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Annexin A2 and FTH1 are potential biomarkers for lupus nephritis

  • Authors:
    • Yanni Zhou
    • Liangxiang Xiao
    • Shuifu Tang
  • View Affiliations / Copyright

    Affiliations: Division of Nephrology, Xiamen Hospital of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Xiamen, Fujian 361000, P.R. China, Division of Nephrology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, Fujian 361004, P.R. China, Division of Nephrology, First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3766-3776
    |
    Published online on: September 4, 2018
       https://doi.org/10.3892/etm.2018.6686
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Abstract

Lupus nephritis (LN) occurs in ~50% of patients with systemic lupus erythematosus and is a major cause of morbidity and mortality of the affected individuals. Therefore, identification of novel and predictive biomarkers for the early diagnosis and progression of LN is required. The present study included 10 patients with LN whose diagnoses were confirmed by renal biopsy and 5 healthy participants as control subjects. Sera were collected both from patients with LN and healthy controls. Subsequently, mesangial cells were treated with these sera for 24 h. Differential proteins between groups were detected by two‑dimensional difference gel electrophoresis (2D‑DIGE) and matrix‑assisted laser desorption/ionization time of flight mass spectrometry analysis. 2D‑DIGE maps of cellar proteins were obtained for LN and normal control groups. A total of 45 proteins were characterized, and 2 low‑abundance proteins were identified. Compared with the normal human sera group, expression level of Annexin A2 was elevated in patients with LN, while the expression of the ferritin heavy chain (FTH1) decreased in the LN group; the analysis was carried out by DeCyder version 7.0 automatically. The results of the present study suggest that Annexin A2 and FTH1 contributed to the progression of LN and could serve as potential biomarkers for this disease.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou Y, Xiao L and Tang S: Annexin A2 and FTH1 are potential biomarkers for lupus nephritis. Exp Ther Med 16: 3766-3776, 2018.
APA
Zhou, Y., Xiao, L., & Tang, S. (2018). Annexin A2 and FTH1 are potential biomarkers for lupus nephritis. Experimental and Therapeutic Medicine, 16, 3766-3776. https://doi.org/10.3892/etm.2018.6686
MLA
Zhou, Y., Xiao, L., Tang, S."Annexin A2 and FTH1 are potential biomarkers for lupus nephritis". Experimental and Therapeutic Medicine 16.5 (2018): 3766-3776.
Chicago
Zhou, Y., Xiao, L., Tang, S."Annexin A2 and FTH1 are potential biomarkers for lupus nephritis". Experimental and Therapeutic Medicine 16, no. 5 (2018): 3766-3776. https://doi.org/10.3892/etm.2018.6686
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou Y, Xiao L and Tang S: Annexin A2 and FTH1 are potential biomarkers for lupus nephritis. Exp Ther Med 16: 3766-3776, 2018.
APA
Zhou, Y., Xiao, L., & Tang, S. (2018). Annexin A2 and FTH1 are potential biomarkers for lupus nephritis. Experimental and Therapeutic Medicine, 16, 3766-3776. https://doi.org/10.3892/etm.2018.6686
MLA
Zhou, Y., Xiao, L., Tang, S."Annexin A2 and FTH1 are potential biomarkers for lupus nephritis". Experimental and Therapeutic Medicine 16.5 (2018): 3766-3776.
Chicago
Zhou, Y., Xiao, L., Tang, S."Annexin A2 and FTH1 are potential biomarkers for lupus nephritis". Experimental and Therapeutic Medicine 16, no. 5 (2018): 3766-3776. https://doi.org/10.3892/etm.2018.6686
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