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Effects of propofol combined with remifentanil anesthesia on the NO, endothelin and inflammatory cytokines in the plasma of patients with liver cirrhosis during the perioperative period

  • Authors:
    • Yongsheng Wang
    • Rongen Qiu
    • Gaoyin Kong
    • Jitong Liu

  • View Affiliations

  • Published online on: March 8, 2019     https://doi.org/10.3892/etm.2019.7367
  • Pages: 3694-3700

  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The effects of propofol combined with remifentanil on the nitric oxide (NO), endothelin (ET-1) and inflammatory cytokines in the plasma of patients with liver cirrhosis were investigated. A retrospective analysis of 68 patients with liver cirrhosis who underwent hepatectomy in the Hunan Provincial People's Hospital from March 2016 to July 2018 was made. According to different anesthesia methods, 30 patients anesthetized with propofol were enrolled into Group A. The other 38 patients anesthetized with propofol combined with remifentanil were enrolled into Group B, and the operation time, amount of bleeding during operation and postoperative awake time of the two groups were recorded. At three separate time‑points T1 (30 min before the anesthesia), T2 (after the portal triad clamping), T3 (3 days after the operation), aspartate transaminase (AST) and alanine transaminase (ALT) levels in the plasma were measured by rate method, and the levels of NO, ET-1, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in plasma were detected by enzyme-linked immunosorbent assay (ELISA). The plasma NO levels at the T2 time-point were significantly lower than those at the T1 and T3 time-points (P<0.05); at the T2 time-point, the concentrations of AST, ALT, ET-1, IL-6 and TNF-α in the plasma in Group A were significantly higher than those of Group B (P<0.05), while the levels of plasma NO in Group A were the opposite (P<0.05). The anesthesia of propofol combined with remifentanil could contribute to the balance of NO/ET-1 and the inhibition of inflammatory factors during the hepatectomy operation in patients with liver cirrhosis, and help to protect the liver function of patients, reducing the incidence of liver ischemia-reperfusion injury in patients.
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May-2019
Volume 17 Issue 5

Print ISSN: 1792-0981
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Spandidos Publications style
Wang Y, Qiu R, Kong G and Liu J: Effects of propofol combined with remifentanil anesthesia on the NO, endothelin and inflammatory cytokines in the plasma of patients with liver cirrhosis during the perioperative period. Exp Ther Med 17: 3694-3700, 2019
APA
Wang, Y., Qiu, R., Kong, G., & Liu, J. (2019). Effects of propofol combined with remifentanil anesthesia on the NO, endothelin and inflammatory cytokines in the plasma of patients with liver cirrhosis during the perioperative period. Experimental and Therapeutic Medicine, 17, 3694-3700. https://doi.org/10.3892/etm.2019.7367
MLA
Wang, Y., Qiu, R., Kong, G., Liu, J."Effects of propofol combined with remifentanil anesthesia on the NO, endothelin and inflammatory cytokines in the plasma of patients with liver cirrhosis during the perioperative period". Experimental and Therapeutic Medicine 17.5 (2019): 3694-3700.
Chicago
Wang, Y., Qiu, R., Kong, G., Liu, J."Effects of propofol combined with remifentanil anesthesia on the NO, endothelin and inflammatory cytokines in the plasma of patients with liver cirrhosis during the perioperative period". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3694-3700. https://doi.org/10.3892/etm.2019.7367