Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2019 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2019 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Silk fibroin/poly(L‑lactic acid‑co‑ε‑caprolactone) electrospun nanofibrous scaffolds exert a protective effect following myocardial infarction

  • Authors:
    • Mingjun Du
    • Jianmin Gu
    • Juan Wang
    • Yizheng Xue
    • Yiwen Ma
    • Xiumei Mo
    • Song Xue
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, P.R. China, College of Clinical Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, P.R. China, Department of Anesthesiology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, P.R. China
    Copyright: © Du et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3989-3998
    |
    Published online on: March 18, 2019
       https://doi.org/10.3892/etm.2019.7405
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Electrospinning using biocompatible polymer scaffolds, seeded with or without stem cells, is considered a promising technique for producing fibrous scaffolds with therapeutic possibilities for ischemic heart disease. However, no optimal scaffolds for treating ischemic heart disease have been identified thus far. In the present study, it was evaluated whether electrospun silk fibroin (SF)‑blended poly(L‑lactic acid‑co‑ε‑caprolactone) [P(LLA‑CL)] scaffolds that were seeded with cluster of differentiation 117 (c‑kit)+ bone marrow (BM) cells may serve a protective role in cardiac remodeling following myocardial infarction (MI). Mechanical characteristics and cytocompatibility were compared between SF/P(LLA‑CL) and P(LLA‑CL) electrospun nanofibrous scaffolds in vitro. It was observed that MI led to a significant increase of the c‑kit+ BM cell subpopulation in mice. Magnetic activated cell sorting was performed to harvest the c‑kit+ cell population from the BM of mice following MI. c‑kit+ BM cells were seeded on SF/P(LLA‑CL) and P(LLA‑CL) electrospun nanofibrous scaffolds. Results indicated that SF/P(LLA‑CL) electrospun nanofibrous scaffolds were superior to P(LLA‑CL) electrospun nanofibrous scaffolds in improving c‑kit+ BM cell proliferation. Additionally, compared with pure SF/P(LLA‑CL) electrospun nanofibrous scaffolds, SF/P(LLA‑CL) scaffolds seeded with c‑kit+ BM cells resulted in lower levels of MI markers and reduced infarct size, leading to greater global heart function improvement in vivo. The findings of the present study indicated that SF/P(LLA‑CL) electrospun nanofibrous scaffolds seeded with c‑kit+ BM cells exert a protective effect against MI and may be a promising approach for cardiac regeneration after ischemic heart disease.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Du M, Schmull S, Zhang W, Wang C, Lian F, Chen Y and Xue S: c-kit(+)AT2R(+) bone marrow mononuclear cell subset is a superior subset for cardiac protection after myocardial infarction. Stem Cells Int. 2016:49135152016. View Article : Google Scholar : PubMed/NCBI

2 

Duran JM, Makarewich CA, Sharp TE, Starosta T, Zhu F, Hoffman NE, Chiba Y, Madesh M, Berretta RM, Kubo H and Houser SR: Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms. Circ Res. 113:539–552. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Jessup M and Brozena S: Heart failure. N Engl J Med. 348:2007–2018. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Lehtinen M, Pätilä T, Kankuri E, Lauerma K, Sinisalo J, Laine M, Kupari M, Vento A and Harjula A; Helsinki BMMC Collaboration, : Intramyocardial bone marrow mononuclear cell transplantation in ischemic heart failure: Long-term follow-up. J Heart Lung Transplant. 34:899–905. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Gude NA and Sussman MA: Chasing c-Kit through the heart: Taking a broader view. Pharmacol Res. 127:110–115. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Lagostena L, Avitabile D, De Falco E, Orlandi A, Grassi F, Iachininoto MG, Ragone G, Fucile S, Pompilio G, Eusebi F, et al: Electrophysiological properties of mouse bone marrow c-kit+ cells co-cultured onto neonatal cardiac myocytes. Cardiovasc Res. 66:482–492. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Liu J, Wu P, Wang H, Wang Y, Du Y, Cheng W, Xu Z, Zhou N, Wang L and Yang Z: Necroptosis induced by Ad-HGF activates endogenous C-Kit+ cardiac stem cells and promotes cardiomyocyte proliferation and angiogenesis in the infarcted aged heart. Cell Physiol Biochem. 40:847–860. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Awada HK, Long DW, Wang Z, Hwang MP, Kim K and Wang Y: A single injection of protein-loaded coacervate-gel significantly improves cardiac function post infarction. Biomaterials. 125:65–80. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Kai D, Prabhakaran MP, Jin G and Ramakrishna S: Polypyrrole-contained electrospun conductive nanofibrous membranes for cardiac tissue engineering. J Biomed Mater Res A. 99:376–385. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Godier-Furnemont AF, Martens TP, Koeckert MS, Wan L, Parks J, Arai K, Zhang G, Hudson B, Homma S and Vunjak-Novakovic G: Composite scaffold provides a cell delivery platform for cardiovascular repair. Proc Natl Acad Sci USA. 108:7974–7979. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Dhand C, Ong ST, Dwivedi N, Diaz SM, Venugopal JR, Navaneethan B, Fazil MH, Liu S, Seitz V, Wintermantel E, et al: Bio-inspired in situ crosslinking and mineralization of electrospun collagen scaffolds for bone tissue engineering. Biomaterials. 104:323–338. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Mo Y, Guo R, Zhang Y, Xue W and Cheng B: Controlled dual delivery of angiogenin and curcumin by electrospun nanofibers for skin regeneration. Tissue Eng Part A. 27:2017.

13 

Prabhakaran MP, Kai D, Ghasemi-Mobarakeh L and Ramakrishna S: Electrospun biocomposite nanofibrous patch for cardiac tissue engineering. Biomed Mater. 6:1748–6041. 2011. View Article : Google Scholar

14 

Kai D, Prabhakaran MP, Jin G and Ramakrishna S: Guided orientation of cardiomyocytes on electrospun aligned nanofibers for cardiac tissue engineering. J Biomed Mater Res B Appl Biomater. 98:379–386. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Wang Z, Lin M, Xie Q, Sun H, Huang Y, Zhang D, Yu Z, Bi X, Chen J, Wang J, et al: Electrospun silk fibroin/poly(lactide-co-epsilon-caprolactone) nanofibrous scaffolds for bone regeneration. Int J Nanomedicine. 11:1483–1500. 2016.PubMed/NCBI

16 

Zhang D, Ni N, Chen J, Yao Q, Shen B, Zhang Y, Zhu M, Wang Z, Ruan J, Wang J, et al: Electrospun SF/PLCL nanofibrous membrane: A potential scaffold for retinal progenitor cell proliferation and differentiation. Sci Rep. 5:143262015. View Article : Google Scholar : PubMed/NCBI

17 

Wang CY, Zhang KH, Fan CY, Mo XM, Ruan HJ and Li FF: Aligned natural-synthetic polyblend nanofibers for peripheral nerve regeneration. Acta Biomater. 7:634–643. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Chen J, Yan C, Zhu M, Yao Q, Shao C, Lu W, Wang J, Mo X, Gu P, Fu Y and Fan X: Electrospun nanofibrous SF/P(LLA-CL) membrane: A potential substratum for endothelial keratoplasty. Int J Nanomedicine. 10:3337–3350. 2015.PubMed/NCBI

19 

Xiang P, Wu KC, Zhu Y, Xiang L, Li C, Chen DL, Chen F, Xu G, Wang A, Li M and Jin ZB: A novel Bruch's membrane-mimetic electrospun substrate scaffold for human retinal pigment epithelium cells. Biomaterials. 35:9777–9788. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Zhang K, Mo X, Huang C, He C and Wang H: Electrospun scaffolds from silk fibroin and their cellular compatibility. J Biomed Mater Res A. 93:976–983. 2010.PubMed/NCBI

21 

Kuihua Z, Chunyang W, Cunyi F and Xiumei M: Aligned SF/P(LLA-CL)-blended nanofibers encapsulating nerve growth factor for peripheral nerve regeneration. J Biomed Mater Res A. 102:2680–2691. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Zhang K, Wang H, Huang C, Su Y, Mo X and Ikada Y: Fabrication of silk fibroin blended P(LLA-CL) nanofibrous scaffolds for tissue engineering. J Biomed Mater Res A. 93:984–993. 2010.PubMed/NCBI

23 

Aznar-Cervantes S, Pagán A, Martínez JG, Bernabeu-Esclapez A, Otero TF, Meseguer-Olmo L, Paredes JI and Cenis JL: Electrospun silk fibroin scaffolds coated with reduced graphene promote neurite outgrowth of PC-12 cells under electrical stimulation. Mater Sci Eng C Mater Biol Appl. 79:315–325. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Du J, Zhang L, Wang Z, Yano N, Zhao YT, Wei L, Dubielecka-Szczerba P, Liu PY, Zhuang S, Qin G and Zhao TC: Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted hearts. Am J Physiol Cell Physiol. 310:C270–C283. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Brooks AC, DeMartino AM, Brainard RE, Brittian KR, Bhatnagar A and Jones SP: Induction of activating transcription factor 3 limits survival following infarct-induced heart failure in mice. Am J Physiol Heart Circ Physiol. 309:H1326–H1335. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Nishikido T, Oyama J, Shiraki A, Komoda H and Node K: Deletion of apoptosis inhibitor of macrophage (AIM)/CD5L attenuates the inflammatory response and infarct size in acute myocardial infarction. J Am Heart Assoc. 5:0028632016. View Article : Google Scholar

27 

Hu X, Huang X, Yang Q, Wang L, Sun J, Zhan H, Lin J, Pu Z, Jiang J, Sun Y, et al: Safety and efficacy of intracoronary hypoxia-preconditioned bone marrow mononuclear cell administration for acute myocardial infarction patients: The CHINA-AMI randomized controlled trial. Int J Cardiol. 184:446–451. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Bao L, Meng Q, Li Y, Deng S, Yu Z, Liu Z, Zhang L and Fan H: C-Kit positive cardiac stem cells and bone marrow-derived mesenchymal stem cells synergistically enhance angiogenesis and improve cardiac function after myocardial infarction in a paracrine manner. J Card Fail. 23:403–415. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Fazel S, Cimini M, Chen L, Li S, Angoulvant D, Fedak P, Verma S, Weisel RD, Keating A and Li RK: Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest. 116:1865–1877. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Yao Q, Cosme JG, Xu T, Miszuk JM, Picciani PH, Fong H and Sun H: Three dimensional electrospun PCL/PLA blend nanofibrous scaffolds with significantly improved stem cells osteogenic differentiation and cranial bone formation. Biomaterials. 115:115–127. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Li H, Wu T, Zheng Y, El-Hamshary H, Al-Deyab SS and Mo X: Fabrication and characterization of Mg/P(LLA-CL)-blended nanofiber scaffold. J Biomater Sci Polym Ed. 25:1013–1027. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Zhang K, Fu Q, Yoo J, Chen X, Chandra P, Mo X, Song L, Atala A and Zhao W: 3D bioprinting of urethra with PCL/PLCL blend and dual autologous cells in fibrin hydrogel: An in vitro evaluation of biomimetic mechanical property and cell growth environment. Acta Biomater. 50:154–164. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Fluke LM, Restrepo RD, Patel S, Hoagland BD, Krevetski LM and Stephenson JT: Strength and histology of a nanofiber scaffold in rats. J Surg Res. 205:432–439. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Johari N, Madaah Hosseini HR and Samadikuchaksaraei A: Optimized composition of nanocomposite scaffolds formed from silk fibroin and nano-TiO2 for bone tissue engineering. Mater Sci Eng C Mater Biol Appl. 79:783–792. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Naskar D, Ghosh AK, Mandal M, Das P, Nandi SK and Kundu SC: Dual growth factor loaded nonmulberry silk fibroin/carbon nanofiber composite 3D scaffolds for in vitro and in vivo bone regeneration. Biomaterials. 136:67–85. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Yin A, Luo R, Li J, Mo X, Wang Y and Zhang X: Coaxial electrospinning multicomponent functional controlled-release vascular graft: Optimization of graft properties. Colloids Surf B Biointerfaces. 152:432–439. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Liu Y, Xu Y, Wang Z, Wen D, Zhang W, Schmull S, Li H, Chen Y and Xue S: Electrospun nanofibrous sheets of collagen/elastin/polycaprolactone improve cardiac repair after myocardial infarction. Am J Transl Res. 8:1678–1694. 2016.PubMed/NCBI

38 

Kai D, Wang QL, Wang HJ, Prabhakaran MP, Zhang Y, Tan YZ and Ramakrishna S: Stem cell-loaded nanofibrous patch promotes the regeneration of infarcted myocardium with functional improvement in rat model. Acta Biomater. 10:2727–2738. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Stevens KR, Kreutziger KL, Dupras SK, Korte FS, Regnier M, Muskheli V, Nourse MB, Bendixen K, Reinecke H and Murry CE: Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue. Proc Natl Acad Sci USA. 106:16568–16573. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K, et al: Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 114:763–776. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Hao H, Hu S, Chen H, Bu D, Zhu L, Xu C, Chu F, Huo X, Tang Y, Sun X, et al: Loss of endothelial CXCR7 impairs vascular homeostasis and cardiac remodeling after myocardial infarction: Implications for cardiovascular drug discovery. Circulation. 135:1253–1264. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Pinet F, Cuvelliez M, Kelder T, Amouyel P, Radonjic M and Bauters C: Integrative network analysis reveals time-dependent molecular events underlying left ventricular remodeling in post-myocardial infarction patients. Biochim Biophys Acta Mol Basis Dis. 1863:1445–1453. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Olivier A, Girerd N, Michel JB, Ketelslegers JM, Fay R, Vincent J, Bramlage P, Pitt B, Zannad F and Rossignol P; EPHESUS Investigators, : Combined baseline and one-month changes in big endothelin-1 and brain natriuretic peptide plasma concentrations predict clinical outcomes in patients with left ventricular dysfunction after acute myocardial infarction: Insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) study. Int J Cardiol. 241:344–350. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Frey A, Saxon VM, Popp S, Lehmann M, Mathes D, Pachel C, Hofmann U, Ertl G, Lesch KP and Frantz S: Early citalopram treatment increases mortality due to left ventricular rupture in mice after myocardial infarction. J Mol Cell Cardiol. 98:28–36. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Du M, Gu J, Wang J, Xue Y, Ma Y, Mo X and Xue S: Silk fibroin/poly(L‑lactic acid‑co‑ε‑caprolactone) electrospun nanofibrous scaffolds exert a protective effect following myocardial infarction. Exp Ther Med 17: 3989-3998, 2019.
APA
Du, M., Gu, J., Wang, J., Xue, Y., Ma, Y., Mo, X., & Xue, S. (2019). Silk fibroin/poly(L‑lactic acid‑co‑ε‑caprolactone) electrospun nanofibrous scaffolds exert a protective effect following myocardial infarction. Experimental and Therapeutic Medicine, 17, 3989-3998. https://doi.org/10.3892/etm.2019.7405
MLA
Du, M., Gu, J., Wang, J., Xue, Y., Ma, Y., Mo, X., Xue, S."Silk fibroin/poly(L‑lactic acid‑co‑ε‑caprolactone) electrospun nanofibrous scaffolds exert a protective effect following myocardial infarction". Experimental and Therapeutic Medicine 17.5 (2019): 3989-3998.
Chicago
Du, M., Gu, J., Wang, J., Xue, Y., Ma, Y., Mo, X., Xue, S."Silk fibroin/poly(L‑lactic acid‑co‑ε‑caprolactone) electrospun nanofibrous scaffolds exert a protective effect following myocardial infarction". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3989-3998. https://doi.org/10.3892/etm.2019.7405
Copy and paste a formatted citation
x
Spandidos Publications style
Du M, Gu J, Wang J, Xue Y, Ma Y, Mo X and Xue S: Silk fibroin/poly(L‑lactic acid‑co‑ε‑caprolactone) electrospun nanofibrous scaffolds exert a protective effect following myocardial infarction. Exp Ther Med 17: 3989-3998, 2019.
APA
Du, M., Gu, J., Wang, J., Xue, Y., Ma, Y., Mo, X., & Xue, S. (2019). Silk fibroin/poly(L‑lactic acid‑co‑ε‑caprolactone) electrospun nanofibrous scaffolds exert a protective effect following myocardial infarction. Experimental and Therapeutic Medicine, 17, 3989-3998. https://doi.org/10.3892/etm.2019.7405
MLA
Du, M., Gu, J., Wang, J., Xue, Y., Ma, Y., Mo, X., Xue, S."Silk fibroin/poly(L‑lactic acid‑co‑ε‑caprolactone) electrospun nanofibrous scaffolds exert a protective effect following myocardial infarction". Experimental and Therapeutic Medicine 17.5 (2019): 3989-3998.
Chicago
Du, M., Gu, J., Wang, J., Xue, Y., Ma, Y., Mo, X., Xue, S."Silk fibroin/poly(L‑lactic acid‑co‑ε‑caprolactone) electrospun nanofibrous scaffolds exert a protective effect following myocardial infarction". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3989-3998. https://doi.org/10.3892/etm.2019.7405
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team