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Analysis of the relationship between Oxford classification,IgM deposition and multiple indexes and the adverseprognosis of patients with primary IgA nephropathy and related risk factors

  • Authors:
    • Yan Hao
    • Yuliang Zhao
    • Rongshuang Huang
    • Ping Fu
  • View Affiliations / Copyright

    Affiliations: Division of Nephrology, Kidney Research Laboratory, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Hao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1234-1239
    |
    Published online on: December 5, 2018
       https://doi.org/10.3892/etm.2018.7050
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Abstract

The risk and influencing factors of prognosis in patients with primary IgA nephropathy (IgAN) were explored. One hundred and twenty-four patients who were diagnosed with IgA nephropathy in West China Hospital of Sichuan University were selected as the study subjects. The baseline data were recorded. All patients were followed up for 3 years. Patients with poor prognosis were defined as poor prognosis group, and the patient with no adverse prognosis was defined as a good prognosis group during the follow-up period. The risk factors that may affect the prognosis of patients with IgAN were analyzed by single factor analysis. The influence of all factors that were statistically significant on the prognosis of the patients was further evaluated by multifactor Cox regression. The single factor analysis and multivariate Cox proportional hazard model showed that patients with 24 h urinary protein, pathological type, Oxford classification (T1+T2), Lee (grade IV) and mesangial IgM deposition were independent factors of patients, and the difference was statistically significant, their P-values were 0.041, 0.046, 0.037, 0.043, and 0.028, respectively. Patients with 24 h urinary protein, pathological type, Oxford classification (T1+T2), Lee (grade IV) and mesangial IgM deposition can be used as independent factors affecting poor prognosis in primary IgAN patients. It provides evidence for early detection of high-risk IgA nephropathy.
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1 

Al Hussain T, Hussein MH, Al Mana H and Akhtar M: Pathophysiology of iga nephropathy. Adv Anat Pathol. 24:56–62. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Daha MR and van Kooten C: Role of complement in IgA nephropathy. J Nephrol. 29:1–4. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Kusano T, Takano H, Kang D, Nagahama K, Aoki M, Morita M, Kaneko T, Tsuruoka S and Shimizu A: Endothelial cell injury in acute and chronic glomerular lesions in patients with IgA nephropathy. Hum Pathol. 49:135–144. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Yabuki A, Shimokawa Miyama T, Kohyama M and Yamato O: Canine IgA nephropathy: A case report. J Vet Med Sci. 78:513–515. 2016. View Article : Google Scholar : PubMed/NCBI

5 

da Silva LS, Almeida BL, de Melo AK, de Brito DC, Braz AS and Freire EA: IgA nephropathy in systemic lupus erythematosus patients: Case report and literature review. Rev Bras Reumatol Engl Ed. 56:270–273. 2016.PubMed/NCBI

6 

Ohata C, Ishii N, Koga H and Nakama T: A clinical and serological study of linear IgA bullous dermatosis without linear immunoglobulin deposition other than IgA at the basement membrane zone using direct immunofluorescence. Br J Dermatol. 177:152–157. 2017. View Article : Google Scholar : PubMed/NCBI

7 

D'Amico G: Natural history of idiopathic IgA nephropathy and factors predictive of disease outcome. Semin Nephrol. 24:179–196. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Lv J, Hou W, Zhou X, Liu G, Zhou F, Zhao N, Hou P, Zhao M and Zhang H: Interaction between PLA2R1 and HLA-DQA1 variants associates with anti-PLA2R antibodies and membranous nephropathy. J Am Soc Nephrol. 24:1323–1329. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Patterson R, Schatz M, Fink JN, DeSwarte RS, Roberts M and Cugell D: Pigeons breeders' disease. I. Serum immunoglobulin concentrations; IgG, IgM, IgA and IgE antibodies against pigeon serum. Am J Med. 60:144–151. 1976. View Article : Google Scholar : PubMed/NCBI

10 

Han B, Li Y, Han H, Zhao Y, Pan Q and Ren L: Three IgH isotypes, IgM, IgA and IgY are expressed in Gentoo penguin and zebra finch. PLoS One. 12:e01733342017. View Article : Google Scholar : PubMed/NCBI

11 

Lin Q, Chen Y, Lv J, Zhang H, Tang J, Gunaratnam L, Li X and Yang L: Kidney injury molecule-1 expression in IgA nephropathy and its correlation with hypoxia and tubulointerstitial inflammation. Am J Physiol Renal Physiol. 306:885–895. 2014. View Article : Google Scholar

12 

Sonoda Y, Gohda T, Suzuki Y, Omote K, Ishizaka M, Matsuoka J and Tomino Y: Circulating TNF receptors 1 and 2 are associated with the severity of renal interstitial fibrosis in IgA nephropathy. PLoS One. 10:e01222122015. View Article : Google Scholar : PubMed/NCBI

13 

Kosztyu P, Hill M, Jemelkova J, Czernekova L, Kafkova LR, Hruby M, Matousovic K, Vondrak K, Zadrazil J and Sterzl I: Glucocorticoids reduce aberrant O-Glycosylation of IgA1 in IgA nephropathy patients. Kidney Blood Press Res. 43:350–359. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Lloyd IE, Ahmed F, Revelo MP and Khalighi MA: De novo immune complex deposition in kidney allografts: A series of 32 patients. Hum Pathol. 71:109–116. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Wu CK, Yang AH, Lai HC and Lin BS: Combined proximal tubulopathy, crystal-storing histiocytosis, and cast nephropathy in a patient with light chain multiple myeloma. BMC Nephrol. 18:1702017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hao Y, Zhao Y, Huang R and Fu P: Analysis of the relationship between Oxford classification,IgM deposition and multiple indexes and the adverseprognosis of patients with primary IgA nephropathy and related risk factors. Exp Ther Med 17: 1234-1239, 2019.
APA
Hao, Y., Zhao, Y., Huang, R., & Fu, P. (2019). Analysis of the relationship between Oxford classification,IgM deposition and multiple indexes and the adverseprognosis of patients with primary IgA nephropathy and related risk factors. Experimental and Therapeutic Medicine, 17, 1234-1239. https://doi.org/10.3892/etm.2018.7050
MLA
Hao, Y., Zhao, Y., Huang, R., Fu, P."Analysis of the relationship between Oxford classification,IgM deposition and multiple indexes and the adverseprognosis of patients with primary IgA nephropathy and related risk factors". Experimental and Therapeutic Medicine 17.2 (2019): 1234-1239.
Chicago
Hao, Y., Zhao, Y., Huang, R., Fu, P."Analysis of the relationship between Oxford classification,IgM deposition and multiple indexes and the adverseprognosis of patients with primary IgA nephropathy and related risk factors". Experimental and Therapeutic Medicine 17, no. 2 (2019): 1234-1239. https://doi.org/10.3892/etm.2018.7050
Copy and paste a formatted citation
x
Spandidos Publications style
Hao Y, Zhao Y, Huang R and Fu P: Analysis of the relationship between Oxford classification,IgM deposition and multiple indexes and the adverseprognosis of patients with primary IgA nephropathy and related risk factors. Exp Ther Med 17: 1234-1239, 2019.
APA
Hao, Y., Zhao, Y., Huang, R., & Fu, P. (2019). Analysis of the relationship between Oxford classification,IgM deposition and multiple indexes and the adverseprognosis of patients with primary IgA nephropathy and related risk factors. Experimental and Therapeutic Medicine, 17, 1234-1239. https://doi.org/10.3892/etm.2018.7050
MLA
Hao, Y., Zhao, Y., Huang, R., Fu, P."Analysis of the relationship between Oxford classification,IgM deposition and multiple indexes and the adverseprognosis of patients with primary IgA nephropathy and related risk factors". Experimental and Therapeutic Medicine 17.2 (2019): 1234-1239.
Chicago
Hao, Y., Zhao, Y., Huang, R., Fu, P."Analysis of the relationship between Oxford classification,IgM deposition and multiple indexes and the adverseprognosis of patients with primary IgA nephropathy and related risk factors". Experimental and Therapeutic Medicine 17, no. 2 (2019): 1234-1239. https://doi.org/10.3892/etm.2018.7050
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