Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and c‑reactive protein in the serum of patients with pregnancy‑induced hypertension syndrome

Ma,Li; Li,Liang; Han,Ping; Meng,Fanchun; Jiao,Chunhong; Zhang,Hongmei

doi:10.3892/etm.2019.7385

Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and c‑reactive protein in the serum of patients with pregnancy‑induced hypertension syndrome

Authors:
- Li Ma
- Liang Li
- Ping Han
- Fanchun Meng
- Chunhong Jiao
- Hongmei Zhang
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Affiliations: Department of Obstetrics, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China, Department of Pharmacy, Yidu Central Hospital of Weifang, Weifang, Shandong 262500, P.R. China, Department of Respiratory Medicine, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Obstetric Delivery Room, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Rehabilitation, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Ward 1, Department of Gynecology, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China
Published online on: March 13, 2019 https://doi.org/10.3892/etm.2019.7385
Pages: 3682-3688
Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Effect and clinical efficacy of magnesium sulfate combined with phentolamine on homocysteine and C‑reactive protein in the serum of patients with pregnancy‑induced hypertension syndrome were investigated. A total of 96 patients with pregnancy‑induced hypertension syndrome who were diagnosed and treated in Jining No. 1 People's Hospital from February 2016 to January 2018 were retrospectively analyzed. The patients were grouped according to the dosage regimen. The patients who received the combination treatment of magnesium sulfate and phentolamine on the basis of magnesium sulfate were included in the observation group, and the patients who were treated with the intravenous infusion of magnesium sulfate alone were included in the control group. Mean arterial pressure (MAP), the content of 24 h urine protein, systolic blood pressure (SBP), diastolic blood pressure (DBP), Hcy, and CRP of the pregnant women were observed. MAP and the content of 24 h urine protein, SBP and DBP of the patients in the observation group after the treatment were significantly lower than those of the patients in the control group (P<0.001). Hcy and CRP of the patients in the observation group after the treatment were significantly lower than those of the patients in the control group (P<0.001). The total effective rate of the patients in the observation group was significantly higher than that of the patients in the control group (P<0.05). In conclusion, the meliorative effect of magnesium sulphate combined with phentolamine on the level of MAP, the content of 24 h urine protein, SBP, DBP, Hcy and CRP in pregnant woman had a greater impact than that of the single use of the intravenous infusion of magnesium sulfate in the treatment of pregnancy‑induced hypertension syndrome, and the clinical efficacy of magnesium sulphate combined with phentolamine was better, thus worthwhile to promote widely in clinic.

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