Effects of milrinone on serum IL‑6, TNF‑α, Cys‑C and cardiac functions of patients with chronic heart failure

Shao,Tingguo; Zhang,Yuqing; Tang,Rubo; Zhang,Hai; Wang,Quanzheng; Yang,Ying; Liu,Tongxiang

doi:10.3892/etm.2018.6672

November-2018 Volume 16 Issue 5

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November-2018 Volume 16 Issue 5

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Article Open Access

Effects of milrinone on serum IL‑6, TNF‑α, Cys‑C and cardiac functions of patients with chronic heart failure

Authors:
- Tingguo Shao
- Yuqing Zhang
- Rubo Tang
- Hai Zhang
- Quanzheng Wang
- Ying Yang
- Tongxiang Liu
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Affiliations: Department of Cardiology, Dongcheng Branch, Shouguang People's Hospital, Weifang, Shandong 262704, P.R. China, Department of Vasculocardiology, Shouguang People's Hospital, Weifang, Shandong 262700, P.R. China, Emergency Department, Shouguang People's Hospital, Weifang, Shandong 262700, P.R. China, Regular Physical Examination Centre, Shouguang People's Hospital, Weifang, Shandong 262700, P.R. China, Emergency Department, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China

Copyright: © Shao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 4162-4166
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Published online on: August 31, 2018

https://doi.org/10.3892/etm.2018.6672
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Abstract

Effects of milrinone on serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), cystatin C (Cys-C) and cardiac functions of patients with chronic heart failure were analyzed to investigate the value of milrinone in chronic heart failure. A total of 70 patients diagnosed with chronic heart failure were selected and randomly divided into treatment group (n=35) and control group (n=35). All patients were treated with conventional anti‑heart failure therapy, and patients in the treatment group received milrinone on the basis of conventional therapy. The general data of patients, such as age, sex and course of chronic heart failure, were collected; the levels of serum IL‑6, TNF‑α and Cys‑C before and after treatment were compared between the groups, and the cardiac function indexes were also compared, including cardiac output (CO), stroke volume (SV), left ventricular ejection fraction (LVEF), left ventricular end‑diastolic diameter (LVDd), left ventricular end‑systolic diameter (LVSd) and brain natriuretic peptide (BNP) level. Besides, the curative effects and adverse reactions in the two groups were recorded. The results revealed that serum IL‑6, TNF‑α and Cys‑C levels had no significant difference between the two groups before treatment; however, the curative effect in the treatment group was significantly superior to that in control group (p<0.05); after treatment, CO, SV and LVEF in both groups were obviously increased, but LVDd, LVSd and BNP levels were obviously decreased; the curative effect in the treatment group was significantly superior to that in control group (p<0.05); heart rate in both groups was obviously decreased after treatment (p<0.05); the total effective rate in the treatment group was significantly higher than that in control group after treatment (p<0.05). In conclusion, based on the conventional anti‑heart failure therapy, the application of milrinone can reduce the serum IL‑6, TNF‑α and Cys‑C levels and improve the cardiac functions of patients effectively.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effects of milrinone on serum IL‑6, TNF‑α, Cys‑C and cardiac functions of patients with chronic heart failure

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