Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2019 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2019 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation

  • Authors:
    • Yaolong Wang
    • Zhaoxia Ma
    • Yuanyuan Zheng
    • Baoling Liu
    • Pengfei Bao
    • Xingfei Wu
    • Congtao Yu
    • Zhengqi Wen
    • Tiekun Ma
    • Jinxue Liu
    • Change Liu
    • Daiping Ma
    • Haiying Wu
    • Jun Li
    • Yong Yuan
    • Ning Lu
    • Hongbin Zhao
    • Yanjiao Li
    • Suping Yang
    • Rongping Zhang
    • Jiejie Dai
    • Min Hu
  • View Affiliations / Copyright

    Affiliations: Yunnan Key Laboratory for Basic Research on Bone and Joint Diseases and Yunnan Stem Cell Translational Research Center, Kunming University, Kunming, Yunnan 650214, P.R. China, Department of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China, Department of Orthopaedics, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, P.R. China, Department of Orthopaedics, First People's Hospital of Yunnan Province, Kunming, Yunnan 650011, P.R. China, Department of Pharmacy, Kunming Medical University, Kunming, Yunnan 650500, P.R. China, Center of Tree Shrew Germplasm Resources, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan 650118, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3644-3654
    |
    Published online on: March 4, 2019
       https://doi.org/10.3892/etm.2019.7339
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Osteoporosis (OP) treatment has always been challenging for elderly menopausal females. An animal model with a closer genetic association to human OP is essential for treatment research. Given its close genetic association to primates, the tree shrew is a suitable candidate for meeting the requirements for such an animal model. In the present study, a tree shrew OP model induced by ovariectomy (OVX), was established. Evaluation by multiple analysis methods, including blood biochemical indicators, uterus coefficients, micro‑computed tomography analysis, histochemical analysis and scanning electron microscopic observation indicated that OVX was an appropriate method to establish the OP model in tree shrews. In addition, the biomolecular characteristics of OVX‑induced osteoporosis were also assessed by transcriptome sequencing and bioinformatics analysis. The present study provides the methods used to confirm the successful establishment of the OP model in tree shrew, and suggests that the OP model is appropriate for human OP research.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Jackson RD and Mysiw WJ: Insights into the epidemiology of postmenopausal osteoporosis: The women's health initiative. Semin Reprod Med. 32:454–462. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Liu Z, Piao J, Pang L, Qing X, Nan S, Pan Z, Guo Y, Wang X, Li F, Liu J and Cheng X: The diagnostic criteria for primary osteoporosis and the incidence of osteoporosis in China. J Bone Miner Metab. 20:181–189. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Black DM, Arden NK, Palermo L, Pearson J and Cummings SR: Prevalent vertebral deformities predict hip fractures and new vertebral deformities but not wrist fractures. study of osteoporotic fractures research group. J Bone Miner Res. 14:821–828. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Dolan P and Torgerson DJ: The cost of treating osteoporotic fractures in the United Kingdom female population. Osteoporos Int. 8:611–617. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Graham SM, Howgate D, Anderson W, Howes C, Heliotis M, Mantalaris A, Tsiridis E and Tsapakis E: Risk of osteoporosis and fracture incidence in patients on antipsychotic medication. Expert Opin Drug Saf. 10:575–602. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Komori T: Animal models for osteoporosis. Eur J Pharmacol. 759:287–294. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Dias IR, Camassa JA, Bordelo JA, Babo PS, Viegas CA, Dourado N, Reis RL and Gomes ME: Preclinical and translational studies in small ruminants (sheep and goat) as models for osteoporosis research. Curr Osteoporos Rep. 16:182–197. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Glebe D and Bremer CM: The molecular virology of hepatitis B virus. Semin Liver Dis. 33:103–112. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Xiao J, Liu R and Chen CS: Tree shrew (Tupaia belangeri) as a novel laboratory disease animal model. Zool Res. 38:127–137. 2017.PubMed/NCBI

10 

Moore E: Medical relevance of UK-funded non-human primateresearch published from January 1997 to July 2012. J R Soc Med. 107:264–270. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Xu L, Chen SY, Nie WH, Jiang XL and Yao YG: Evaluating the phylogenetic position of Chinese tree shrew (Tupaia belangeri chinensis) based on complete mitochondrial genome: Implication for using tree shrew as an alternative experimental animal to primates in biomedical research. J Genet Genomics. 39:131–137. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Xu L, Zhang Y, Liang B, Lü LB, Chen CS, Chen YB, Zhou JM and Yao YG: Tree shrews under the spot light: Emerging model of human diseases. Dongwuxue Yanjiu. 34:59–69. 2013.(In Chinese). PubMed/NCBI

13 

Baldwin MK, Wei H, Reed JL, Bickford ME, Petry HM and Kaas JH: Cortical projections to the superior colliculus in tree shrews (Tupaia belangeri). J Comp Neurol. 521:1614–1632. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Petruzziello F, Fouillen L, Wadensten H, Kretz R, Andren PE, Rainer G and Zhang X: Extensive characterization of Tupaia belangeri neuropeptidome using an integrated mass spectrometric approach. J Proteome Res. 11:886–896. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Zhang XH, Dai ZX, Zhang GH, Han JB and Zheng YT: Molecular characterization, balancing selection, and genomic organization of the tree shrew (Tupaia belangeri) MHC class I gene. Gene. 522:147–155. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Wu X, Chang Q, Zhang Y, Zou X, Chen L, Zhang L, Lv L and Liang B: Relationships between body weight, fasting blood glucose concentration, sex and age in tree shrews (Tupaia belangeri chinensis). J Anim Physiol Anim Nutr (Berl). 7:1179–1188. 2013. View Article : Google Scholar

17 

Xing HJ, Jia K, He J, Shi C, Fang M, Song L, Zhang P, Zhao Y, Fu J and Li S: Establishment of the tree shrew as an alcohol-induced fatty liver model for the study of alcoholic liver diseases. PLoS One. 10:e01282532015. View Article : Google Scholar : PubMed/NCBI

18 

Young PA: Genomic evidence supported tree shrew is closely related to primates. Int J Mol Evol Biodivers. 3:1–4. 2013.

19 

Fan Y, Huang ZY, Cao CC, Chen CS, Chen YX, Fan DD, He J, Hou HL, Hu L, Hu XT, et al: Genome of the Chinese tree shrew. Nat Commun. 4:14262013. View Article : Google Scholar : PubMed/NCBI

20 

Ye LH, Meng HE, Huang YC, Zhao GQ, Lei YJ, Zhou YC and Chen XB: Tree shrew as a new animal model for the study of lung cancer. Oncol Lett. 11:2091–2095. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Yang F, Li YJ, Wang YL, Wang YJ, Dai JJ and Hu M: Establishment of tree shrew osteoporosis model by bilateral ovariectomy. J Kunming Medical Univ. 1:24–27. 2016.(In Chinese).

22 

Zhu MC, Li H, Gyanwali B, He GY, Qi CL, Yang XM, Li ZH, Yao ZX, Wang Z and Tang A: Auditory brainstem responses after electrolytic lesions in bilateral subdivisions of the medial geniculate body of tree shrews. Neurol Sci. 38:1617–1628. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Chandra A, Wang L, Young T, Zhong L, Tseng WJ, Levine MA, Cengel K, Liu XS, Zhang Y, Pignolo RJ and Qin L: Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis. FASEB J. 32:52–62. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Tanaka S, Haji M, Takayanagi R, Tanaka S, Sugioka Y and Nawata H: 1,25-Dihydroxyvitamin D3 enhances the enzymatic activity and expression of the messenger ribonucleic acid for aromatase cytochrome P450 synergistically with dexamethasone depending on the vitamin D receptor level in cultured human osteoblasts. Endocrinology. 37:1860–1869. 1996. View Article : Google Scholar

25 

Noronha-Matos JB and Correia-de-Sá P: Mesenchymal stem cells ageing: Targeting the ‘purinome’ to promote osteogenic differentiation and bone repair. J Cell Physiol. 231:1852–1861. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Harkema L, Youssef SA and de Bruin A: Pathology of mouse models of accelerated aging. Vet Pathol. 53:366–389. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Jee WS and Yao W: Overview: Animal models of osteopenia and osteoporosis. J Musculoskel Neuron Interact. 1:193–207. 2001.

28 

Li B, Zhang RP, Li JT, He BL, Zhen H, Wang LM and Jiao JL: Measurement and analysis of anatomical parameter values in tree shrews. Dongwuxue Yanjiu. 34:132–138. 2013.(In Chinese). PubMed/NCBI

29 

Han YY, Xu X, Lu CX, Kuang DX, Quan PF, Wang WG, Sun XM, Li N and Dai JJ: Establishment of CT 3 D visualization models and analysis of the skeletal system in adult tree shrews. Acta Lab Anim Sci Sin. 25:153–159. 2017.(In Chinese).

30 

Kobayashi Y and Tokue A: Clinical usefulness of blood PICP, PINP and ICTP concentrations as bone metastasis markers in prostate cancer patients. Nihon Rinsho. 56:2072–2076. 1998.(In Japanese). PubMed/NCBI

31 

Haarhaus M, Monier-Faugere MC, Magnusson P and Malluche HH: Bone alkaline phosphatase isoforms in hemodialysis patients with low versus non-low bone turnover: A diagnostic test study. Am J Kidney Dis. 66:99–105. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Zhao D, Wang J, Liu Y and Liu X: Expressions and clinical significance of serum bone Gla-protein, bone alkaline phosphatase and C-terminal telopeptide of type I collagen in bone metabolism of patients with osteoporosis. Pak J Med Sci. 31:91–94. 2015.PubMed/NCBI

33 

Funck-Brentano T, Biver E, Chopin F, Bouvard B, Coiffier G, Souberbielle JC, Garnero P and Roux C: Clinical utility of serum bone turnover markers in postmenopausal osteoporosis therapy monitoring: A systematic review. Semin Arthritis Rheum. 41:157–169. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Li XP, Liu XY, Fan B and Li XY: Early changes in bone specific turnover markers during the healing process of vertebral fracture. Chin J Osteoporosis Bone Miner Res. 8:305–311. 2015.(In Chinese).

35 

Azuma Y, Kaji K, Katogi R, Takeshita S and Kudo A: Tumor necrosis factor-alpha induces differentiation of and bone resorption by osteoclasts. J Biol Chem. 275:4858–4864. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Wang MY, Shen C, An MF, Xie CQ, Wu X, Zhu QQ, Sun B, Huang YP, Zhao YL, Wang XJ and Sheng J: Combined treatment with Dendrobium candidum and black tea extract promotes osteoprotective activity in ovariectomized estrogen deficient rats and osteoclast formation. Life Sci. 220:31–41. 2018. View Article : Google Scholar

37 

Khosla S, Melton LJ III and Riggs BL: The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: Is a revision needed? J Bone Miner Res. 26:441–451. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Jensen LB, Vestergaard P, Hermann AP, Gram J, Eiken P, Abrahamsen B, Brot C, Kolthoff N, Sørensen OH, Beck-Nielsen H, et al: Hormone replacement therapy dissociates fat mass and bone mass, and tends to reduce weight gain in early postmenopausal women: A randomized controlled 5-year clinical trial of the danish osteoporosis prevention study. J Bone Miner Res. 18:333–342. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Kanis JA, Brazier JE, Stevenson M, Calvert NW and Lloyd JM: Treatment of established osteoporosis: A systematic review and cost-utility analysis. Health Technol Asses. 6:1–146. 2002. View Article : Google Scholar

40 

Tang XL, Zhu TY, Hung VW, Qin L, Wong CK, Kun EW, Tam LS and Li EK: Increased organ damage associated with deterioration in volumetric bone density and bone microarchitecture in patients with systemic lupus erythematosus on longterm glucocorticoid therapy. J Rheumatol. 39:1955–1963. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Li J, Chen C, Bi X, Zhou C, Tao H, Ni C, Yang P, Chen S, Ye M and Duan S: DNA methylation of CMTM3, SSTR2, and MDFI genes in colorectal cancer. Gene. 630:1–7. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Nakanishi R, Akiyama H, Kimura H, Otsuki B, Shimizu M, Tsuboyama T and Nakamura T: Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass. J Bone Miner Res. 23:271–277. 2010. View Article : Google Scholar

43 

Santiago JL, Alizadeh BZ, Martínez A, Espino L, de la Calle H, Fernández-Arquero M, Figueredo MA, de la Concha EG, Roep BO, Koeleman BP and Urcelay E: Study of the association between the CAPSL-IL7R locus and type 1 diabetes. Diabetologia. 51:1653–1658. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Sporeno E, Barbato G, Graziani R, Pucci P, Nitti G and Paonessa G: Production and structural characterization of amino terminally histidine tagged human oncostatin M in E. coli. Cytokine. 6:255–264. 1994. View Article : Google Scholar : PubMed/NCBI

45 

Nampei A, Hashimoto J, Hayashida K, Tsuboi H, Shi K, Tsuji I, Miyashita H, Yamada T, Matsukawa N, Matsumoto M, et al: Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone. J Bone Miner Metab. 22:176–184. 2004. View Article : Google Scholar : PubMed/NCBI

46 

Im JY, Lee KW, Won KJ, Kim BK, Ban HS, Yoon SH, Lee YJ, Kim YJ, Song KB and Won M: DNA damage-induced apoptosis suppressor (DDIAS), a novel target of NFATc1, is associated with cisplatin resistance in lung cancer. Biochim Biophys Acta. 1863:40–49. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Krishnan V, Bryant HU and MacDougald OA: Regulation of bone mass by Wnt signaling. J Clin Invest. 116:1202–1209. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Bin G, Cuifang W, Bo Z, Jing W, Jin J, Xiaoyi T, Cong C, Yonggang C, Liping A, Jinglin M and Yayi X: Fluid shear stress inhibits TNF-α-induced osteoblast apoptosis via ERK5 signaling pathway. Biochem Biophys Res Commun. 466:117–123. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Wu SS, Liang QH, Liu Y, Cui RR, Yuan LQ and Liao EY: Omentin-1 stimulates human osteoblast proliferation through PI3K/Akt signal pathway. Int J Endocrinol. 2013:3689702013. View Article : Google Scholar : PubMed/NCBI

50 

Shen C, Kim MR, Noh JM, Kim SJ, Ka SO, Kim JH, Park BH and Park JH: Erratum to: Glucocorticoid suppresses connexin 43 expression by inhibiting the Akt/mTORsignaling pathway in osteoblasts. Calcif Tissue Int. 99:982016. View Article : Google Scholar : PubMed/NCBI

51 

Li BX, Wang Y, Liu Y, Ma JX and Li YK: Altered gene expression involved in insulin signaling pathway in type II diabetic osteoporosis rats model. Endocrine. 43:136–146. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Rankin EB, Wu C, Khatri R, Wilson TL, Andersen R, Araldi E, Rankin AL, Yuan J, Kuo CJ, Schipani E and Giaccia AJ: The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell. 149:63–74. 2012. View Article : Google Scholar : PubMed/NCBI

53 

Komori T: Regulation of osteoblast differentiation by Runx2. Adv Exp Med Biol. 658:43–49. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Komori T: Roles of Runx2 in Skeletal Development. Adv Exp Med Biol. 962:83–93. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Ma Z, Zheng Y, Liu B, Bao P, Wu X, Yu C, Wen Z, Ma T, Liu J, Liu J, et al: Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation. Exp Ther Med 17: 3644-3654, 2019.
APA
Wang, Y., Ma, Z., Zheng, Y., Liu, B., Bao, P., Wu, X. ... Hu, M. (2019). Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation. Experimental and Therapeutic Medicine, 17, 3644-3654. https://doi.org/10.3892/etm.2019.7339
MLA
Wang, Y., Ma, Z., Zheng, Y., Liu, B., Bao, P., Wu, X., Yu, C., Wen, Z., Ma, T., Liu, J., Liu, C., Ma, D., Wu, H., Li, J., Yuan, Y., Lu, N., Zhao, H., Li, Y., Yang, S., Zhang, R., Dai, J., Hu, M."Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation". Experimental and Therapeutic Medicine 17.5 (2019): 3644-3654.
Chicago
Wang, Y., Ma, Z., Zheng, Y., Liu, B., Bao, P., Wu, X., Yu, C., Wen, Z., Ma, T., Liu, J., Liu, C., Ma, D., Wu, H., Li, J., Yuan, Y., Lu, N., Zhao, H., Li, Y., Yang, S., Zhang, R., Dai, J., Hu, M."Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3644-3654. https://doi.org/10.3892/etm.2019.7339
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Ma Z, Zheng Y, Liu B, Bao P, Wu X, Yu C, Wen Z, Ma T, Liu J, Liu J, et al: Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation. Exp Ther Med 17: 3644-3654, 2019.
APA
Wang, Y., Ma, Z., Zheng, Y., Liu, B., Bao, P., Wu, X. ... Hu, M. (2019). Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation. Experimental and Therapeutic Medicine, 17, 3644-3654. https://doi.org/10.3892/etm.2019.7339
MLA
Wang, Y., Ma, Z., Zheng, Y., Liu, B., Bao, P., Wu, X., Yu, C., Wen, Z., Ma, T., Liu, J., Liu, C., Ma, D., Wu, H., Li, J., Yuan, Y., Lu, N., Zhao, H., Li, Y., Yang, S., Zhang, R., Dai, J., Hu, M."Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation". Experimental and Therapeutic Medicine 17.5 (2019): 3644-3654.
Chicago
Wang, Y., Ma, Z., Zheng, Y., Liu, B., Bao, P., Wu, X., Yu, C., Wen, Z., Ma, T., Liu, J., Liu, C., Ma, D., Wu, H., Li, J., Yuan, Y., Lu, N., Zhao, H., Li, Y., Yang, S., Zhang, R., Dai, J., Hu, M."Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3644-3654. https://doi.org/10.3892/etm.2019.7339
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team