Electrocardiography‑gated dual‑source computed tomography in the detection of atrial septal aneurysm

Xie,Lixiang; Liu,Zhongxiao; Zhang,Xiuli; Xu,Kai; Xu,Qian; Lu,Li; Hu,Chunfeng; Han,Shuguang; Li,Jingjing

doi:10.3892/etm.2018.6717

November-2018 Volume 16 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

November-2018 Volume 16 Issue 5

Full Size Image

Article

Electrocardiography‑gated dual‑source computed tomography in the detection of atrial septal aneurysm

Authors:
- Lixiang Xie
- Zhongxiao Liu
- Xiuli Zhang
- Kai Xu
- Qian Xu
- Li Lu
- Chunfeng Hu
- Shuguang Han
- Jingjing Li
View Affiliations / Copyright

Affiliations: Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China
Pages: 4260-4264
|
Published online on: September 11, 2018

https://doi.org/10.3892/etm.2018.6717
Expand metrics +

Abstract

The aim of the current study was to investigate the atrial septal aneurysm (ASA) incidence rate and describe its morphologic features by dual‑source computed tomography (DSCT). A total of 8,626 patients (4,284 men and 4,342 women) who underwent DSCT examinations were enrolled. The presence of ASA was defined as the protrusion of the complete or partial interatrial septum with a maximum vertical distance (MVD) from the atrial septum plane of >10 mm during a cardiac cycle and a diameter of the aneurysm base of >15 mm. The MVD and direction of the protrusion, as well as other abnormalities, were recorded. The ASA patients were classified by both gender and directions of protrusion into four groups, including the right atrium (RA) and left atrium (LA) groups in males and females, respectively. Values across groups were compared using the independent‑sample t‑test and differences in qualitative variables were assessed with the χ2 test. Of the 8,626 patients, 51 (0.6%) were diagnosed with ASA (mean age, 62±10 years), including 23 (0.5%) males and 28 (0.6%) females. There were no significant differences in the age (t=‑1.37, P>0.05) and incidence rate (χ2=0.43, P>0.05) between the male and female groups. However, there were significant differences in the mean ages (t=‑2.20, P<0.05) and the gender proportions (χ2=7.39, P<0.05) of patients in the RA and LA groups. In the two male groups, no significant differences were observed in the diameters of the ASA bases and MVD in the RA and LA groups. In the female groups, the differences in the MVD of protrusion in RA and LA groups were non‑significant, whereas the diameters of the base of ASA demonstrated significant differences (t=2.27, P<0.05). In conclusion, the ASA incidence rate was 0.6%, and electrocardiography‑gated DSCT scan served as an alternative diagnostic technique for the detection of ASA. It is essential for radiologists to recognize this clinical entity and to minimize misdiagnoses and missed diagnoses.

View Figures

View References

1	Janion M and Kurzawski J: Atrial fibrillation in patients with atrial septal aneurysm. Cardiol J. 14:580–584. 2007.PubMed/NCBI
2	Madan V, Harkness K, Brien EO and Warburton EA: Lone atrial septal aneurysm and stroke-a case report and review of the literature. Eur J Intern Med. 16:520–522. 2005. View Article : Google Scholar : PubMed/NCBI
3	Czekajska-Chehab E, Tomaszewski A, Tomaszewska M, Siek E, Uhlig S and Drop A: ECG-gated multi-slice computed tomography in the detection of atrial septal aneurysms. Folia Morphol (Warsz. ). 67:126–128. 2008.PubMed/NCBI
4	Mugge A, Daniel WG, Angermann C, Spes C, Khandheria BK, Kronzon I, Freedberg RS, Keren A, Denning K and Engberding R: Atrial septal aneurysm in adult patients. A multicenter study using transthoracic and transesophageal echocardiography. Circulation. 91:2785–2792. 1995. View Article : Google Scholar : PubMed/NCBI
5	Giannopoulos A, Gavras C, Sarioglou S, Agathagelou F, Kassapoglou I and Athanassiadou F: Atrial septal aneurysms in childhood: Prevalence, classification, and concurrent abnormalities. Cardiol Young. 24:453–458. 2014. View Article : Google Scholar : PubMed/NCBI
6	Achenbach S and Kondo T: Technical advances in cardiac CT. Cardiol Clin. 30:1–8. 2012. View Article : Google Scholar : PubMed/NCBI
7	Zeina AR, Orlov I, Sharif D and Barmeir E: Detection of atrial septal aneurysm by ECG-gated MDCT. AJR Am J Roentgenol. 187:W229–W230. 2006. View Article : Google Scholar : PubMed/NCBI
8	Dodd JD, Aquino SL, Holmvang G, Cury RC, Hoffmann U, Brady TJ and Abbara S: Cardiac septal aneurysm mimicking pseudomass: Appearance on ECG-gated cardiac MRI and MDCT. AJR Am J Roentgenol. 188:W550–W553. 2007. View Article : Google Scholar : PubMed/NCBI
9	Demir M: The relationship between atrial septal aneurysm and autonomic dysfunction. Exp Clin Cardiol. 18:104–106. 2013.PubMed/NCBI
10	Oyedeji AT, Okunola O and Sani Umar M: Atrial septal aneurysm mimicking a cor triatriatum sinister: A case report and review of the literature. Clin Med Insights Case Rep. 5:143–147. 2012. View Article : Google Scholar : PubMed/NCBI
11	Homma S and Sacco RL: Patent foramen ovale and stroke. Circulation. 112:1063–1072. 2005. View Article : Google Scholar : PubMed/NCBI
12	Carerj S, Narbone MC, Zito C, Serra S, Coglitore S, Pugliatti P, Luzza F, Arrigo F and Oreto G: Prevalence of atrial septal aneurysm in patients with migraine: An echocardiographic study. Headache. 43:725–728. 2003. View Article : Google Scholar : PubMed/NCBI
13	Mattioli AV, Aquilina M, Oldani A, Longhini C and Mattioli G: Atrial septal aneurysm as a cardioembolic source in adult patients with stroke and normal carotid arteries. A multicentre study. Eur Heart J. 22:261–268. 2001. View Article : Google Scholar : PubMed/NCBI
14	Kurzawski J, Janion M and Sielski J: Does the morphology of atrial septal aneurysm influence cerebral arterial embolus occurrence? Echocardiography. 24:895–900. 2007. View Article : Google Scholar : PubMed/NCBI
15	Overell JR, Bone I and Lees KR: Interatrial septal abnormalities and stroke: A meta-analysis of case-control studies. Neurology. 55:1172–1179. 2000. View Article : Google Scholar : PubMed/NCBI
16	Messe SR, Silverman IE, Kizer JR, Homma S, Zahn C, Gronseth G and Kasner SE; Quality StandardsSubcommittee of the American Academy of Neurology, : Practice parameter: Recurrent stroke with patent foramen ovale and atrial septal aneurysm: Report of the quality standards subcommittee of the american academy of neurology. Neurology. 62:1042–1050. 2004. View Article : Google Scholar : PubMed/NCBI
17	Mas JL, Arquizan C, Lamy C, Zuber M, Cabanes L, Derumeaux G and Coste J; Patent Foramen Ovale and Atrial Septal Aneurysm Study Group, : Recurrent cerebrovascular events associated with patent foramen ovale, atrial septal aneurysm, or both. N Engl J Med. 345:1740–1746. 2001. View Article : Google Scholar : PubMed/NCBI
18	Koplay M, Cimen D, Sivri M, Güvenc O, Arslan D, Nayman A and Oran B: Truncus arteriosus: Diagnosis with dual-source computed tomography angiography and low radiation dose. World J Radiol. 6:886–889. 2014. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Electrocardiography‑gated dual‑source computed tomography in the detection of atrial septal aneurysm

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles