Open Access

Immunomodulatory effect of Bifidobacterium breve on experimental allergic rhinitis in BALB/c mice

  • Authors:
    • Jianjun Ren
    • Yu Zhao
    • Shi Huang
    • Dan Lv
    • Fengling Yang
    • Lin Lou
    • Yongbo Zheng
    • Jie Zhang
    • Shixi Liu
    • Nan Zhang
    • Claus Bachert
  • View Affiliations

  • Published online on: September 6, 2018     https://doi.org/10.3892/etm.2018.6704
  • Pages: 3996-4004
  • Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bifidobacterium breve (B. breve) may have a beneficial effect on allergic rhinitis (AR). The aim of the present study was to investigate whether microbial induction of regulatory T cells (Tregs) and adjustment of Th1 and Th2 responses by B. breve are associated with protection against allergic inflammation, and to identify a dose‑response association in a murine AR model. Ovalbumin (OVA)‑sensitized BALB/c mice were orally treated with different doses of B. breve [1010, 109, 107 and 105 colony forming units (CFU)]. Following nasal challenge with OVA, sneeze frequency, serum OVA‑specific immunoglobulin E (IgE) and cytokine concentrations [interleukin (IL)‑4, IL‑10, IL‑13 and interferon‑γ], splenic percentage of cluster of differentiation (CD)4+CD25+ Tregs, and morphology of the nasal mucosa were examined. Oral treatment with live B. breve at doses of 107 CFU or higher alleviated nasal mucosal injury and suppressed sneezing upon repeated administration over a 6‑week period. Furthermore, treatment with B. breve at these higher doses reduced the concentrations of serum OVA‑specific IgE, IL‑4 and IL‑10, and increased the splenic percentage of CD4+CD25+ Tregs in rhinitic mice compared with those who did not receive probiotics. In contrast, treatment with B. breve at a lower dose did not indicate any effect on sneezing frequency or mucosal morphology in this animal model, even though the splenic percentage of CD4+CD25+ Tregs increased and the concentrations of serum OVA‑specific IgE and IL‑10 declined. B. breve exerts its anti‑allergic effects by inhibiting type 2 helper T cell immune responses and enhancing CD4+CD25+ Treg activity. Sneezing was also reduced at a dose of 107 CFU or higher. The current study investigated the role of B. breve and aided in identifying the optimal dose of B. breve administration in the treatment of AR.
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November-2018
Volume 16 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ren J, Zhao Y, Huang S, Lv D, Yang F, Lou L, Zheng Y, Zhang J, Liu S, Zhang N, Zhang N, et al: Immunomodulatory effect of Bifidobacterium breve on experimental allergic rhinitis in BALB/c mice. Exp Ther Med 16: 3996-4004, 2018
APA
Ren, J., Zhao, Y., Huang, S., Lv, D., Yang, F., Lou, L. ... Bachert, C. (2018). Immunomodulatory effect of Bifidobacterium breve on experimental allergic rhinitis in BALB/c mice. Experimental and Therapeutic Medicine, 16, 3996-4004. https://doi.org/10.3892/etm.2018.6704
MLA
Ren, J., Zhao, Y., Huang, S., Lv, D., Yang, F., Lou, L., Zheng, Y., Zhang, J., Liu, S., Zhang, N., Bachert, C."Immunomodulatory effect of Bifidobacterium breve on experimental allergic rhinitis in BALB/c mice". Experimental and Therapeutic Medicine 16.5 (2018): 3996-4004.
Chicago
Ren, J., Zhao, Y., Huang, S., Lv, D., Yang, F., Lou, L., Zheng, Y., Zhang, J., Liu, S., Zhang, N., Bachert, C."Immunomodulatory effect of Bifidobacterium breve on experimental allergic rhinitis in BALB/c mice". Experimental and Therapeutic Medicine 16, no. 5 (2018): 3996-4004. https://doi.org/10.3892/etm.2018.6704