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Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function

  • Authors:
    • Xianmin Meng
    • Yongguo Li
    • Hong Luan
    • Xiuyan Shi
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China, Affiliated Hospital of Taishan Medical University, Tai'an, Shandong 271000, P.R. China
    Copyright: © Meng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3909-3912
    |
    Published online on: September 3, 2018
       https://doi.org/10.3892/etm.2018.6676
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Abstract

Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum (CA) was investigated to explore its effect on immune function. A total of 104 patients with anal CA were randomly divided into two groups: Patients in the study group were treated with photodynamic therapy combined with imiquimod, and ii) patients in the control group were treated with recombinant human interferon α-2b cream. Clinical efficacy and immune function related indicators were compared between the two groups. After treatment for 6 weeks, the cure rate and total effective rate of study group was 53.85 and 92.31%, respectively, which were significantly higher than those of the control group (30.77 and 75.00%, P<0.05). Recurrence rate of study group was 3.85% within 6 months after treatment, which was significantly lower than that of the control group (19.23%, P<0.05). After treatment, levels of CD4+, CD4+/CD8+ and IFN-γ in the study group were significantly higher than those in the control group, and levels of CD8+, IL-4 and IL-10 in the study group were significantly lower than those in the control group (P<0.05). Photodynamic therapy combined with imiquimod in the treatment of anus CA can regulate T lymphocyte subsets and cytokine levels, enhance immune function, improve clinical efficacy, reduce recurrence rate, and have almost no side effects. Therefore, this treatment should be popularized in clinical practice.
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Copy and paste a formatted citation
Spandidos Publications style
Meng X, Li Y, Luan H and Shi X: Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function. Exp Ther Med 16: 3909-3912, 2018.
APA
Meng, X., Li, Y., Luan, H., & Shi, X. (2018). Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function. Experimental and Therapeutic Medicine, 16, 3909-3912. https://doi.org/10.3892/etm.2018.6676
MLA
Meng, X., Li, Y., Luan, H., Shi, X."Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function". Experimental and Therapeutic Medicine 16.5 (2018): 3909-3912.
Chicago
Meng, X., Li, Y., Luan, H., Shi, X."Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function". Experimental and Therapeutic Medicine 16, no. 5 (2018): 3909-3912. https://doi.org/10.3892/etm.2018.6676
Copy and paste a formatted citation
x
Spandidos Publications style
Meng X, Li Y, Luan H and Shi X: Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function. Exp Ther Med 16: 3909-3912, 2018.
APA
Meng, X., Li, Y., Luan, H., & Shi, X. (2018). Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function. Experimental and Therapeutic Medicine, 16, 3909-3912. https://doi.org/10.3892/etm.2018.6676
MLA
Meng, X., Li, Y., Luan, H., Shi, X."Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function". Experimental and Therapeutic Medicine 16.5 (2018): 3909-3912.
Chicago
Meng, X., Li, Y., Luan, H., Shi, X."Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function". Experimental and Therapeutic Medicine 16, no. 5 (2018): 3909-3912. https://doi.org/10.3892/etm.2018.6676
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