Open Access

Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation

  • Authors:
    • Yaolong Wang
    • Zhaoxia Ma
    • Yuanyuan Zheng
    • Baoling Liu
    • Pengfei Bao
    • Xingfei Wu
    • Congtao Yu
    • Zhengqi Wen
    • Tiekun Ma
    • Jinxue Liu
    • Change Liu
    • Daiping Ma
    • Haiying Wu
    • Jun Li
    • Yong Yuan
    • Ning Lu
    • Hongbin Zhao
    • Yanjiao Li
    • Suping Yang
    • Rongping Zhang
    • Jiejie Dai
    • Min Hu
  • View Affiliations

  • Published online on: March 4, 2019     https://doi.org/10.3892/etm.2019.7339
  • Pages: 3644-3654
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteoporosis (OP) treatment has always been challenging for elderly menopausal females. An animal model with a closer genetic association to human OP is essential for treatment research. Given its close genetic association to primates, the tree shrew is a suitable candidate for meeting the requirements for such an animal model. In the present study, a tree shrew OP model induced by ovariectomy (OVX), was established. Evaluation by multiple analysis methods, including blood biochemical indicators, uterus coefficients, micro‑computed tomography analysis, histochemical analysis and scanning electron microscopic observation indicated that OVX was an appropriate method to establish the OP model in tree shrews. In addition, the biomolecular characteristics of OVX‑induced osteoporosis were also assessed by transcriptome sequencing and bioinformatics analysis. The present study provides the methods used to confirm the successful establishment of the OP model in tree shrew, and suggests that the OP model is appropriate for human OP research.
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May-2019
Volume 17 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang Y, Ma Z, Zheng Y, Liu B, Bao P, Wu X, Yu C, Wen Z, Ma T, Liu J, Liu J, et al: Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation. Exp Ther Med 17: 3644-3654, 2019
APA
Wang, Y., Ma, Z., Zheng, Y., Liu, B., Bao, P., Wu, X. ... Hu, M. (2019). Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation. Experimental and Therapeutic Medicine, 17, 3644-3654. https://doi.org/10.3892/etm.2019.7339
MLA
Wang, Y., Ma, Z., Zheng, Y., Liu, B., Bao, P., Wu, X., Yu, C., Wen, Z., Ma, T., Liu, J., Liu, C., Ma, D., Wu, H., Li, J., Yuan, Y., Lu, N., Zhao, H., Li, Y., Yang, S., Zhang, R., Dai, J., Hu, M."Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation". Experimental and Therapeutic Medicine 17.5 (2019): 3644-3654.
Chicago
Wang, Y., Ma, Z., Zheng, Y., Liu, B., Bao, P., Wu, X., Yu, C., Wen, Z., Ma, T., Liu, J., Liu, C., Ma, D., Wu, H., Li, J., Yuan, Y., Lu, N., Zhao, H., Li, Y., Yang, S., Zhang, R., Dai, J., Hu, M."Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3644-3654. https://doi.org/10.3892/etm.2019.7339