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Article

Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway

  • Authors:
    • Feng‑Yi Yuan
    • Min Zhang
    • Ping Xu
    • Dan Xu
    • Ping Chen
    • Min Ren
    • Qin Sun
    • Jing‑Yan Chen
    • Juan Du
    • Xia‑Lian Tang
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology and Metabolism, Second Affiliated Hospital of Jinan University, Shenzhen, Guangdong 518020, P.R. China, Geriatric Department of Endocrinology, Sichuan Province People's Hospital and Sichuan Academy of Medical Sciences, Chengdu, Sichuan 610072, P.R. China
  • Pages: 4225-4231
    |
    Published online on: September 3, 2018
       https://doi.org/10.3892/etm.2018.6674
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Abstract

Diabetes mellitus (DM) is a systemic metabolic disease. Tanshinone IIA (Tan‑IIA) presents potential benefits for DM. The purpose of this study was to investigate the efficacy of Tan‑IIA in type 2 DM rats and explore its potential mechanism in renal cells. A type 2 DM rat model was established and administered with Tan‑IIA or PBS. It was demonstrated that Tan‑IIA treatment significantly reduced levels of total cholesterol, non‑esterified fatty acids, total triglyceride and low‑density lipoprotein cholesterol in experimental DM rats compared with the control group. The results indicated that Tan‑IIA treatment significantly decreased levels of interleukin (IL)‑8, tumor necrosis factor‑α, C‑reactive protein and IL‑6. It was identified that Tan‑IIA treatment significantly decreased nuclear factor‑κB levels and significantly elevated 5' adenosine monophosphate‑activated protein kinase levels. Western blot analysis indicated that Tan‑IIA elevated immunocyte precipitation in renal cells. Furthermore, Tan‑IIA treatment improved lipid metabolism, glucose metabolism, insulin resistance and body weight of type 2 DM rats. In conclusion, Tan‑IIA administration may inhibit inflammatory cytokines and alleviate type 2 DM symptoms in experimental rats.
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1 

Bgeginski R, Ribeiro PAB, Mottola MF and Ramos JGL: Effects of weekly supervised exercise or physical activity counseling on fasting blood glucose in women diagnosed with gestational diabetes mellitus: A systematic review and meta-analysis of randomized trials. J Diabetes. 9:1023–1032. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Moosazadeh M, Asemi Z, Lankarani KB, Tabrizi R, Maharlouei N, Naghibzadeh-Tahami A, Yousefzadeh G, Sadeghi R, Khatibi SR, Afshari M, et al: Family history of diabetes and the risk of gestational diabetes mellitus in Iran: A systematic review and meta-analysis. Diabetes Metab Syndr. 11 Suppl 1:S99–S104. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Gyawali B, Ferrario A, van Teijlingen E and Kallestrup P: Challenges in diabetes mellitus type 2 management in Nepal: A literature review. Glob Health Action. 9:317042016. View Article : Google Scholar : PubMed/NCBI

4 

Mustafa SB, Mehmood Z, Akhter N, Kauser A, Hussain I, Rashid A, Akram M, Tahir IM, Munir N, Riaz M, et al: Review-medicinal plants and management of diabetes mellitus: A review. Pak J Pharm Sci. 29 Suppl 5:S1885–S1891. 2016.

5 

Gomes JMG, Costa JA and Alfenas RCG: Metabolic endotoxemia and diabetes mellitus: A systematic review. Metabolism. 68:133–144. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Mizamtsidi M, Paschou SA, Grapsa J and Vryonidou A: Diabetic cardiomyopathy: A clinical entity or a cluster of molecular heart changes? Eur J Clin Invest. 46:947–953. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Shang Y, Zhang X, Chen L, Leng W, Lei X, Yang Q, Liang Z and Wang J: Assessment of left ventricular structural remodelling in patients with diabetic cardiomyopathy by cardiovascular magnetic resonance. J Diabetes Res. 2016:47869252016. View Article : Google Scholar : PubMed/NCBI

8 

Feng J, Li S and Chen H: Tanshinone IIA inhibits myocardial remodeling induced by pressure overload via suppressing oxidative stress and inflammation: Possible role of silent information regulator 1. Eur J Pharmacol. 791:632–639. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Shu M, Hu XR, Hung ZA, Huang DD and Zhang S: Effects of tanshinone IIA on fibrosis in a rat model of cirrhosis through heme oxygenase-1, inflammation, oxidative stress and apoptosis. Mol Med Rep. 13:3036–3042. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Lu Q, Zhang P, Zhang X and Chen J: Experimental study of the anti-cancer mechanism of tanshinone IIA against human breast cancer. Int J Mol Med. 24:773–780. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Xu M, Cao FL, Zhang YF, Shan L, Jiang XL, An XJ, Xu W, Liu XZ and Wang XY: Tanshinone IIA therapeutically reduces LPS-induced acute lung injury by inhibiting inflammation and apoptosis in mice. Acta Pharmacol Sin. 36:179–187. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Wang DT, Huang RH, Cheng X, Zhang ZH, Yang YJ and Lin X: Tanshinone IIA attenuates renal fibrosis and inflammation via altering expression of TGF-β/Smad and NF-kappaB signaling pathway in 5/6 nephrectomized rats. Int Immunopharmacol. 26:4–12. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Han F, Sheng L, Jian Q and Weng Q: Therapeutic effects of Tanshinone IIA towards early renal damage in patients with type 2 diabetes. West Indian Med J. 2016. View Article : Google Scholar

14 

Karabulut A, Akyer SP, Mete Abban G and Sahin B: Effects of menopause, diabetes mellitus and steroid use on type I mesh-induced tissue reaction in a rat model. Eur J Obstet Gynecol Reprod Biol. 179:27–31. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Galea R, Wells RG, Ross CK, Lockwood J, Moore K, Harvey JT and Isensee GH: A comparison of rat SPECT images obtained using 99mTc derived from 99Mo produced by an electron accelerator with that from a reactor. Phys Med Biol. 58:2737–2750. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Arbillaga L, Vettorazzi A, Gil AG, van Delft JH, García-Jalón JA and de Cerain López A: Gene expression changes induced by ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration. Toxicol Appl Pharmacol. 230:197–207. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Hu H, Xu S, Hu S, Gao Y and Shui H: Effect of 1,25(OH)2D3 on transdifferentiation of rat renal tubular epithelial cells induced by high glucose. Biomed Rep. 5:699–704. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Myers J: Antigen retrieval: A review of commonly used methods and devices. MLO Med Lab Obs. 38(10): 12–15; quiz 16–17. 2006.

19 

Barami K, Lyon L and Conell C: Type 2 diabetes mellitus and glioblastoma multiforme-assessing risk and survival: Results of a large retrospective study and systematic review of the literature. World Neurosurg. 106:300–307. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Li YH, Xu Q, Xu WH, Guo XH, Zhang S and Chen YD: Mechanisms of protection against diabetes-induced impairment of endothelium-dependent vasorelaxation by Tanshinone IIA. Biochim Biophys Acta. 1850:813–823. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Jiang P, Li C, Xiang Z and Jiao B: Tanshinone IIA reduces the risk of Alzheimer's disease by inhibiting iNOS, MMP2 and NFkappaBp65 transcription and translation in the temporal lobes of rat models of Alzheimer's disease. Mol Med Rep. 10:689–694. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Hamar P: Role of regulatory micro RNAs in type 2 diabetes mellitus-related inflammation. Nucleic Acid Ther. 22:289–294. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Van Sickle BJ, Simmons J, Hall R, Raines M, Ness K and Spagnoli A: Increased circulating IL-8 is associated with reduced IGF-1 and related to poor metabolic control in adolescents with type 1 diabetes mellitus. Cytokine. 48:290–294. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Chen YL, Qiao YC, Xu Y, Ling W, Pan YH, Huang YC, Geng LJ, Zhao HL and Zhang XX: Serum TNF-α concentrations in type 2 diabetes mellitus patients and diabetic nephropathy patients: A systematic review and meta-analysis. Immunol Lett. 186:52–58. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Kawada T: C-reactive protein, depressive symptoms and incident diabetes mellitus with special emphasis on physical activity. J Psychosom Res. 78:4072015. View Article : Google Scholar : PubMed/NCBI

26 

Darko SN, Yar DD, Owusu-Dabo E, Awuah AA, Dapaah W, Addofoh N, Salifu SP, Awua-Boateng NY and Adomako-Boateng F: Variations in levels of IL-6 and TNF-α in type 2 diabetes mellitus between rural and urban Ashanti Region of Ghana. BMC Endocr Disord. 15:502015. View Article : Google Scholar : PubMed/NCBI

27 

Khosrozadeh M, Heydari N and Abootalebi M: The effect of Abelmoschus Esculentus on blood levels of glucose in diabetes mellitus. Iran J Med Sci. 41:S632016.

28 

Javadi S, Asri-Rezaei S and Allahverdizadeh M: Interrelationship of beta-2 microglobulin, blood urea nitrogen and creatinine in streptozotocin-induced diabetes mellitus in rabbits. Vet Res Forum. 5:7–11. 2014.PubMed/NCBI

29 

van Olden C, Groen AK and Nieuwdorp M: Role of intestinal microbiome in lipid and glucose metabolism in diabetes mellitus. Clin Ther. 37:1172–1177. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Zhong L, Luo Y, Huang C and Liu L: Effect of NF-kB decoy on insulin resistance of adipocytes from patients with type 2 diabetes mellitus. Diabetes Metabol. 37:520–526. 2011. View Article : Google Scholar

31 

Cai S, Sun W, Fan Y, Guo X, Xu G, Xu T, Hou Y, Zhao B, Feng X and Liu T: Effect of mulberry leaf (Folium Mori) on insulin resistance via IRS-1/PI3K/Glut-4 signalling pathway in type 2 diabetes mellitus rats. Pharm Biol. 54:2685–2691. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Yao L, Wan J, Li H, Ding J, Wang Y, Wang X and Li M: Resveratrol relieves gestational diabetes mellitus in mice through activating AMPK. Reprod Biol Endocrinol. 13:1182015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yuan FY, Zhang M, Xu P, Xu D, Chen P, Ren M, Sun Q, Chen JY, Du J, Tang XL, Tang XL, et al: Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway. Exp Ther Med 16: 4225-4231, 2018.
APA
Yuan, F., Zhang, M., Xu, P., Xu, D., Chen, P., Ren, M. ... Tang, X. (2018). Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway. Experimental and Therapeutic Medicine, 16, 4225-4231. https://doi.org/10.3892/etm.2018.6674
MLA
Yuan, F., Zhang, M., Xu, P., Xu, D., Chen, P., Ren, M., Sun, Q., Chen, J., Du, J., Tang, X."Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway". Experimental and Therapeutic Medicine 16.5 (2018): 4225-4231.
Chicago
Yuan, F., Zhang, M., Xu, P., Xu, D., Chen, P., Ren, M., Sun, Q., Chen, J., Du, J., Tang, X."Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway". Experimental and Therapeutic Medicine 16, no. 5 (2018): 4225-4231. https://doi.org/10.3892/etm.2018.6674
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan FY, Zhang M, Xu P, Xu D, Chen P, Ren M, Sun Q, Chen JY, Du J, Tang XL, Tang XL, et al: Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway. Exp Ther Med 16: 4225-4231, 2018.
APA
Yuan, F., Zhang, M., Xu, P., Xu, D., Chen, P., Ren, M. ... Tang, X. (2018). Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway. Experimental and Therapeutic Medicine, 16, 4225-4231. https://doi.org/10.3892/etm.2018.6674
MLA
Yuan, F., Zhang, M., Xu, P., Xu, D., Chen, P., Ren, M., Sun, Q., Chen, J., Du, J., Tang, X."Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway". Experimental and Therapeutic Medicine 16.5 (2018): 4225-4231.
Chicago
Yuan, F., Zhang, M., Xu, P., Xu, D., Chen, P., Ren, M., Sun, Q., Chen, J., Du, J., Tang, X."Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway". Experimental and Therapeutic Medicine 16, no. 5 (2018): 4225-4231. https://doi.org/10.3892/etm.2018.6674
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