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Expression of somatostatin and its receptor 1‑5 in endometriotic tissues and cells

  • Authors:
    • Yanhua Zhao
    • Lin Peng
    • Xiang Li
    • Yi Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China , Reproductive and Stem Cell Research Institute, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China, Department of Pathology, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3777-3784
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    Published online on: September 12, 2018
       https://doi.org/10.3892/etm.2018.6730
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Abstract

The present study aimed to detect the expression of somatostatin (SS) and SS receptor (SSTR)1‑5 in tissues from patients with endometriosis (EMS). Reverse transcription‑quantitative polymerase chain reaction analysis was applied to examine the expression of somatostatin gene in ectopic endometrial cells (EECs). The expression of somatostatin receptor 1‑5 in the ectopic endometrium (EE), eutopic endometrium and normal endometrium and their association with EMS staging were determined by immunohistochemistry. The results indicated that the expression of SS in EECs was significantly higher compared with that in the control group. SSTR1‑5 were expressed in the EE tissues from 30 patients with EMS, and the positive rates were 43.3, 70.0, 53.3, 50.0 and 96.7%, respectively, which were closely associated with EMS staging of the patients. The positive rates of SSTR1‑5 expression in the eutopic endometrium from 12 patients with EMS were 33.3, 41.7, 58.3, 58.3 and 83.3%, respectively, while the positive rates of SSTR1‑5 expression in the normal endometrium from 14 women without EMS were 7.1, 7.1, 21.4, 28.6 and 64.3%, which were lower than the positive rates of SSTR1‑5 in the EE (43.3, 70, 53.3, 50 and 96.7%) and eutopic endometrial cells (33.3, 41.7, 58.3, 58.3 and 83.3%). In conclusion, SS was highly expressed in EECs. SSTR1‑5 were expressed in the ectopic as well as eutopic endometrium, and low or moderate expression of SSTR1‑4 and high expression of SSTR5 were detected in the ectopic and eutopic endometrial tissues, while low expression of SSTR1‑4 and partial expression of SSTR5 were detected in normal endometrium. The positive rates of expression of SSTR1‑5 in the EE cells and eutopic endometrium were higher than those in the normal endometrium. The expression of all the subtypes of SSTR in the EE tissues was closely associated with EMS staging.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Peng L, Li X and Zhang Y: Expression of somatostatin and its receptor 1‑5 in endometriotic tissues and cells. Exp Ther Med 16: 3777-3784, 2018.
APA
Zhao, Y., Peng, L., Li, X., & Zhang, Y. (2018). Expression of somatostatin and its receptor 1‑5 in endometriotic tissues and cells. Experimental and Therapeutic Medicine, 16, 3777-3784. https://doi.org/10.3892/etm.2018.6730
MLA
Zhao, Y., Peng, L., Li, X., Zhang, Y."Expression of somatostatin and its receptor 1‑5 in endometriotic tissues and cells". Experimental and Therapeutic Medicine 16.5 (2018): 3777-3784.
Chicago
Zhao, Y., Peng, L., Li, X., Zhang, Y."Expression of somatostatin and its receptor 1‑5 in endometriotic tissues and cells". Experimental and Therapeutic Medicine 16, no. 5 (2018): 3777-3784. https://doi.org/10.3892/etm.2018.6730
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Peng L, Li X and Zhang Y: Expression of somatostatin and its receptor 1‑5 in endometriotic tissues and cells. Exp Ther Med 16: 3777-3784, 2018.
APA
Zhao, Y., Peng, L., Li, X., & Zhang, Y. (2018). Expression of somatostatin and its receptor 1‑5 in endometriotic tissues and cells. Experimental and Therapeutic Medicine, 16, 3777-3784. https://doi.org/10.3892/etm.2018.6730
MLA
Zhao, Y., Peng, L., Li, X., Zhang, Y."Expression of somatostatin and its receptor 1‑5 in endometriotic tissues and cells". Experimental and Therapeutic Medicine 16.5 (2018): 3777-3784.
Chicago
Zhao, Y., Peng, L., Li, X., Zhang, Y."Expression of somatostatin and its receptor 1‑5 in endometriotic tissues and cells". Experimental and Therapeutic Medicine 16, no. 5 (2018): 3777-3784. https://doi.org/10.3892/etm.2018.6730
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