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Effects of early intravenous low-dose of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction heart

  • Authors:
    • Dan-Ning Wang
    • Lei Wang
    • Ying Huang
    • Li Hua
    • Hai-Ming Cui
    • Peng-Fei Chen
    • Xin Liang
    • Jia-You Zhang
    • De-Ning Liao
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Shanghai Changzheng Hospital, Shanghai 200433, P.R. China, Department of Cardiology, The 309th Hospital of Chinese People's Liberation Army, Beijing 100193, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4114-4118
    |
    Published online on: September 4, 2018
       https://doi.org/10.3892/etm.2018.6695
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Abstract

This study observed the effects of early intravenous low-doses of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction (MI) dogs. Thirty two mongrel dogs with the first diagonal branch of the left anterior descending coronary artery ligated were randomly divided into three groups: The low-dose group was given metoprolol 0.6 mg/kg immediately by intravenous injection (n=12); the target-dose group was given metoprolol 1.6 mg/kg (n=12), and the control group was injected with normal saline at the same dose of the target-dose group (n=8). Norepinephrine (NE) and epinephrine (E) levels in the coronary sinus (CS) blood as well as the ventricular effective refractory period (ERP) were all measured during the experiments. We found that NE and E concentrations in the three groups were all increased compared with the previous measurement before ligation. ERP values after MI were significantly decreased in all three groups compared with the first measurements. The three groups all exhibited uneven shortness of ERP among different regions, with significant shortness in infarcted area. Furthermore, there was no difference between the low and target-dose of metoprolol in the reduction of regional ERP, and the same effect was also observed in induced arrhythmias. In conclusion, a lower dose of metoprolol performed similarly as target-dose in reducing the catecholamine concentrations in dogs with MI. Our study demonstrated that a lower dose of metoprolol may be reasonable compared with the target-dose in β-blocker therapy due to similar effect and lower toxicity.
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1 

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, et al: American Heart Association Statistics Committee and Stroke Statistics Subcommittee: Heart disease and stroke statistics - 2014 update: A report from the American Heart Association. Circulation. 129:399–410. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Dawber TR, Moore FE and Mann GV: Coronary heart disease in the Framingham study. Am J Public Health Nations Health. 47:4–24. 1957. View Article : Google Scholar : PubMed/NCBI

3 

Sivapalaratnam S, Boekholdt SM, Trip MD, Sandhu MS, Luben R, Kastelein JJ, Wareham NJ and Khaw KT: Family history of premature coronary heart disease and risk prediction in the EPIC-Norfolk prospective population study. Heart. 96:1985–1989. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD and Reid IR: Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: Meta-analysis. BMJ. 341:c36912010. View Article : Google Scholar : PubMed/NCBI

5 

Canto JG, Kiefe CI, Rogers WJ, Peterson ED, Frederick PD, French WJ, Gibson CM, Pollack CV Jr, Ornato JP, Zalenski RJ, et al: NRMI Investigators: Number of coronary heart disease risk factors and mortality in patients with first myocardial infarction. JAMA. 306:2120–2127. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Horne BD, Camp NJ, Muhlestein JB and Cannon-Albright LA: Identification of excess clustering of coronary heart diseases among extended pedigrees in a genealogical population database. Am Heart J. 152:305–311. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Hartiala J, Schwartzman WS, Gabbay J, Ghazalpour A, Bennett BJ and Allayee H: The genetic architecture of coronary artery disease: Current knowledge and future opportunities. Curr Atheroscler Rep. 19:62017. View Article : Google Scholar : PubMed/NCBI

8 

Assmann G, Cullen P and Schulte H: Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Münster (PROCAM) study. Circulation. 105:310–315. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Gyárfás I, Keltai M and Salim Y: Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries in a case-control study based on the INTERHEART study. Orv Hetil. 147:675–686. 2006.(In Hungarian). PubMed/NCBI

10 

Basat O, Ucak S, Seber S, Oztekin E and Altuntas Y: After myocardial infarction carvedilol improves insulin resistance compared to metoprolol. Clin Res Cardiol. 95:99–104. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Tölg R, Witt M, Schwarz B, Kurz T, Kurowski V, Hartmann F, Geist V and Richardt G: Comparison of carvedilol and metoprolol in patients with acute myocardial infarction undergoing primary coronary intervention - the PASSAT Study. Clin Res Cardiol. 95:31–41. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Ilic Deljanin M, Pavlovic RF, Kocic G, Simonovic D and Lazarevic G: Effects of music therapy on endothelial function in patients with coronary artery disease participating in aerobic exercise therapy. Altern Ther Health Med. 23:at54912017.PubMed/NCBI

13 

Cai X, Bao L, Ding Y, Dai X, Zhang Z and Li Y: Quercetin alleviates cell apoptosis and inflammation via the ER stress pathway in vascular endothelial cells cultured in high concentrations of glucosamine. Mol Med Rep. 15:825–832. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Bischoff B, Silber S, Richartz BM, Pieper L, Klotsche J and Wittchen HU: DETECT Study-Group: Inadequate medical treatment of patients with coronary artery disease by primary care physicians in Germany. Clin Res Cardiol. 95:405–412. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Koch KC, Schaefer WM, Liehn EA, Rammos C, Mueller D, Schroeder J, Dimassi T, Stopinski T and Weber C: Effect of catheter-based transendocardial delivery of stromal cell-derived factor 1alpha on left ventricular function and perfusion in a porcine model of myocardial infarction. Basic Res Cardiol. 101:69–77. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Looi KL, Chow KL, Looi JL, Lee M, Halliday S, White H and Ellis C: Under-use of secondary prevention medication in acute coronary syndrome patients treated with in-hospital coronary artery bypass graft surgery. N Z Med J. 124:18–27. 2011.PubMed/NCBI

17 

Costalunga A and Gavazzi A: Effect of carvedilol on outcome after myocardial infarction in patients with left ventricular dysfunction: The CAPRICORN randomized trial. Ital Heart J Suppl. 2:1246–1247. 2001.(In Italian). PubMed/NCBI

18 

Gunnar RM, Bourdillon PD, Dixon DW, Fuster V, Karp RB, Kennedy JW, Klocke FJ, Passamani ER, Pitt B, Rapaport E, et al: ACC/AHA guidelines for the early management of patients with acute myocardial infarction. A report of the American College of Cardiology/American Heart Association Task Force on Assessment of Diagnostic and Therapeutic Cardiovascular Procedures (subcommittee to develop guidelines for the early management of patients with acute myocardial infarction). Circulation. 82:664–707. 1990. View Article : Google Scholar : PubMed/NCBI

19 

Gislason GH, Rasmussen JN, Abildstrøm SZ, Gadsbøll N, Buch P, Friberg J, Rasmussen S, Køber L, Stender S, Madsen M, et al: Long-term compliance with beta-blockers, angiotensin-converting enzyme inhibitors, and statins after acute myocardial infarction. Eur Heart J. 27:1153–1158. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Rochon PA and Gurwitz JH: Prescribing for seniors: Neither too much nor too little. JAMA. 282:113–115. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Ruta J, Ptaszyński P, Maciejewski M, Goch JH and Chizyński K: Effect of low doses of metoprolol, bisoprolol and carvedilol on mortality in patients with left ventricular dysfunction after acute myocardial infarction. Wiad Lek. 59:649–653. 2006.(In Polish). PubMed/NCBI

22 

Grall S, Biere L, Le Nezet M, Bouvier JM, Lucas-Chauvelon P, Richard C, Abi-Khalil W, Delepine S, Prunier F and Furber A: Relationship between beta-blocker and angiotensin-converting enzyme inhibitor dose and clinical outcome following acute myocardial infarction. Circ J. 79:632–640. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Siu CW, Pong V, Jim MH, Yue WS, Ho HH, Li SW, Lau CP and Tse HF: Beta-blocker in post-myocardial infarct survivors with preserved left ventricular systolic function. Pacing Clin Electrophysiol. 33:675–680. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Goldberger JJ, Bonow RO, Cuffe M, Liu L, Rosenberg Y, Shah PK, Smith SC Jr and Subačius H: OBTAIN Investigators: Effect of beta-blocker dose on survival after acute myocardial infarction. J Am Coll Cardiol. 66:1431–1441. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Miyauchi Y, Zhou S, Okuyama Y, Miyauchi M, Hayashi H, Hamabe A, Fishbein MC, Mandel WJ, Chen LS, Chen PS, et al: Altered atrial electrical restitution and heterogeneous sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction: Implications for atrial fibrillation. Circulation. 108:360–366. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang D, Wang L, Huang Y, Hua L, Cui H, Chen P, Liang X, Zhang J and Liao D: Effects of early intravenous low-dose of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction heart. Exp Ther Med 16: 4114-4118, 2018.
APA
Wang, D., Wang, L., Huang, Y., Hua, L., Cui, H., Chen, P. ... Liao, D. (2018). Effects of early intravenous low-dose of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction heart. Experimental and Therapeutic Medicine, 16, 4114-4118. https://doi.org/10.3892/etm.2018.6695
MLA
Wang, D., Wang, L., Huang, Y., Hua, L., Cui, H., Chen, P., Liang, X., Zhang, J., Liao, D."Effects of early intravenous low-dose of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction heart". Experimental and Therapeutic Medicine 16.5 (2018): 4114-4118.
Chicago
Wang, D., Wang, L., Huang, Y., Hua, L., Cui, H., Chen, P., Liang, X., Zhang, J., Liao, D."Effects of early intravenous low-dose of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction heart". Experimental and Therapeutic Medicine 16, no. 5 (2018): 4114-4118. https://doi.org/10.3892/etm.2018.6695
Copy and paste a formatted citation
x
Spandidos Publications style
Wang D, Wang L, Huang Y, Hua L, Cui H, Chen P, Liang X, Zhang J and Liao D: Effects of early intravenous low-dose of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction heart. Exp Ther Med 16: 4114-4118, 2018.
APA
Wang, D., Wang, L., Huang, Y., Hua, L., Cui, H., Chen, P. ... Liao, D. (2018). Effects of early intravenous low-dose of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction heart. Experimental and Therapeutic Medicine, 16, 4114-4118. https://doi.org/10.3892/etm.2018.6695
MLA
Wang, D., Wang, L., Huang, Y., Hua, L., Cui, H., Chen, P., Liang, X., Zhang, J., Liao, D."Effects of early intravenous low-dose of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction heart". Experimental and Therapeutic Medicine 16.5 (2018): 4114-4118.
Chicago
Wang, D., Wang, L., Huang, Y., Hua, L., Cui, H., Chen, P., Liang, X., Zhang, J., Liao, D."Effects of early intravenous low-dose of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction heart". Experimental and Therapeutic Medicine 16, no. 5 (2018): 4114-4118. https://doi.org/10.3892/etm.2018.6695
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