Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2019 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2019 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and c‑reactive protein in the serum of patients with pregnancy‑induced hypertension syndrome

  • Authors:
    • Li Ma
    • Liang Li
    • Ping Han
    • Fanchun Meng
    • Chunhong Jiao
    • Hongmei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China, Department of Pharmacy, Yidu Central Hospital of Weifang, Weifang, Shandong 262500, P.R. China, Department of Respiratory Medicine, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Obstetric Delivery Room, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Rehabilitation, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Ward 1, Department of Gynecology, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3682-3688
    |
    Published online on: March 13, 2019
       https://doi.org/10.3892/etm.2019.7385
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Effect and clinical efficacy of magnesium sulfate combined with phentolamine on homocysteine and C‑reactive protein in the serum of patients with pregnancy‑induced hypertension syndrome were investigated. A total of 96 patients with pregnancy‑induced hypertension syndrome who were diagnosed and treated in Jining No. 1 People's Hospital from February 2016 to January 2018 were retrospectively analyzed. The patients were grouped according to the dosage regimen. The patients who received the combination treatment of magnesium sulfate and phentolamine on the basis of magnesium sulfate were included in the observation group, and the patients who were treated with the intravenous infusion of magnesium sulfate alone were included in the control group. Mean arterial pressure (MAP), the content of 24 h urine protein, systolic blood pressure (SBP), diastolic blood pressure (DBP), Hcy, and CRP of the pregnant women were observed. MAP and the content of 24 h urine protein, SBP and DBP of the patients in the observation group after the treatment were significantly lower than those of the patients in the control group (P<0.001). Hcy and CRP of the patients in the observation group after the treatment were significantly lower than those of the patients in the control group (P<0.001). The total effective rate of the patients in the observation group was significantly higher than that of the patients in the control group (P<0.05). In conclusion, the meliorative effect of magnesium sulphate combined with phentolamine on the level of MAP, the content of 24 h urine protein, SBP, DBP, Hcy and CRP in pregnant woman had a greater impact than that of the single use of the intravenous infusion of magnesium sulfate in the treatment of pregnancy‑induced hypertension syndrome, and the clinical efficacy of magnesium sulphate combined with phentolamine was better, thus worthwhile to promote widely in clinic.
View Figures

Figure 1

Figure 2

View References

1 

Zhou A, Xiong C, Hu R, Zhang Y, Bassig BA, Triche E, Yang S, Qiu L, Zhang Y, Yao C, et al: Pre-pregnancy BMI, gestational weight gain, and the risk of hypertensive disorders of pregnancy: a cohort study in Wuhan, China. PLoS One. 10:e01362912015. View Article : Google Scholar : PubMed/NCBI

2 

Zeng L, Yang K and Ge J: Uncovering the pharmacological mechanism of astragalus salvia compound on pregnancy-induced hypertension syndrome by a network pharmacology approach. Sci Rep. 7:168492017. View Article : Google Scholar : PubMed/NCBI

3 

Ankichetty SP, Chin KJ, Chan VW, Sahajanandan R, Tan H, Grewal A and Perlas A: Regional anesthesia in patients with pregnancy induced hypertension. J Anaesthesiol Clin Pharmacol. 29:435–444. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Sato T and Takeuchi M: Pregnancy-induced hypertension-related chorioretinitis resembling uveal effusion syndrome: a case report. Medicine (Baltimore). 97:e115722018. View Article : Google Scholar : PubMed/NCBI

5 

Jia JP, Wu YX and Xie GH: Clinical observation on treatment of albuminuria in patients with pregnancy-induced hypertension syndrome in puerperium by Xiaobai Decoction. Zhongguo Zhong Xi Yi Jie He Za Zhi. 27:644–646. 2007.(In Chinese). PubMed/NCBI

6 

Fang MR and Li JC: Evaluation of the efficacy of ligustrazine collaborated with magnesium sulfate in the treatment of pregnancy-induced hypertension in rats. Shi Yan Sheng Wu Xue Bao. 38:45–53. 2005.(In Chinese). PubMed/NCBI

7 

Wang L, Liu ZQ, Huo YQ, Yao LJ, Wei XG and Wang YF: Change of hs-CRP, sVCAM-1, NT-proBNP levels in patients with pregnancy-induced hypertension after therapy with magnesium sulfate and nifedipine. Asian Pac J Trop Med. 6:897–901. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Pan L, Liu C, Kong Y, Piao Z and Cheng B: Phentolamine inhibits angiogenesis in vitro: suppression of proliferation migration and differentiation of human endothelial cells. Clin Hemorheol Microcirc. 65:31–41. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Burton TJ and Wilkinson IB: The dangers of immediate-release nifedipine in the emergency treatment of hypertension. J Hum Hypertens. 22:301–302. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Folic MM, Jankovic SM, Varjacic MR and Folic MD: Effects of methyldopa and nifedipine on uteroplacental and fetal hemodynamics in gestational hypertension. Hypertens Pregnancy. 31:31–39. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Lungeanu-Juravle L, Patrascu N, Deleanu OC and Cinteza M: The role of obstructive sleep apnea in developing gestational hypertension and preeclampsia. Maedica (Buchar). 11:330–333. 2016.PubMed/NCBI

12 

Uguz F: Is there any association between use of antidepressants and preeclampsia or gestational hypertension?: a systematic review of current studies. J Clin Psychopharmacol. 37:72–77. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Tsai HM and Kuo E: From gestational hypertension and preeclampsia to atypical hemolytic uremic syndrome. Obstet Gynecol. 127:907–910. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Tinsley JH, Chiasson VL, South S, Mahajan A and Mitchell BM: Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension. Am J Hypertens. 22:1107–1114. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Tuuri AL, Jauhiainen MS, Tikkanen MJ and Kaaja RJ: Systolic blood pressure and fatty acid-binding protein 4 predict pregnancy-induced hypertension in overweight nulliparous women. Placenta. 35:797–801. 2014. View Article : Google Scholar : PubMed/NCBI

16 

van Middendorp D, ten Asbroek A, Bio FY, Edusei A, Meijjer L, Newton S and Agyemang C: Rural and urban differences in blood pressure and pregnancy-induced hypertension among pregnant women in Ghana. Global Health. 9:592013. View Article : Google Scholar : PubMed/NCBI

17 

Pan A, Wang Y, Yuan JM and Koh WP: High-sensitive C-reactive protein and risk of incident type 2 diabetes: A case-control study nested within the Singapore Chinese Health Study. BMC Endocr Disord. 17:82017. View Article : Google Scholar : PubMed/NCBI

18 

Li S, Tang X, Peng L, Luo Y, Zhao Y, Chen L, Dong R, Zhu J, Chen Y and Liu J: A head-to-head comparison of homocysteine and cystatin C as pre-procedure predictors for contrast-induced nephropathy in patients undergoing coronary computed tomography angiography. Clin Chim Acta. 444:86–91. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Liu F, Yang H, Li G, Zou K and Chen Y: Effect of a small dose of aspirin on quantitative test of 24-h urinary protein in patients with hypertension in pregnancy. Exp Ther Med. 13:37–40. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Gangaram R, Ojwang PJ, Moodley J and Maharaj D: The accuracy of urine dipsticks as a screening test for proteinuria in hypertensive disorders of pregnancy. Hypertens Pregnancy. 24:117–123. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Nzelu D, Yeung F, Couderq D, Shennan A and Kametas NA: An inaccurate automated device negatively impacts the diagnosis and treatment of gestational hypertension. Pregnancy Hypertens. 10:28–33. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Shekelle P: Lowering homocysteine with folic acid and B vitamins did not prevent vascular events after myocardial infarction. Evid Based Med. 11:1052006. View Article : Google Scholar : PubMed/NCBI

23 

Mitaki S, Nagai A, Oguro H and Yamaguchi S: C-reactive protein levels are associated with cerebral small vessel-related lesions. Acta Neurol Scand. 133:68–74. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Bánhidy F, Acs N, Puhó EH and Czeizel AE: The efficacy of antihypertensive treatment in pregnant women with chronic and gestational hypertension: a population-based study. Hypertens Res. 33:460–466. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ma L, Li L, Han P, Meng F, Jiao C and Zhang H: Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and c‑reactive protein in the serum of patients with pregnancy‑induced hypertension syndrome. Exp Ther Med 17: 3682-3688, 2019.
APA
Ma, L., Li, L., Han, P., Meng, F., Jiao, C., & Zhang, H. (2019). Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and c‑reactive protein in the serum of patients with pregnancy‑induced hypertension syndrome. Experimental and Therapeutic Medicine, 17, 3682-3688. https://doi.org/10.3892/etm.2019.7385
MLA
Ma, L., Li, L., Han, P., Meng, F., Jiao, C., Zhang, H."Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and c‑reactive protein in the serum of patients with pregnancy‑induced hypertension syndrome". Experimental and Therapeutic Medicine 17.5 (2019): 3682-3688.
Chicago
Ma, L., Li, L., Han, P., Meng, F., Jiao, C., Zhang, H."Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and c‑reactive protein in the serum of patients with pregnancy‑induced hypertension syndrome". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3682-3688. https://doi.org/10.3892/etm.2019.7385
Copy and paste a formatted citation
x
Spandidos Publications style
Ma L, Li L, Han P, Meng F, Jiao C and Zhang H: Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and c‑reactive protein in the serum of patients with pregnancy‑induced hypertension syndrome. Exp Ther Med 17: 3682-3688, 2019.
APA
Ma, L., Li, L., Han, P., Meng, F., Jiao, C., & Zhang, H. (2019). Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and c‑reactive protein in the serum of patients with pregnancy‑induced hypertension syndrome. Experimental and Therapeutic Medicine, 17, 3682-3688. https://doi.org/10.3892/etm.2019.7385
MLA
Ma, L., Li, L., Han, P., Meng, F., Jiao, C., Zhang, H."Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and c‑reactive protein in the serum of patients with pregnancy‑induced hypertension syndrome". Experimental and Therapeutic Medicine 17.5 (2019): 3682-3688.
Chicago
Ma, L., Li, L., Han, P., Meng, F., Jiao, C., Zhang, H."Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and c‑reactive protein in the serum of patients with pregnancy‑induced hypertension syndrome". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3682-3688. https://doi.org/10.3892/etm.2019.7385
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team