Correlation between angiopoietin-like proteins in inflammatory mediators in peripheral blood and severity of coronary arterial lesion in patients with acute myocardial infarction

Cao,Yuejuan; Li,Rongqing; Zhang,Fengping; Guo,Zhaozeng; Tuo,Shaoyong; Li,Yuming

doi:10.3892/etm.2019.7386

Correlation between angiopoietin-like proteins in inflammatory mediators in peripheral blood and severity of coronary arterial lesion in patients with acute myocardial infarction

Authors:
- Yuejuan Cao
- Rongqing Li
- Fengping Zhang
- Zhaozeng Guo
- Shaoyong Tuo
- Yuming Li
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Affiliations: Department of Cardiology, Tianjin Union Medical Center, Tianjin 300121, P.R. China, Department of Vascular Surgery, Tianjin Union Medical Center, Tianjin 300121, P.R. China, Department of Radiology, Pingjin Hospital Heart Center and Tianjin, Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Logistics University of PAPF, Tianjin 300162, P.R. China
Published online on: March 13, 2019 https://doi.org/10.3892/etm.2019.7386
Pages: 3495-3500
Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The effects of angiopoietin-like protein 2 (Angptl 2) and interleukin-6 (IL-6) in inflammatory mediators on the severity of coronary arterial lesion in patients with acute myocardial infarction were investigated. One hundred and twenty-six patients with acute myocardial infarction admitted to Tianjin Union Medical Center (the myocardial infarction group) and 133 healthy individuals (the control group) were selected for retrospective analysis from January 2013 to December 2015. The levels of Angptl 2 and IL-6 in serum of patients were detected by enzyme linked immunosorbent assay (ELISA), and the correlation analysis between the levels and the degree of coronary stenosis in patients with myocardial infarction was conducted. The expression level of Angptl 2 and IL-6 in the myocardial infarction group was significantly higher than that in the control group P<0.001. In the myocardial infarction group, the expression levels of Angptl 2 and IL-6 were the highest in the patients with severe stenosis, followed by the moderate stenosis, and the lowest in the patients with mild stenosis (P<0.050). Pearson's correlation analysis showed that Angptl 2 and IL-6 were positively correlated with the diameter of coronary stenosis (r=0.696, 0.750, P<0.001). In conclusion, both Angptl 2 and IL-6 are highly expressed in the peripheral blood of patients with acute myocardial infarction and involved in the occurrence and development of the disease. Moreover, Angptl2 and IL-6 are positively correlated with the severity of coronary arterial lesion in patients with acute myocardial infarction, and they are expected to become a target for the diagnosis and treatment of coronary atherosclerosis (CA) in the future.

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