Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2019 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2019 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Biological therapies for atopic dermatitis: An update (Review)

  • Authors:
    • Diana Deleanu
    • Irena Nedelea
  • View Affiliations / Copyright

    Affiliations: Allergology and Immunology Discipline, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400058 Cluj-Napoca, Romania
  • Pages: 1061-1067
    |
    Published online on: November 19, 2018
       https://doi.org/10.3892/etm.2018.6989
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Severe atopic dermatitis, which affects both adults and children, is a debilitating disorder with a significant decline of patients' quality of life. Although aetiopathogenic factors are currently a topic of study and interpretation, the main features of atopic eczema are skin barrier disturbance and immune dysregulation. Severe refractory disease that fails to improve with conventional therapy may benefit from biologic therapy. Progress in understanding immunopathology of atopic dermatitis have allowed identification of therapeutic molecular targets in the field of biological therapy. We reviewed the different biological treatments with a focus on novel targeted agents: Systemic immunotherapy (Omalizumab, Dupilumab, Lebrikizumab, Tralokinumab, Nemolizumab, Ustekinumab, Fezakinumab, Tezepelumab, Apremilast, allergen specific immunotherapy), and topical agents (Tofacitinib, Crisaborole).
View Figures
View References

1 

Barbarot S, Auziere S, Gadkari A, Girolomoni G, Puig L, Simpson EL, Margolis DJ, de Bruin-Weller M and Eckert L: Epidemiology of atopic dermatitis in adults: Results from an international survey. Allergy. 73:1284–1293. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK and Williams H: ISAAC Phase Three Study Group: Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 368:733–743. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Nutten S: Atopic dermatitis: Global epidemiology and risk factors. Ann Nutr Metab. 66 Suppl 1:8–16. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Dharmage SC, Lowe AJ, Matheson MC, Burgess JA, Allen KJ and Abramson MJ: Atopic dermatitis and the atopic march revisited. Allergy. 69:17–27. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Mortz CG, Andersen KE, Dellgren C, Barington T and Bindslev-Jensen C: Atopic dermatitis from adolescence to adulthood in the TOACS cohort: Prevalence, persistence and comorbidities. Allergy. 70:836–845. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Constantin MM: Value and impact of patch testing in patients with allergic contact dermatitis. Rom J Lab Med. 20:101–106. 2012.

7 

Montes-Torres A, Llamas-Velasco M, Pérez-Plaza A, Solano-López G and Sánchez-Pérez J: Biological Treatments in Atopic Dermatitis. J Clin Med. 4:593–613. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Milgrom H, Fick RB Jr, Su JQ, Reimann JD, Bush RK, Watrous ML and Metzger WJ: Treatment of allergic asthma with monoclonal anti-IgE antibody. rhuMAb-E25 Study Group. N Engl J Med. 341:1966–1973. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Salvi SS and Babu KS: Treatment of allergic asthma with monoclonal anti-IgE antibody. N Engl J Med. 342:1292–1293. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Wu KC and Jabbar-Lopez ZK: Omalizumab, an Anti-IgE mAb, receives approval for the treatment of chronic idiopathic/spontaneous urticaria. J Invest Dermatol. 135:13–15. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Magerl M, Altrichter S, Borzova E, Giménez-Arnau A, Grattan CE, Lawlor F, Mathelier-Fusade P, Meshkova RY, Zuberbier T, Metz M, et al: The definition, diagnostic testing, and management of chronic inducible urticarias - The EAACI/GA(2) LEN/EDF/UNEV consensus recommendations 2016 update and revision. Allergy. 71:780–802. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Vashisht P and Casale T: Omalizumab for treatment of allergic rhinitis. Expert Opin Biol Ther. 13:933–945. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Loizou D, Enav B, Komlodi-Pasztor E, Hider P, Kim-Chang J, Noonan L, Taber T, Kaushal S, Limgala R, Brown M, et al: A pilot study of omalizumab in eosinophilic esophagitis. PLoS One. 10:e01134832015. View Article : Google Scholar : PubMed/NCBI

14 

Lieberman JA and Chehade M: Use of omalizumab in the treatment of food allergy and anaphylaxis. Curr Allergy Asthma Rep. 13:78–84. 2013. View Article : Google Scholar : PubMed/NCBI

15 

El-Qutob D: Off-label uses of omalizumab. Clin Rev Allergy Immunol. 50:84–96. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Wright JD, Chu HM, Huang CH, Ma C, Chang TW and Lim C: Structural and physical basis for anti-IgE therapy. Sci Rep. 5:115812015. View Article : Google Scholar : PubMed/NCBI

17 

Liu J, Lester P, Builder S and Shire SJ: Characterization of complex formation by humanized anti-IgE monoclonal antibody and monoclonal human IgE. Biochemistry. 34:10474–10482. 1995. View Article : Google Scholar : PubMed/NCBI

18 

Brownell J and Casale TB: Anti-IgE therapy. Immunol Allergy Clin North Am. 24:551–568. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Sallmann E, Reininger B, Brandt S, Duschek N, Hoflehner E, Garner-Spitzer E, Platzer B, Dehlink E, Hammer M, Holcmann M, et al: High-affinity IgE receptors on dendritic cells exacerbate Th2-dependent inflammation. J Immunol. 187:164–171. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Rissoan MC, Soumelis V, Kadowaki N, Grouard G, Briere F, de Waal Malefyt R and Liu YJ: Reciprocal control of T helper cell and dendritic cell differentiation. Science. 283:1183–1186. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Noga O, Hanf G and Kunkel G: Immunological and clinical changes in allergic asthmatics following treatment with omalizumab. Int Arch Allergy Immunol. 131:46–52. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Kitaura J, Song J, Tsai M, Asai K, Maeda-Yamamoto M, Mocsai A, Kawakami Y, Liu FT, Lowell CA, Barisas BG, et al: Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI. Proc Natl Acad Sci USA. 100:12911–12916. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Noga O, Hanf G, Brachmann I, Klucken AC, Kleine-Tebbe J, Rosseau S, Kunkel G, Suttorp N and Seybold J: Effect of omalizumab treatment on peripheral eosinophil and T-lymphocyte function in patients with allergic asthma. J Allergy Clin Immunol. 117:1493–1499. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Lane JE, Cheyney JM, Lane TN, Kent DE and Cohen DJ: Treatment of recalcitrant atopic dermatitis with omalizumab. J Am Acad Dermatol. 54:68–72. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Thaiwat S and Sangasapaviliya A: Omalizumab treatment in severe adult atopic dermatitis. Asian Pac J Allergy Immunol. 29:357–360. 2011.PubMed/NCBI

26 

Fernández-Antón Martínez MC, Leis-Dosil V, Alfageme-Roldán F, Paravisini A, Sánchez-Ramón S and Suárez Fernández R: Omalizumab for the treatment of atopic dermatitis. Actas Dermosifiliogr. 103:624–628. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Iyengar SR, Hoyte EG, Loza A, Bonaccorso S, Chiang D, Umetsu DT and Nadeau KC: Immunologic effects of omalizumab in children with severe refractory atopic dermatitis: A randomized, placebo-controlled clinical trial. Int Arch Allergy Immunol. 162:89–93. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Velling P, Skowasch D, Pabst S, Jansen E, Tuleta I and Grohé C: Improvement of quality of life in patients with concomitant allergic asthma and atopic dermatitis: One year follow-up of omalizumab therapy. Eur J Med Res. 16:407–410. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Kim DH, Park KY, Kim BJ, Kim MN and Mun SK: Anti-immunoglobulin E in the treatment of refractory atopic dermatitis. Clin Exp Dermatol. 38:496–500. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Romano C, Sellitto A, De Fanis U, Balestrieri A, Savoia A, Abbadessa S, Astarita C and Lucivero G: Omalizumab for difficult-to-treat dermatological conditions: Clinical and immunological features from a retrospective real-life experience. Clin Drug Investig. 35:159–168. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Vigo PG, Girgis KR, Pfuetze BL, Critchlow ME, Fisher J and Hussain I: Efficacy of anti-IgE therapy in patients with atopic dermatitis. J Am Acad Dermatol. 55:168–170. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Heil PM, Maurer D, Klein B, Hultsch T and Stingl G: Omalizumab therapy in atopic dermatitis: Depletion of IgE does not improve the clinical course - a randomized, placebo-controlled and double blind pilot study. J Dtsch Dermatol Ges. 8:990–998. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Krathen RA and Hsu S: Failure of omalizumab for treatment of severe adult atopic dermatitis. J Am Acad Dermatol. 53:338–340. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Wang HH, Li YC and Huang YC: Efficacy of omalizumab in patients with atopic dermatitis: A systematic review and meta-analysis. J Allergy Clin Immunol. 138:1719–1722. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Hotze M, Baurecht H, Rodríguez E, Chapman-Rothe N, Ollert M, Fölster-Holst R, Adamski J, Illig T, Ring J and Weidinger S: Increased efficacy of omalizumab in atopic dermatitis patients with wild-type filaggrin status and higher serum levels of phosphatidylcholines. Allergy. 69:132–135. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Andreae DA and Wang J: Immunologic effects of omalizumab in children with severe refractory atopic dermatitis: A randomized, placebo-controlled clinical trial. Pediatrics. 134 Suppl 3:S1602014. View Article : Google Scholar : PubMed/NCBI

37 

Shirley M: Dupilumab: First global approval. Drugs. 77:1115–1121. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Hamilton JD, Ungar B and Guttman-Yassky E: Drug evaluation review: Dupilumab in atopic dermatitis. Immunotherapy. 7:1043–1058. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Vella A, Teague TK, Ihle J, Kappler J and Marrack P: Interleukin-4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4. J Exp Med. 186:325–330. 1997. View Article : Google Scholar : PubMed/NCBI

40 

Enelow R, Baramki DF and Borish LC: Inhibition of effector T lymphocytes mediated through antagonism of IL-4. J Allergy Clin Immunol. 113:560–562. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Schleimer RP, Sterbinsky SA, Kaiser J, Bickel CA, Klunk DA, Tomioka K, Newman W, Luscinskas FW, Gimbrone MA Jr, McIntyre BW, et al: IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1. J Immunol. 148:1086–1092. 1992.PubMed/NCBI

42 

Tanaka T, Hitomi Y, Kambayashi Y, Hibino Y, Fukutomi Y, Shibata A, Sugimoto N, Hatta K, Eboshida A, Konoshita T, et al: The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor A chain gene between atopic dermatitis and Japanese cedar pollinosis. Allergol Int. 61:57–63. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Hackstein H, Hecker M, Kruse S, Bohnert A, Ober C, Deichmann KA and Bein G: A novel polymorphism in the 5 promoter region of the human interleukin-4 receptor alpha-chain gene is associated with decreased soluble interleukin-4 receptor protein levels. Immunogenetics. 53:264–269. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Hershey GK, Friedrich MF, Esswein LA, Thomas ML and Chatila TA: The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Engl J Med. 337:1720–1725. 1997. View Article : Google Scholar : PubMed/NCBI

45 

Tamura K, Suzuki M, Arakawa H, Tokuyama K and Morikawa A: Linkage and association studies of STAT6 gene polymorphisms and allergic diseases. Int Arch Allergy Immunol. 131:33–38. 2003. View Article : Google Scholar : PubMed/NCBI

46 

Howell MD, Fairchild HR, Kim BE, Bin L, Boguniewicz M, Redzic JS, Hansen KC and Leung DY: Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation. J Invest Dermatol. 128:2248–2258. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Howell MD, Kim BE, Gao P, Grant AV, Boguniewicz M, Debenedetto A, Schneider L, Beck LA, Barnes KC and Leung DY: Cytokine modulation of atopic dermatitis filaggrin skin expression. J Allergy Clin Immunol. 120:150–155. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Kim BE, Leung DY, Boguniewicz M and Howell MD: Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6. Clin Immunol. 126:332–337. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Hsieh FH, Lam BK, Penrose JF, Austen KF and Boyce JA: T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: Profound induction of leukotriene C(4) synthase expression by interleukin 4. J Exp Med. 193:123–133. 2001. View Article : Google Scholar : PubMed/NCBI

50 

Beck LA, Thaçi D, Hamilton JD, Graham NM, Bieber T, Rocklin R, Ming JE, Ren H, Kao R, Simpson E, et al: Dupilumab treatment in adults with moderate-to-severe atopic dermatitis. N Engl J Med. 371:130–139. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Hamilton JD, Suárez-Fariñas M, Dhingra N, Cardinale I, Li X, Kostic A, Ming JE, Radin AR, Krueger JG, Graham N, et al: Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis. J Allergy Clin Immunol. 134:1293–1300. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Blakely K, Gooderham M and Papp K: Dupilumab, a monoclonal antibody for atopic dermatitis: A review of current literature. Skin Therapy Lett. 21:1–5. 2016.PubMed/NCBI

53 

Thaçi D, Simpson EL, Beck LA, Bieber T, Blauvelt A, Papp K, Soong W, Worm M, Szepietowski JC, Sofen H, et al: Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: A randomised, placebo-controlled, dose-ranging phase 2b trial. Lancet. 387:40–52. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Tsianakas A, Luger TA and Radin A: Dupilumab treatment improves quality of life in adult patients with moderate-to-severe atopic dermatitis: Results from a randomized, placebo-controlled clinical trial. Br J Dermatol. 178:406–414. 2018. View Article : Google Scholar : PubMed/NCBI

55 

Simpson EL, Bieber T, Guttman-Yassky E, Beck LA, Blauvelt A, Cork MJ, Silverberg JI, Deleuran M, Kataoka Y, Lacour JP, et al: SOLO 1 and SOLO 2 investigators: Two phase 3 trials of dupilumab versus placebo in atopic dermatitis. N Engl J Med. 375:2335–2348. 2016. View Article : Google Scholar : PubMed/NCBI

56 

Simpson EL: Dupilumab improves general health-related quality-of-life in patients with moderate-to-severe atopic dermatitis: Pooled results from two randomized, controlled phase 3 clinical trials. Dermatol Ther (Heidelb). 7:243–248. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Blauvelt A, de Bruin-Weller M, Gooderham M, Cather JC, Weisman J, Pariser D, Simpson EL, Papp KA, Hong HC, Rubel D, et al: Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): A 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial. Lancet. 389:2287–2303. 2017. View Article : Google Scholar : PubMed/NCBI

58 

Eichenfield L, Flohr C, Simpson E, DeBusk K, Kin CY and Karl Y: Lebrikizumab improves patient-reported outcomes (PROs) in a phase 2 study in patients with atopic dermatitis. J Am Acad Dermatol. 76:AB423. 2017. View Article : Google Scholar

59 

Hajar T, Gontijo JR and Hanifin JM: New and developing therapies for atopic dermatitis. An Bras Dermatol. 93:104–107. 2018. View Article : Google Scholar : PubMed/NCBI

60 

Snast I, Reiter O, Hodak E, Friedland R, Mimouni D and Leshem YA: Are biologics efficacious in atopic dermatitis? A systematic review and meta-analysis. Am J Clin Dermatol. 19:145–165. 2018. View Article : Google Scholar : PubMed/NCBI

61 

Neis MM, Peters B, Dreuw A, Wenzel J, Bieber T, Mauch C, Krieg T, Stanzel S, Heinrich PC and Merk HF: Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. J Allergy Clin Immunol. 118:930–937. 2006. View Article : Google Scholar : PubMed/NCBI

62 

Bilsborough J, Leung DY, Maurer M, Howell M, Boguniewicz M, Yao L, Storey H, LeCiel C, Harder B and Gross JA: IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. J Allergy Clin Immunol. 117:418–425. 2006. View Article : Google Scholar : PubMed/NCBI

63 

Ruzicka T, Hanifin JM, Furue M, Pulka G, Mlynarczyk I, Wollenberg A, Galus R, Etoh T, Mihara R, Yoshida H, et al: XCIMA Study Group: Anti-interleukin-31 receptor A antibody for atopic dermatitis. N Engl J Med. 376:826–835. 2017. View Article : Google Scholar : PubMed/NCBI

64 

Leonardi CL, Kimball AB, Papp KA, Yeilding N, Guzzo C, Wang Y, Li S, Dooley LT and Gordon KB: PHOENIX 1 study investigators: Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet. 371:1665–1674. 2008. View Article : Google Scholar : PubMed/NCBI

65 

Maeda S, Hayami Y, Naniwa T and Ueda R: The Th17/IL-23 axis and natural immunity in psoriatic arthritis. Int J Rheumatol. 2012:5396832012. View Article : Google Scholar : PubMed/NCBI

66 

Bromley SK, Larson RP, Ziegler SF and Luster AD: IL-23 induces atopic dermatitis-like inflammation instead of psoriasis-like inflammation in CCR2-deficient mice. PLoS One. 8:e581962013. View Article : Google Scholar : PubMed/NCBI

67 

Leonardi S, Cuppari C, Manti S, Filippelli M, Parisi GF, Borgia F, Briuglia S, Cannavò P, Salpietro A, Arrigo T, et al: Serum interleukin 17, interleukin 23, and interleukin 10 values in children with atopic eczema/dermatitis syndrome (AEDS): Association with clinical severity and phenotype. Allergy Asthma Proc. 36:74–81. 2015. View Article : Google Scholar : PubMed/NCBI

68 

Agusti-Mejias A, Messeguer F, García R and Febrer I: Severe refractory atopic dermatitis in an adolescent patient successfully treated with ustekinumab. Ann Dermatol. 25:368–370. 2013. View Article : Google Scholar : PubMed/NCBI

69 

Puya R, Alvarez-López M, Velez A, Casas Asuncion E and Moreno JC: Treatment of severe refractory adult atopic dermatitis with ustekinumab. Int J Dermatol. 51:115–116. 2012. View Article : Google Scholar : PubMed/NCBI

70 

Fernández-Antón Martínez MC, Alfageme Roldán F, Ciudad Blanco C and Suárez Fernández R: Ustekinumab in the treatment of severe atopic dermatitis: A preliminary report of our experience with 4 patients. Actas Dermosifiliogr. 105:312–313. 2014. View Article : Google Scholar : PubMed/NCBI

71 

Shroff A and Guttman-Yassky E: Successful use of ustekinumab therapy in refractory severe atopic dermatitis. JAAD Case Rep. 1:25–26. 2014. View Article : Google Scholar : PubMed/NCBI

72 

Samorano LP, Hanifin JM, Simpson EL and Leshem YA: Inadequate response to ustekinumab in atopic dermatitis - a report of two patients. J Eur Acad Dermatol Venereol. 30:522–523. 2016. View Article : Google Scholar : PubMed/NCBI

73 

Wlodek C, Hewitt H and Kennedy CT: Use of ustekinumab for severe refractory atopic dermatitis in a young teenager. Clin Exp Dermatol. 41:625–627. 2016. View Article : Google Scholar : PubMed/NCBI

74 

Noda S, Suárez-Fariñas M, Ungar B, Kim SJ, de Guzman Strong C, Xu H, Peng X, Estrada YD, Nakajima S, Honda T, et al: The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization. J Allergy Clin Immunol. 136:1254–1264. 2015. View Article : Google Scholar : PubMed/NCBI

75 

Dastidar SG, Rajagopal D and Ray A: Therapeutic benefit of PDE4 inhibitors in inflammatory diseases. Curr Opin Investig Drugs. 8:364–372. 2007.PubMed/NCBI

76 

Hanifin JM and Chan SC: Monocyte phosphodiesterase abnormalities and dysregulation of lymphocyte function in atopic dermatitis. J Invest Dermatol. 105 Suppl 1:84S–88S. 1995. View Article : Google Scholar : PubMed/NCBI

77 

Souness JE, Aldous D and Sargent C: Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors. Immunopharmacology. 47:127–162. 2000. View Article : Google Scholar : PubMed/NCBI

78 

Schafer PH, Parton A, Gandhi AK, Capone L, Adams M, Wu L, Bartlett JB, Loveland MA, Gilhar A, Cheung YF, et al: Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis. Br J Pharmacol. 159:842–855. 2010. View Article : Google Scholar : PubMed/NCBI

79 

Samrao A, Berry TM, Goreshi R and Simpson EL: A pilot study of an oral phosphodiesterase inhibitor (apremilast) for atopic dermatitis in adults. Arch Dermatol. 148:890–897. 2012. View Article : Google Scholar : PubMed/NCBI

80 

Abrouk M, Farahnik B, Zhu TH, Nakamura M, Singh R, Lee K, Lucking SM, Blossom J, Liao W, Koo J, et al: Apremilast treatment of atopic dermatitis and other chronic eczematous dermatoses. J Am Acad Dermatol. 77:177–180. 2017. View Article : Google Scholar : PubMed/NCBI

81 

Saporito RC and Cohen DJ: Apremilast use for moderate-to-severe atopic dermatitis in pediatric patients. Case Rep Dermatol. 8:179–184. 2016. View Article : Google Scholar : PubMed/NCBI

82 

Oldhoff JM, Darsow U, Werfel T, Katzer K, Wulf A, Laifaoui J, Hijnen DJ, Plötz S, Knol EF, Kapp A, et al: Anti-IL-5 recombinant humanized monoclonal antibody (mepolizumab) for the treatment of atopic dermatitis. Allergy. 60:693–696. 2005. View Article : Google Scholar : PubMed/NCBI

83 

Oldhoff JM, Darsow U, Werfel T, Bihari IC, Katzer K, Laifaoui J, Plötz S, Kapp A, Knol EF, Bruijnzeel-Koomen CA, et al: No effect of anti-interleukin-5 therapy (mepolizumab) on the atopy patch test in atopic dermatitis patients. Int Arch Allergy Immunol. 141:290–294. 2006. View Article : Google Scholar : PubMed/NCBI

84 

Buka RL, Resh B, Roberts B, Cunningham BB and Friedlander S: Etanercept is minimally effective in 2 children with atopic dermatitis. J Am Acad Dermatol. 53:358–359. 2005. View Article : Google Scholar : PubMed/NCBI

85 

Jacobi A, Antoni C, Manger B, Schuler G and Hertl M: Infliximab in the treatment of moderate to severe atopic dermatitis. J Am Acad Dermatol. 52:522–526. 2005. View Article : Google Scholar : PubMed/NCBI

86 

Boguniewicz M: Biologic therapy for atopic dermatitis: Moving beyond the practice parameter and guidelines. J Allergy Clin Immunol Pract. 5:1477–1487. 2017. View Article : Google Scholar : PubMed/NCBI

87 

McDonald BS, Jones J and Rustin M: Rituximab as a treatment for severe atopic eczema: Failure to improve in three consecutive patients. Clin Exp Dermatol. 41:45–47. 2016. View Article : Google Scholar : PubMed/NCBI

88 

Roekevisch E, Spuls PI, Kuester D, Limpens J and Schmitt J: Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: A systematic review. J Allergy Clin Immunol. 133:429–438. 2014. View Article : Google Scholar : PubMed/NCBI

89 

Boguniewicz M, Jaffe HS, Izu A, Sullivan MJ, York D, Geha RS and Leung DY: Recombinant gamma interferon in treatment of patients with atopic dermatitis and elevated IgE levels. Am J Med. 88:365–370. 1990. View Article : Google Scholar : PubMed/NCBI

90 

Hanifin JM, Schneider LC, Leung DY, Ellis CN, Jaffe HS, Izu AE, Bucalo LR, Hirabayashi SE, Tofte SJ, Cantu-Gonzales G, et al: Recombinant interferon gamma therapy for atopic dermatitis. J Am Acad Dermatol. 28:189–197. 1993. View Article : Google Scholar : PubMed/NCBI

91 

Schneider LC, Baz Z, Zarcone C and Zurakowski D: Long-term therapy with recombinant interferon-gamma (rIFN-gamma) for atopic dermatitis. Ann Allergy Asthma Immunol. 80:263–268. 1998. View Article : Google Scholar : PubMed/NCBI

92 

Stevens SR, Hanifin JM, Hamilton T, Tofte SJ and Cooper KD: Long-term effectiveness and safety of recombinant human interferon gamma therapy for atopic dermatitis despite unchanged serum IgE levels. Arch Dermatol. 134:799–804. 1998. View Article : Google Scholar : PubMed/NCBI

93 

Takiguchi R, Tofte S, Simpson B, Harper E, Blauvelt A, Hanifin J and Simpson E: Efalizumab for severe atopic dermatitis: A pilot study in adults. J Am Acad Dermatol. 56:222–227. 2007. View Article : Google Scholar : PubMed/NCBI

94 

Moul DK, Routhouska SB, Robinson MR and Korman NJ: Alefacept for moderate to severe atopic dermatitis: A pilot study in adults. J Am Acad Dermatol. 58:984–989. 2008. View Article : Google Scholar : PubMed/NCBI

95 

Werfel T, Breuer K, Ruéff F, Przybilla B, Worm M, Grewe M, Ruzicka T, Brehler R, Wolf H, Schnitker J, et al: Usefulness of specific immunotherapy in patients with atopic dermatitis and allergic sensitization to house dust mites: A multi-centre, randomized, dose-response study. Allergy. 61:202–205. 2006. View Article : Google Scholar : PubMed/NCBI

96 

Bae JM, Choi YY, Park CO, Chung KY and Lee KH: Efficacy of allergen-specific immunotherapy for atopic dermatitis: A systematic review and meta-analysis of randomized controlled trials. J Allergy Clin Immunol. 132:110–117. 2013. View Article : Google Scholar : PubMed/NCBI

97 

Novak N, Bieber T, Hoffmann M, Fölster-Holst R, Homey B, Werfel T, Sager A and Zuberbier T: Efficacy and safety of subcutaneous allergen-specific immunotherapy with depigmented polymerized mite extract in atopic dermatitis. J Allergy Clin Immunol. 130:925–31.e4. 2012. View Article : Google Scholar : PubMed/NCBI

98 

Gendelman SR and Lang DM: Specific immunotherapy in the treatment of atopic dermatitis: A systematic review using the GRADE system. Ann Allergy Asthma Immunol. 111:555–561. 2013. View Article : Google Scholar : PubMed/NCBI

99 

Qin YE, Mao JR, Sang YC and Li WX: Clinical efficacy and compliance of sublingual immunotherapy with Dermatophagoides farinae drops in patients with atopic dermatitis. Int J Dermatol. 53:650–655. 2014. View Article : Google Scholar : PubMed/NCBI

100 

Pajno GB, Caminiti L, Vita D, Barberio G, Salzano G, Lombardo F, Canonica GW and Passalacqua G: Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: A randomized, double-blind, placebo-controlled study. J Allergy Clin Immunol. 120:164–170. 2007. View Article : Google Scholar : PubMed/NCBI

101 

Mastrandrea F, Serio G, Minelli M, Minardi A, Scarcia G, Coradduzza G and Parmiani S: Specific sublingual immunotherapy in atopic dermatitis. Results of a 6-year follow-up of 35 consecutive patients. Allergol Immunopathol (Madr). 28:54–62. 2000.PubMed/NCBI

102 

Darsow U: Allergen-specific immunotherapy for atopic eczema: Updated. Curr Opin Allergy Clin Immunol. 12:665–669. 2012. View Article : Google Scholar : PubMed/NCBI

103 

Bissonnette R, Papp KA, Poulin Y, Gooderham M, Raman M, Mallbris L, Wang C, Purohit V, Mamolo C, Papacharalambous J, et al: Topical tofacitinib for atopic dermatitis: A phase IIa randomized trial. Br J Dermatol. 175:902–911. 2016. View Article : Google Scholar : PubMed/NCBI

104 

Paller AS, Tom WL, Lebwohl MG, Blumenthal RL, Boguniewicz M, Call RS, Eichenfield LF, Forsha DW, Rees WC, Simpson EL, et al: Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults. J Am Acad Dermatol. 75:494–503.e6. 2016. View Article : Google Scholar : PubMed/NCBI

105 

Hanifin JM, Chan SC, Cheng JB, Tofte SJ, Henderson WR Jr, Kirby DS and Weiner ES: Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis. J Invest Dermatol. 107:51–56. 1996. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Deleanu D and Nedelea I: Biological therapies for atopic dermatitis: An update (Review). Exp Ther Med 17: 1061-1067, 2019.
APA
Deleanu, D., & Nedelea, I. (2019). Biological therapies for atopic dermatitis: An update (Review). Experimental and Therapeutic Medicine, 17, 1061-1067. https://doi.org/10.3892/etm.2018.6989
MLA
Deleanu, D., Nedelea, I."Biological therapies for atopic dermatitis: An update (Review)". Experimental and Therapeutic Medicine 17.2 (2019): 1061-1067.
Chicago
Deleanu, D., Nedelea, I."Biological therapies for atopic dermatitis: An update (Review)". Experimental and Therapeutic Medicine 17, no. 2 (2019): 1061-1067. https://doi.org/10.3892/etm.2018.6989
Copy and paste a formatted citation
x
Spandidos Publications style
Deleanu D and Nedelea I: Biological therapies for atopic dermatitis: An update (Review). Exp Ther Med 17: 1061-1067, 2019.
APA
Deleanu, D., & Nedelea, I. (2019). Biological therapies for atopic dermatitis: An update (Review). Experimental and Therapeutic Medicine, 17, 1061-1067. https://doi.org/10.3892/etm.2018.6989
MLA
Deleanu, D., Nedelea, I."Biological therapies for atopic dermatitis: An update (Review)". Experimental and Therapeutic Medicine 17.2 (2019): 1061-1067.
Chicago
Deleanu, D., Nedelea, I."Biological therapies for atopic dermatitis: An update (Review)". Experimental and Therapeutic Medicine 17, no. 2 (2019): 1061-1067. https://doi.org/10.3892/etm.2018.6989
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team