Anticancer activity of bergenin against cervical cancer cells involves apoptosis, cell cycle arrest, inhibition of cell migration and the STAT3 signalling pathway Retraction in /10.3892/etm.2021.10085

Shi,Xingyuan; Xu,Manman; Luo,Kai; Huang,Wenjin; Yu,Hongwei; Zhou,Tongchong

doi:10.3892/etm.2019.7380

May-2019 Volume 17 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

May-2019 Volume 17 Issue 5

Full Size Image

Article Open Access

Anticancer activity of bergenin against cervical cancer cells involves apoptosis, cell cycle arrest, inhibition of cell migration and the STAT3 signalling pathway

Retraction in: /10.3892/etm.2021.10085

Authors:
- Xingyuan Shi
- Manman Xu
- Kai Luo
- Wenjin Huang
- Hongwei Yu
- Tongchong Zhou
View Affiliations / Copyright

Affiliations: Department of Radiation Oncology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China, Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510000, P.R. China, The Research Institute, Cancer Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China

Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 3525-3529
|
Published online on: March 13, 2019

https://doi.org/10.3892/etm.2019.7380
Expand metrics +

Abstract

Bergenin is a secondary metabolite that may be primarily isolated from Bergenia species. Although it has been found to exhibit significant biological activities, the anticancer activity of bergenin against cervical cancer cells has not been explored. The present study was designed to evaluate the anticancer effects of bergenin on HeLa cervical cancer cells. The results showed that bergenin reduced the cell viability of the HeLa cervical cancer cells in a dose‑dependent pattern. However, the anticancer effects of bergenin were found to be comparatively lower on the normal cervical cells. Furthermore, the anticancer effects of bergenin were primarily found to be due to induction of apoptosis in the HeLa cervical cancer cells. Notably, bergenin also enhanced the expression of Bax and decreased the expression of Bcl‑2. WThe effect of bergenin on cell cycle phase distribution of HeLa cells was also investigated and it was found that bergenin could induce G0/G1 cell cycle arrest. Furthermore, bergenin could also inhibit the migration of HeLa cancer cells as well as the phosphorylation of STAT3. Taken together, bergenin may be a promising candidate for the management of cervical cancer.

View Figures

View References

1	Brinton LA: Epidemiology of cervical cancer-overview. IARC Sci Publ. 3–23. 1992.PubMed/NCBI
2	Franco EL, Duarte-Franco E and Ferenczy A: Cervical cancer: Epidemiology, prevention and the role of human papillomavirus infection. CMAJ. 164:1017–1025. 2001.PubMed/NCBI
3	Smith JS, Lindsay L, Hoots B, Keys J, Franceschi S, Winer R and Clifford GM: Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: A meta-analysis update. Int J Cancer. 121:621–632. 2007. View Article : Google Scholar : PubMed/NCBI
4	Lan-ju JI: Bergenin HPLC determination of two species of bergenia growing in tibet. Acta Botanica Boreali-occidentalia Sinica. 2:312005.
5	Singh DP, Srivastava SK, Govindarajan R and Rawat AKS: High-performance liquid chromatographic determination of bergenin in different Bergenia species. Acta Chromatographica. 19:246–252. 2007.
6	Gao X, Wang Y, Zhang J, Lin L, Yao Q and Xiang G: Bergenin suppresses the growth of colorectal cancer cells by inhibiting PI3K/AKT/mTOR signaling pathway. Trop J Pharm Res. 16:2307–2313. 2017.
7	Yu H, Pardoll D and Jove R: STATs in cancer inflammation and immunity: A leading role for STAT3. Nat Rev Cancer. 9:798–809. 2009. View Article : Google Scholar : PubMed/NCBI
8	Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI
9	Patel S, Gheewala N, Suthar A and Shah A: In-vitro cytotoxicity activity of Solanum nigrum extract against Hela cell line and Vero cell line. Int J Pharm Pharmaceutic Sci. 1:38–46. 2009.
10	Kini S and Swain SP: Synthesis and evaluation of novel benzothiazole derivatives against human cervical cancer cell lines. Indian J Pharm Sci. 69:462007. View Article : Google Scholar
11	Aadil K, Rather MA and Rashid R: Plant-based natural compounds and herbal extracts as promising apoptotic agents: Their implications for cancer prevention and treatment Adv. Biomed Pharma. 3:245–269. 2016.
12	Fisher DE: Apoptosis in cancer therapy: Crossing the threshold. Cell. 78:539–542. 1994. View Article : Google Scholar : PubMed/NCBI
13	Evan GI and Vousden KH: Proliferation, cell cycle and apoptosis in cancer. Nature. 411:342–348. 2001. View Article : Google Scholar : PubMed/NCBI
14	Waldman T, Zhang Y, Dillehay L, Yu J, Kinzler K, Vogelstein B and Williams J: Cell-cycle arrest versus cell death in cancer therapy. Nat Med. 3:1034–1036. 1997. View Article : Google Scholar : PubMed/NCBI
15	Jones DH, Nakashima T, Sanchez OH, Kozieradzki I, Komarova SV, Sarosi I, Morony S, Rubin E, Sarao R, Hojilla CV and Komnenovic V: Regulation of cancer cell migration and bone metastasis by RANKL Nature 440. 692–346. 2006.
16	Yu H, Lee H, Herrmann A, Buettner R and Jove R: Revisiting STAT3 signalling in cancer: New and unexpected biological functions. Nat Rev Cancer. 14:736–746. 2014. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Anticancer activity of bergenin against cervical cancer cells involves apoptosis, cell cycle arrest, inhibition of cell migration and the STAT3 signalling pathway

Retraction in: /10.3892/etm.2021.10085

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Related Articles