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Article

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

  • Authors:
    • Ilinca Nicolae
    • Mircea Tampa
    • Corina Daniela Ene
    • Cristina Iulia Mitran
    • Madalina Irina Mitran
    • Maria Isabela Sarbu
    • Clara Matei
    • Cosmin Ene
    • Simona Roxana Georgescu
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, ‘Victor Babes’ Clinical Hospital for Infectious Diseases, 030303 Bucharest, Romania, Department of Nephrology, ‘Carol Davila’ Nephrology Hospital, 010731 Bucharest, Romania, Department of Dermatology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Urology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
  • Pages: 1012-1019
    |
    Published online on: December 5, 2018
       https://doi.org/10.3892/etm.2018.7053
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Abstract

Recent data suggest that severe psoriasis is an independent risk factor for chronic renal disease. In the present study, we investigated the role of related-purine derivatives as predictors of renal dysfunctions in patients with psoriasis. A prospective study was conducted on a group of 45 patients with psoriasis vulgaris and 45 control cases, monitored over a 5-year period. Alterations of renal function, albumin/creatinine ratio (ACR, mg/g) and UA/creatinine ratio (UACR, mg/mg) were determined in spontaneous urine samples. The status of related-purine derivatives was evaluated by quantification of uric acid (UA, mg/dl), adenosine deaminase (ADA, UI/mg protein), xanthine oxidase (XO, UI/mg protein) and 8-hydroxy-deoxy-guanosine levels (8-OHdG, ng/ml) in serum samples. Compared to the controls, in patients with psoriasis there was an increase in related-purine derivatives levels, which was demonstrated by the elevated serum levels of UA (5.1±0.4 vs. 5.4±1.0, P=0.066), ADA (0.14±0.08 vs. 0.29±0.12, P=0.052), XO (0.22±0.11 vs. 0.42±0.21, P=0.011) and 8-OHdG (3.1±0.05 vs. 8.3±4.7, P=0.002). The serum levels of related-purine derivatives were associated with the severity of psoriasis. In addition, there was a link between the serum levels of related-purine derivatives and markers of renal impairment. There were positive correlations between 8-OHdG and ACR (r=0.452, P=0.028) and between ADA, XO, UA, 8-OHdG and UACR (r=0.297 and P=0.032, r=0.301 and P=0.002, r=0.431 and P=0.027, r=0.508 and P=0.002) and negative correlations between UA, 8-OHdG and the estimated glomerular filtration rate (r=-0.301 and P=0.036, r=-0.384 and P=0.002). Thus, severe psoriasis is a risk factor for the development of renal disease.
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Copy and paste a formatted citation
Spandidos Publications style
Nicolae I, Tampa M, Ene CD, Mitran CI, Mitran MI, Sarbu MI, Matei C, Ene C and Georgescu SR: Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris. Exp Ther Med 17: 1012-1019, 2019.
APA
Nicolae, I., Tampa, M., Ene, C.D., Mitran, C.I., Mitran, M.I., Sarbu, M.I. ... Georgescu, S.R. (2019). Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris. Experimental and Therapeutic Medicine, 17, 1012-1019. https://doi.org/10.3892/etm.2018.7053
MLA
Nicolae, I., Tampa, M., Ene, C. D., Mitran, C. I., Mitran, M. I., Sarbu, M. I., Matei, C., Ene, C., Georgescu, S. R."Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris". Experimental and Therapeutic Medicine 17.2 (2019): 1012-1019.
Chicago
Nicolae, I., Tampa, M., Ene, C. D., Mitran, C. I., Mitran, M. I., Sarbu, M. I., Matei, C., Ene, C., Georgescu, S. R."Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris". Experimental and Therapeutic Medicine 17, no. 2 (2019): 1012-1019. https://doi.org/10.3892/etm.2018.7053
Copy and paste a formatted citation
x
Spandidos Publications style
Nicolae I, Tampa M, Ene CD, Mitran CI, Mitran MI, Sarbu MI, Matei C, Ene C and Georgescu SR: Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris. Exp Ther Med 17: 1012-1019, 2019.
APA
Nicolae, I., Tampa, M., Ene, C.D., Mitran, C.I., Mitran, M.I., Sarbu, M.I. ... Georgescu, S.R. (2019). Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris. Experimental and Therapeutic Medicine, 17, 1012-1019. https://doi.org/10.3892/etm.2018.7053
MLA
Nicolae, I., Tampa, M., Ene, C. D., Mitran, C. I., Mitran, M. I., Sarbu, M. I., Matei, C., Ene, C., Georgescu, S. R."Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris". Experimental and Therapeutic Medicine 17.2 (2019): 1012-1019.
Chicago
Nicolae, I., Tampa, M., Ene, C. D., Mitran, C. I., Mitran, M. I., Sarbu, M. I., Matei, C., Ene, C., Georgescu, S. R."Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris". Experimental and Therapeutic Medicine 17, no. 2 (2019): 1012-1019. https://doi.org/10.3892/etm.2018.7053
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