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A complex translocation (1;17;15) with spliced short‑type PML‑RARA fusion transcripts in acute promyelocytic leukemia: A case report

  • Authors:
    • Lili Lv
    • Longfei Yang
    • Honghua Cui
    • Tonghui Ma
  • View Affiliations / Copyright

    Affiliations: Department of Oncology and Hematology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China, Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China
    Copyright: © Lv et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1360-1366
    |
    Published online on: December 13, 2018
       https://doi.org/10.3892/etm.2018.7091
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Abstract

The promyelocytic leukemia (PML)‑retinoic acid receptor α (RARA) fusion is hypothesized to serve a vital role in the pathogenesis of acute promyelocytic leukemia (APL), which results from a reciprocal translocation between chromosomes 15 and 17, t(15;17)(q24;q21). A minority of APL cases lack the classical t(15;17) and have been identified to have cryptic or masked t(15;17) or complex translocations. The present study reports on a case of a 37‑year‑old male with APL harboring a complex three‑way translocation t(1;17;15)(q21;q21;q24). This karyotypic interpretation was further confirmed by fluorescence in situ hybridization, and 98% of the bone marrow cells analyzed were positive for the PML‑RARA fusion gene. After combined treatment with all‑trans retinoic acid and arsenic trioxide, the patient achieved complete remission with no recurrence for 3 years to date. To the best of our knowledge, the present study is the first to report on the novel variant of t(15;17) involving the breakpoint 1q21.
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Copy and paste a formatted citation
Spandidos Publications style
Lv L, Yang L, Cui H and Ma T: A complex translocation (1;17;15) with spliced short‑type PML‑RARA fusion transcripts in acute promyelocytic leukemia: A case report. Exp Ther Med 17: 1360-1366, 2019.
APA
Lv, L., Yang, L., Cui, H., & Ma, T. (2019). A complex translocation (1;17;15) with spliced short‑type PML‑RARA fusion transcripts in acute promyelocytic leukemia: A case report. Experimental and Therapeutic Medicine, 17, 1360-1366. https://doi.org/10.3892/etm.2018.7091
MLA
Lv, L., Yang, L., Cui, H., Ma, T."A complex translocation (1;17;15) with spliced short‑type PML‑RARA fusion transcripts in acute promyelocytic leukemia: A case report". Experimental and Therapeutic Medicine 17.2 (2019): 1360-1366.
Chicago
Lv, L., Yang, L., Cui, H., Ma, T."A complex translocation (1;17;15) with spliced short‑type PML‑RARA fusion transcripts in acute promyelocytic leukemia: A case report". Experimental and Therapeutic Medicine 17, no. 2 (2019): 1360-1366. https://doi.org/10.3892/etm.2018.7091
Copy and paste a formatted citation
x
Spandidos Publications style
Lv L, Yang L, Cui H and Ma T: A complex translocation (1;17;15) with spliced short‑type PML‑RARA fusion transcripts in acute promyelocytic leukemia: A case report. Exp Ther Med 17: 1360-1366, 2019.
APA
Lv, L., Yang, L., Cui, H., & Ma, T. (2019). A complex translocation (1;17;15) with spliced short‑type PML‑RARA fusion transcripts in acute promyelocytic leukemia: A case report. Experimental and Therapeutic Medicine, 17, 1360-1366. https://doi.org/10.3892/etm.2018.7091
MLA
Lv, L., Yang, L., Cui, H., Ma, T."A complex translocation (1;17;15) with spliced short‑type PML‑RARA fusion transcripts in acute promyelocytic leukemia: A case report". Experimental and Therapeutic Medicine 17.2 (2019): 1360-1366.
Chicago
Lv, L., Yang, L., Cui, H., Ma, T."A complex translocation (1;17;15) with spliced short‑type PML‑RARA fusion transcripts in acute promyelocytic leukemia: A case report". Experimental and Therapeutic Medicine 17, no. 2 (2019): 1360-1366. https://doi.org/10.3892/etm.2018.7091
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