Biological therapies for atopic dermatitis: An update (Review)

  • Authors:
    • Diana Deleanu
    • Irena Nedelea
  • View Affiliations

  • Published online on: November 19, 2018     https://doi.org/10.3892/etm.2018.6989
  • Pages: 1061-1067
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Abstract

Severe atopic dermatitis, which affects both adults and children, is a debilitating disorder with a significant decline of patients' quality of life. Although aetiopathogenic factors are currently a topic of study and interpretation, the main features of atopic eczema are skin barrier disturbance and immune dysregulation. Severe refractory disease that fails to improve with conventional therapy may benefit from biologic therapy. Progress in understanding immunopathology of atopic dermatitis have allowed identification of therapeutic molecular targets in the field of biological therapy. We reviewed the different biological treatments with a focus on novel targeted agents: Systemic immunotherapy (Omalizumab, Dupilumab, Lebrikizumab, Tralokinumab, Nemolizumab, Ustekinumab, Fezakinumab, Tezepelumab, Apremilast, allergen specific immunotherapy), and topical agents (Tofacitinib, Crisaborole).
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February-2019
Volume 17 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Deleanu D and Deleanu D: Biological therapies for atopic dermatitis: An update (Review). Exp Ther Med 17: 1061-1067, 2019
APA
Deleanu, D., & Deleanu, D. (2019). Biological therapies for atopic dermatitis: An update (Review). Experimental and Therapeutic Medicine, 17, 1061-1067. https://doi.org/10.3892/etm.2018.6989
MLA
Deleanu, D., Nedelea, I."Biological therapies for atopic dermatitis: An update (Review)". Experimental and Therapeutic Medicine 17.2 (2019): 1061-1067.
Chicago
Deleanu, D., Nedelea, I."Biological therapies for atopic dermatitis: An update (Review)". Experimental and Therapeutic Medicine 17, no. 2 (2019): 1061-1067. https://doi.org/10.3892/etm.2018.6989