Open Access

Defining the genetic profile of endometriosis (Review)

  • Authors:
    • Loukia Vassilopoulou
    • Michail Matalliotakis
    • Maria I. Zervou
    • Charoula Matalliotaki
    • Konstantinos Krithinakis
    • Ioannis Matalliotakis
    • Demetrios A. Spandidos
    • George N. Goulielmos
  • View Affiliations

  • Published online on: March 6, 2019     https://doi.org/10.3892/etm.2019.7346
  • Pages: 3267-3281
  • Copyright: © Vassilopoulou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Endometriosis is a pathological condition which has been extensively studied, since its pathophysiology stems from a broad spectrum of environmental influences and genetic factors. Familial studies aim at defining inheritance trends, while linkage analysis studies focus on the identification of genetic sites related to endometriosis susceptibility. Genetic association studies take into account candidate genes and single nucleotide polymorphisms, and hence target at unraveling the association between disease severity and genetic variation. The common goal of various types of studies is, through genetic mapping methods, the timely identification of therapeutic strategies for disease symptoms, including pelvic pain and infertility, as well as efficient counselling. While genome‑wide association studies (GWAS) play a primary role in depicting genetic contributions to disease development, they entail a certain bias as regards the case‑control nature of their design and the reproducibility of the results. Nevertheless, genetic‑oriented studies and the implementation of the results through clinical tests, hold a considerable advantage in proper disease management. In this review article, we present information about gene‑gene and gene‑environment interactions involved in endometriosis and discuss the effectiveness of GWAS in identitying novel potential therapeutic targets in an attempt to develop novel therapeutic strategies for a better management and treatment of patients with endometriosis.
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May-2019
Volume 17 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Vassilopoulou L, Matalliotakis M, Zervou MI, Matalliotaki C, Krithinakis K, Matalliotakis I, Spandidos DA and Goulielmos GN: Defining the genetic profile of endometriosis (Review). Exp Ther Med 17: 3267-3281, 2019
APA
Vassilopoulou, L., Matalliotakis, M., Zervou, M.I., Matalliotaki, C., Krithinakis, K., Matalliotakis, I. ... Goulielmos, G.N. (2019). Defining the genetic profile of endometriosis (Review). Experimental and Therapeutic Medicine, 17, 3267-3281. https://doi.org/10.3892/etm.2019.7346
MLA
Vassilopoulou, L., Matalliotakis, M., Zervou, M. I., Matalliotaki, C., Krithinakis, K., Matalliotakis, I., Spandidos, D. A., Goulielmos, G. N."Defining the genetic profile of endometriosis (Review)". Experimental and Therapeutic Medicine 17.5 (2019): 3267-3281.
Chicago
Vassilopoulou, L., Matalliotakis, M., Zervou, M. I., Matalliotaki, C., Krithinakis, K., Matalliotakis, I., Spandidos, D. A., Goulielmos, G. N."Defining the genetic profile of endometriosis (Review)". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3267-3281. https://doi.org/10.3892/etm.2019.7346