Open Access

Correlation of gestational hypertension with abnormal lipid metabolism, insulin resistance and D-dimer and their clinical significance

  • Authors:
    • Yan Jin
    • Haixia Xu
    • Miaoqing Wu
    • Bixia Yi
    • Min Zhu
    • Yi Zhou
    • Jianfang Wang
  • View Affiliations

  • Published online on: December 7, 2018     https://doi.org/10.3892/etm.2018.7070
  • Pages: 1346-1350
  • Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Correlation of gestational hypertension with abnormal lipid metabolism, insulin resistance and D-dimer were investigated. Seventy-three patients with gestational hypertension in Jinhua People's Hospital were selected as the observation group and 70 healthy gestational subjects were selected as the control group. The indexes of lipid metabolism, insulin resistance index [homeostasis model assessment (HOMA)] and the level of D-dimer in the two groups were compared and the correlation of gestational hypertension with the changes in lipid metabolism, insulin resistance and D-dimer was analyzed. The level of HDL-C (high-density lipoprotein cholesterol) in the observation group was significantly lower than that in the control group (P<0.05), while the levels of other indexes were all significantly higher than those in the control group (P<0.05). HOMA index and D-dimer in the observation group were both significantly higher than those in the control group (P<0.05). TG was positively correlated with gestational hypertension (r=0.8767, P<0.01). The correlation analysis of HOMA and gestational hypertension showed positive correlation (r=0.8819, P<0.01). In addition, D-dimer was positively correlated with gestational hypertension (r=0.8933, P<0.01). Lipid metabolism indexes are abnormal in patients with gestational hypertension as well as for insulin resistance index and D-dimer. Besides, the above-mentioned indexes are all correlated with the patients with gestational hypertension. Therefore, more observations should be made on lipid metabolism indexes, insulin resistance and D-dimer in the future treatment of gestational hypertension.
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February-2019
Volume 17 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Jin Y, Xu H, Wu M, Yi B, Zhu M, Zhou Y and Wang J: Correlation of gestational hypertension with abnormal lipid metabolism, insulin resistance and D-dimer and their clinical significance. Exp Ther Med 17: 1346-1350, 2019
APA
Jin, Y., Xu, H., Wu, M., Yi, B., Zhu, M., Zhou, Y., & Wang, J. (2019). Correlation of gestational hypertension with abnormal lipid metabolism, insulin resistance and D-dimer and their clinical significance. Experimental and Therapeutic Medicine, 17, 1346-1350. https://doi.org/10.3892/etm.2018.7070
MLA
Jin, Y., Xu, H., Wu, M., Yi, B., Zhu, M., Zhou, Y., Wang, J."Correlation of gestational hypertension with abnormal lipid metabolism, insulin resistance and D-dimer and their clinical significance". Experimental and Therapeutic Medicine 17.2 (2019): 1346-1350.
Chicago
Jin, Y., Xu, H., Wu, M., Yi, B., Zhu, M., Zhou, Y., Wang, J."Correlation of gestational hypertension with abnormal lipid metabolism, insulin resistance and D-dimer and their clinical significance". Experimental and Therapeutic Medicine 17, no. 2 (2019): 1346-1350. https://doi.org/10.3892/etm.2018.7070