Open Access

Eupatilin inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage

  • Authors:
    • Hai‑Bo Qiao
    • Jia Li
    • Lian‑Jie Lv
    • Ben‑Jin Nie
    • Peng Lu
    • Feng Xue
    • Zhi‑Ming Zhang
  • View Affiliations

  • Published online on: September 5, 2018     https://doi.org/10.3892/etm.2018.6699
  • Pages: 4005-4009
  • Copyright: © Qiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Inflammation serves a critical role in the pathophysiology of intracerebral hemorrhage (ICH)‑induced brain injury. Eupatilin, a pharmacologically active flavone derived from Artemisia sp., has been reported to have antioxidant, anti‑inflammatory, anti‑allergic and antitumor activities. However, the effect of eupatilin in ICH has not been well studied. The aim of the present study was to investigate the effect of eupatilin on ICH‑induced microglial inflammation. The MTT and Transwell migration assay results revealed that eupatilin significantly inhibited microglial migration. It also decreased the production of inflammatory cytokines in erythrocyte lysis‑induced BV2 cells, as well as the level of intracellular reactive oxygen species. The anti‑inflammatory mechanism of eupatilin was also investigated using ELISAs and western blotting and the results demonstrated that eupatilin was able to inhibit erythrocyte lysis‑induced NF‑κB activation in BV2 cells. Taken together, the results of the present study suggest that eupatilin serves neurological protective effects via inhibiting microglial inflammation, providing an experimental basis for the use of eupatilin as a therapeutic target for ICH.
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November-2018
Volume 16 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Qiao HB, Li J, Lv LJ, Nie BJ, Lu P, Xue F and Zhang ZM: Eupatilin inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage. Exp Ther Med 16: 4005-4009, 2018.
APA
Qiao, H., Li, J., Lv, L., Nie, B., Lu, P., Xue, F., & Zhang, Z. (2018). Eupatilin inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage. Experimental and Therapeutic Medicine, 16, 4005-4009. https://doi.org/10.3892/etm.2018.6699
MLA
Qiao, H., Li, J., Lv, L., Nie, B., Lu, P., Xue, F., Zhang, Z."Eupatilin inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage". Experimental and Therapeutic Medicine 16.5 (2018): 4005-4009.
Chicago
Qiao, H., Li, J., Lv, L., Nie, B., Lu, P., Xue, F., Zhang, Z."Eupatilin inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage". Experimental and Therapeutic Medicine 16, no. 5 (2018): 4005-4009. https://doi.org/10.3892/etm.2018.6699