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Article

Early predictors of hyperlipidemic acute pancreatitis

  • Authors:
    • Xi Cao
    • Huai‑Ming Wang
    • Hai Du
    • Er‑Xia Chen
    • Xiu‑Feng Yang
    • Shi‑Long Wang
    • Ya Ding
    • Zhan‑Fei She
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Ordos Central Hospital, Ordos, Inner Mongolia 017000, P.R. China, CT‑MRI Room, Ordos Central Hospital, Ordos, Inner Mongolia 017000, P.R. China
  • Pages: 4232-4238
    |
    Published online on: September 10, 2018
       https://doi.org/10.3892/etm.2018.6713
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Abstract

The present study aimed to investigate early risk factors for hyperlipidemic acute pancreatitis (HLAP) in order to open up novel routes for its prevention and treatment. Demographics, laboratory data obtained within 48 h, enhanced computed tomography (CT) imaging data and the modified CT severity index (MCTSI) for 111 patients with HLAP who were assessed at Ordos Central Hospital (Ordos, China) between January 2015 and October 2017 were retrospectively analyzed. Of these, 17 patients progressed to infectious pancreatic necrosis (IPN) and 14 patients progressed to organ failure (OF), the occurrence of which were the study outcomes. The patients were divided into pairs groups: IPN and non‑IPN, as well as OF and non‑OF, and differences between the groups were determined regarding various clinicopathological parameters. Furthermore, univariate and multivariate regression analyses were performed to identify parameters associated with the risk of progression to IPN or OP. On univariate analysis, the following parameters were deemed as being significantly associated with the risk of IPN: Serum calcium ions, C‑reactive protein (CRP), extent of necrosis, procalcitonin (PTC) and the MCTSI. Furthermore, calcium ions, red cell distribution width (RDW), extent of necrosis and the MCTSI were significantly associated with the risk of OF on univariate analysis. Multivariate logistic regression analysis for these parameters then indicated that CRP (P=0.014), RDW (P=0.025) and the extent of necrosis (P=0.022) were significant and independent predictors of progression; thus, these are early risk factors for patients with HLAP. Receiver operating characteristic curves were generated to evaluate the predictive value of these factors, and the area under the curve for the three parameters was 0.863 [95% confidence interval (CI), 0.646‑0.886], 0.727 (95% CI, 0.651‑0.803) and 0.833 (95% CI, 0.739‑0.936), respectively. Therefore, CRP, RDW and the extent of necrosis are early predictive indexes for the risk of progression in HLAP.
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Copy and paste a formatted citation
Spandidos Publications style
Cao X, Wang HM, Du H, Chen EX, Yang XF, Wang SL, Ding Y and She ZF: Early predictors of hyperlipidemic acute pancreatitis. Exp Ther Med 16: 4232-4238, 2018.
APA
Cao, X., Wang, H., Du, H., Chen, E., Yang, X., Wang, S. ... She, Z. (2018). Early predictors of hyperlipidemic acute pancreatitis. Experimental and Therapeutic Medicine, 16, 4232-4238. https://doi.org/10.3892/etm.2018.6713
MLA
Cao, X., Wang, H., Du, H., Chen, E., Yang, X., Wang, S., Ding, Y., She, Z."Early predictors of hyperlipidemic acute pancreatitis". Experimental and Therapeutic Medicine 16.5 (2018): 4232-4238.
Chicago
Cao, X., Wang, H., Du, H., Chen, E., Yang, X., Wang, S., Ding, Y., She, Z."Early predictors of hyperlipidemic acute pancreatitis". Experimental and Therapeutic Medicine 16, no. 5 (2018): 4232-4238. https://doi.org/10.3892/etm.2018.6713
Copy and paste a formatted citation
x
Spandidos Publications style
Cao X, Wang HM, Du H, Chen EX, Yang XF, Wang SL, Ding Y and She ZF: Early predictors of hyperlipidemic acute pancreatitis. Exp Ther Med 16: 4232-4238, 2018.
APA
Cao, X., Wang, H., Du, H., Chen, E., Yang, X., Wang, S. ... She, Z. (2018). Early predictors of hyperlipidemic acute pancreatitis. Experimental and Therapeutic Medicine, 16, 4232-4238. https://doi.org/10.3892/etm.2018.6713
MLA
Cao, X., Wang, H., Du, H., Chen, E., Yang, X., Wang, S., Ding, Y., She, Z."Early predictors of hyperlipidemic acute pancreatitis". Experimental and Therapeutic Medicine 16.5 (2018): 4232-4238.
Chicago
Cao, X., Wang, H., Du, H., Chen, E., Yang, X., Wang, S., Ding, Y., She, Z."Early predictors of hyperlipidemic acute pancreatitis". Experimental and Therapeutic Medicine 16, no. 5 (2018): 4232-4238. https://doi.org/10.3892/etm.2018.6713
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