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Serum PPARγ level and PPARγ gene polymorphism as well as severity and prognosis of brain injury in patients with arteriosclotic cerebral infarction

  • Authors:
    • Weiming Wei
    • Xuwen Chen
    • Xueying Lin
    • Fulan Shan
    • Shaopeng Lin
    • Qingyu Shen
    • Li Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Zengcheng District People's Hospital of Guangzhou, Guangzhou, Guangdong 511300, P.R. China, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510260, P.R. China, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510000, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4058-4062
    |
    Published online on: August 28, 2018
       https://doi.org/10.3892/etm.2018.6660
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Abstract

The aim of the study was to study the serum peroxisome proliferator-activated receptor gamma (PPARγ) level and PPARγ gene polymorphism as well as the severity and prognosis of brain injury in patients with arteriosclotic cerebral infarction (ACI). A total of 246 ACI patients presenting at the Department of Neurology of Zengcheng District People's Hospital of Guangzhou between April 2009 and July 2015 were selected as the case group, and 382 control subjects were enrolled as the control group. The hepatic and renal functions and homocysteine (Hcy) expression levels were measured. Enzyme-linked immunosorbent assay (ELISA) kit was used to detect the serum PPARγ levels of the ACI patients. Polymerase chain reaction-restriction fragment length polymorphism method was applied to measure the PPARγ gene polymorphism. The proportions of hypertension patients, diabetes patients and smoking people in the case group were significantly higher than those in the control group. The levels of cholesterol and fasting blood glucose in the case group were elevated obviously compared with those in the control group. The levels of indexes related to the hepatic function and renal function in the case group were remarkably higher than those in the control group. The serum PPARγ levels were increased progressively at acute stage. The distribution frequencies of PPARγ genotypes CC, CT and TT in the case group were higher than those in the control group; compared with that in the control group, the proportion of C allele in the case group was raised obviously, while that of T allele was significantly decreased. The serum PPARγ level has a close correlation with the PPARγ gene polymorphism in ACI patients, and PPARγ is also remarkably related to the severity of brain injury; therefore, PPARγ has great significance in the diagnosis and treatment of cerebral infarction.
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Copy and paste a formatted citation
Spandidos Publications style
Wei W, Chen X, Lin X, Shan F, Lin S, Shen Q and Zhang L: Serum PPARγ level and PPARγ gene polymorphism as well as severity and prognosis of brain injury in patients with arteriosclotic cerebral infarction. Exp Ther Med 16: 4058-4062, 2018.
APA
Wei, W., Chen, X., Lin, X., Shan, F., Lin, S., Shen, Q., & Zhang, L. (2018). Serum PPARγ level and PPARγ gene polymorphism as well as severity and prognosis of brain injury in patients with arteriosclotic cerebral infarction. Experimental and Therapeutic Medicine, 16, 4058-4062. https://doi.org/10.3892/etm.2018.6660
MLA
Wei, W., Chen, X., Lin, X., Shan, F., Lin, S., Shen, Q., Zhang, L."Serum PPARγ level and PPARγ gene polymorphism as well as severity and prognosis of brain injury in patients with arteriosclotic cerebral infarction". Experimental and Therapeutic Medicine 16.5 (2018): 4058-4062.
Chicago
Wei, W., Chen, X., Lin, X., Shan, F., Lin, S., Shen, Q., Zhang, L."Serum PPARγ level and PPARγ gene polymorphism as well as severity and prognosis of brain injury in patients with arteriosclotic cerebral infarction". Experimental and Therapeutic Medicine 16, no. 5 (2018): 4058-4062. https://doi.org/10.3892/etm.2018.6660
Copy and paste a formatted citation
x
Spandidos Publications style
Wei W, Chen X, Lin X, Shan F, Lin S, Shen Q and Zhang L: Serum PPARγ level and PPARγ gene polymorphism as well as severity and prognosis of brain injury in patients with arteriosclotic cerebral infarction. Exp Ther Med 16: 4058-4062, 2018.
APA
Wei, W., Chen, X., Lin, X., Shan, F., Lin, S., Shen, Q., & Zhang, L. (2018). Serum PPARγ level and PPARγ gene polymorphism as well as severity and prognosis of brain injury in patients with arteriosclotic cerebral infarction. Experimental and Therapeutic Medicine, 16, 4058-4062. https://doi.org/10.3892/etm.2018.6660
MLA
Wei, W., Chen, X., Lin, X., Shan, F., Lin, S., Shen, Q., Zhang, L."Serum PPARγ level and PPARγ gene polymorphism as well as severity and prognosis of brain injury in patients with arteriosclotic cerebral infarction". Experimental and Therapeutic Medicine 16.5 (2018): 4058-4062.
Chicago
Wei, W., Chen, X., Lin, X., Shan, F., Lin, S., Shen, Q., Zhang, L."Serum PPARγ level and PPARγ gene polymorphism as well as severity and prognosis of brain injury in patients with arteriosclotic cerebral infarction". Experimental and Therapeutic Medicine 16, no. 5 (2018): 4058-4062. https://doi.org/10.3892/etm.2018.6660
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