Open Access

Regulatory T‑cell density and cytotoxic T lymphocyte density are associated with complete response to neoadjuvant paclitaxel and carboplatin chemoradiotherapy in gastric cancer

  • Authors:
    • Di Huang
    • Yongjiang Yang
    • Shuai Zhang
    • Zhuobin Su
    • Tao Peng
    • Xiaoyuan Wang
    • Yifeng Zhao
    • Shuguang Li
  • View Affiliations

  • Published online on: September 3, 2018     https://doi.org/10.3892/etm.2018.6684
  • Pages: 3813-3820
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Regulatory T-cell density and cytotoxic T lymphocyte density are crucial in regulating antitumor immune responses. Tumor infiltration has marked therapeutic effects in gastric carcinoma, and there is evidence that chemoradiotherapy (CRT) exhibits an immune‑mediated component. In the present study, the density of CD4+ and CD8+ cells were evaluated in post‑CRT surgical samples from 68 patients with gastric cancer using immunohistochemistry. The associations between T‑cell density, cytotoxic T lymphocyte density and clinical survival rate were also analyzed. Cytotoxic T lymphocyte density was associated with gastric carcinoma regression grade and regulatory T‑cell density was also associated with gastric carcinoma regression grade. Of the patients who had a pathologic complete response, 84 and 76% were found to have a high CD3+ and CD4+ cell density, which was significantly different to patients who had a low CD3+ and CD4+ cell density. High cytotoxic T lymphocyte density was also associated with improved survival rates of patients with gastric cancer. In conclusion, these outcomes indicated that regulatory T‑cell density and cytotoxic T lymphocyte density in the tumor microenvironment were associated with the response to neoadjuvant CRT and may represent a therapeutic target for gastric cancer.
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November-2018
Volume 16 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Huang D, Yang Y, Zhang S, Su Z, Peng T, Wang X, Zhao Y and Li S: Regulatory T‑cell density and cytotoxic T lymphocyte density are associated with complete response to neoadjuvant paclitaxel and carboplatin chemoradiotherapy in gastric cancer. Exp Ther Med 16: 3813-3820, 2018
APA
Huang, D., Yang, Y., Zhang, S., Su, Z., Peng, T., Wang, X. ... Li, S. (2018). Regulatory T‑cell density and cytotoxic T lymphocyte density are associated with complete response to neoadjuvant paclitaxel and carboplatin chemoradiotherapy in gastric cancer. Experimental and Therapeutic Medicine, 16, 3813-3820. https://doi.org/10.3892/etm.2018.6684
MLA
Huang, D., Yang, Y., Zhang, S., Su, Z., Peng, T., Wang, X., Zhao, Y., Li, S."Regulatory T‑cell density and cytotoxic T lymphocyte density are associated with complete response to neoadjuvant paclitaxel and carboplatin chemoradiotherapy in gastric cancer". Experimental and Therapeutic Medicine 16.5 (2018): 3813-3820.
Chicago
Huang, D., Yang, Y., Zhang, S., Su, Z., Peng, T., Wang, X., Zhao, Y., Li, S."Regulatory T‑cell density and cytotoxic T lymphocyte density are associated with complete response to neoadjuvant paclitaxel and carboplatin chemoradiotherapy in gastric cancer". Experimental and Therapeutic Medicine 16, no. 5 (2018): 3813-3820. https://doi.org/10.3892/etm.2018.6684