELAX-AHF Investigators: Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) development program: Correlation with outcomes. J Am Coll Cardiol. 61:196–206. 2013. View Article : Google Scholar : PubMed/NCBI

10 

De Simone V, Franzè E, Ronchetti G, Colantoni A, Fantini MC, Di Fusco D, Sica GS, Sileri P, MacDonald TT, Pallone F, et al: Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene. 34:3493–3503. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Garding A, Bhattacharya N, Claus R, Ruppel M, Tschuch C, Filarsky K, Idler I, Zucknick M, Caudron-Herger M, Oakes C, et al: Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the in cis downregulation of a gene cluster that targets NF-kB. PLoS Genet. 9:e10033732013. View Article : Google Scholar : PubMed/NCBI

12 

Wang C, Su Q, Zhang SW, Yin CH, Wang H and Wang BE: A clinical study on the diagnostic criteria of multiple organ dysfunction syndrome. Zhonghua Wai Ke Za Zhi. 47:40–43. 2009.(In Chinese). PubMed/NCBI

13 

El-Hattab AW, Adesina AM, Jones J and Scaglia F: MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options. Mol Genet Metab. 116:4–12. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Szijártó A, Turóczi Z, Szabó J, Kaliszky P, Gyurkovics E, Arányi P, Regáli L, Harsányi L and Lotz G: Rapidly progressing fatal reperfusion syndrome caused by acute critical ischemia of the lower limb. Cardiovasc Pathol. 22:493–500. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Hebbel RP: Ischemia-reperfusion injury in sickle cell anemia: Relationship to acute chest syndrome, endothelial dysfunction, arterial vasculopathy, and inflammatory pain. Hematol Oncol Clin North Am. 28:181–198. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Davies KJA: Oxidative Damage and Repair: Chemical, Biological and Medical Aspects. 1st. Pergamon Press, Inc.; New York: 2013

17 

Fan Z, Yao J, Li Y, Hu X, Shao H and Tian X: Anti-inflammatory and antioxidant effects of curcumin on acute lung injury in a rodent model of intestinal ischemia reperfusion by inhibiting the pathway of NF-Kb. Int J Clin Exp Pathol. 8:3451–3459. 2015.PubMed/NCBI

18 

Licata A, Corrao S, Petta S, Genco C, Cardillo M, Calvaruso V, Cabibbo G, Massenti F, Cammà C, Licata G, et al: NT pro BNP plasma level and atrial volume are linked to the severity of liver cirrhosis. PLoS One. 8:e683642013. View Article : Google Scholar : PubMed/NCBI

19 

Mishra RK, Li Y, Ricardo AC, Yang W, Keane M, Cuevas M, Christenson R, deFilippi C, Chen J, He J, et al: Chronic Renal Insufficiency Cohort Investigators: Association of N-terminal pro-B-type natriuretic peptide with left ventricular structure and function in chronic kidney disease [from the Chronic Renal Insufficiency Cohort (CRIC)]. Am J Cardiol. 111:432–438. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang C, Chen Q, Cui Z, Xu Z, Shi Y, Su S, Qi L, Geng Y and Liu R: Serum expression levels of Mb and NT‑proBNP and NF‑κB expression in neutrophils in patients with MODS and the clinical significance. Exp Ther Med 16: 4124-4128, 2018.
APA
Wang, C., Chen, Q., Cui, Z., Xu, Z., Shi, Y., Su, S. ... Liu, R. (2018). Serum expression levels of Mb and NT‑proBNP and NF‑κB expression in neutrophils in patients with MODS and the clinical significance. Experimental and Therapeutic Medicine, 16, 4124-4128. https://doi.org/10.3892/etm.2018.6659
MLA
Wang, C., Chen, Q., Cui, Z., Xu, Z., Shi, Y., Su, S., Qi, L., Geng, Y., Liu, R."Serum expression levels of Mb and NT‑proBNP and NF‑κB expression in neutrophils in patients with MODS and the clinical significance". Experimental and Therapeutic Medicine 16.5 (2018): 4124-4128.
Chicago
Wang, C., Chen, Q., Cui, Z., Xu, Z., Shi, Y., Su, S., Qi, L., Geng, Y., Liu, R."Serum expression levels of Mb and NT‑proBNP and NF‑κB expression in neutrophils in patients with MODS and the clinical significance". Experimental and Therapeutic Medicine 16, no. 5 (2018): 4124-4128. https://doi.org/10.3892/etm.2018.6659
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Chen Q, Cui Z, Xu Z, Shi Y, Su S, Qi L, Geng Y and Liu R: Serum expression levels of Mb and NT‑proBNP and NF‑κB expression in neutrophils in patients with MODS and the clinical significance. Exp Ther Med 16: 4124-4128, 2018.
APA
Wang, C., Chen, Q., Cui, Z., Xu, Z., Shi, Y., Su, S. ... Liu, R. (2018). Serum expression levels of Mb and NT‑proBNP and NF‑κB expression in neutrophils in patients with MODS and the clinical significance. Experimental and Therapeutic Medicine, 16, 4124-4128. https://doi.org/10.3892/etm.2018.6659
MLA
Wang, C., Chen, Q., Cui, Z., Xu, Z., Shi, Y., Su, S., Qi, L., Geng, Y., Liu, R."Serum expression levels of Mb and NT‑proBNP and NF‑κB expression in neutrophils in patients with MODS and the clinical significance". Experimental and Therapeutic Medicine 16.5 (2018): 4124-4128.
Chicago
Wang, C., Chen, Q., Cui, Z., Xu, Z., Shi, Y., Su, S., Qi, L., Geng, Y., Liu, R."Serum expression levels of Mb and NT‑proBNP and NF‑κB expression in neutrophils in patients with MODS and the clinical significance". Experimental and Therapeutic Medicine 16, no. 5 (2018): 4124-4128. https://doi.org/10.3892/etm.2018.6659
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team