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Bioinformatics analysis of microRNA expression between patients with and without latent tuberculosis infections

  • Authors:
    • Yang Lu
    • Xinmin Wang
    • Hongchang Dong
    • Xiaofang Wang
    • Pu Yang
    • Ling Han
    • Yingzi Wang
    • Zhihong Zheng
    • Wanjiang Zhang
    • Le Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, The Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, Xinjiang 832000, P.R. China, Department of Urinary Surgery, The First Affiliated Hospital, Medical College of Shihezi University, Shihezi, Xinjiang 832000, P.R. China, Department of Biochemistry, The Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, Xinjiang 832000, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3977-3988
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    Published online on: March 20, 2019
       https://doi.org/10.3892/etm.2019.7424
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Abstract

Tuberculosis (TB) is a globally prevalent infectious disease. The mechanisms of latent TB infection (LTBI) remain to be fully elucidated and may provide novel approaches for diagnosis. As therapeutic targets and molecular diagnostic markers, microRNAs (miRs) have been studied and utilized in various diseases. In the present study, the differentially expressed miRs (DEMs) in LTBI were screened and analyzed to determine the underlying mechanisms and identify potential biomarkers, thereby contributing to the diagnosis of LTBI. The GSE25435 and GSE29190 datasets from Gene Expression Omnibus were selected for analysis. The 2 datasets were analyzed individually using the Bioconductor package to screen the DEMs with specific cut‑off criteria [P<0.01 and |log (fold change)|≥1]. Target gene prediction and interaction network construction were performed using Targetscan, the Search Tool for the Retrieval of Interacting Genes and Proteins and Cytoscape individually, and were merged using the latter tool. The hub genes were finally selected based on their degree of connectivity (DC). Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using the KEGG and GENCLIP. A total of 144 DEMs were identified from the 2 datasets. By exploring the overlapping miRs in the two datasets, Homo sapiens (hsa)‑miR‑29a and hsa‑miR‑15b were identified to be decreased, while hsa‑miR‑576‑5p, hsa‑miR‑500 and hsa‑miR‑155 were identified to be upregulated. hsa‑miR‑500a‑3p and hsa‑miR‑29a‑3p, as well as 4 genes, namely cell division cycle (CDC)42, actin α1, skeletal muscle (ACTA1), phosphatase and tensin homolog (PTEN) and fos proto‑oncogene (FOS), were selected as the key factors in this regulatory network. A total of 9 signaling pathways, including phosphoinositide‑3 kinase (PI3K)/AKT and 11 biological processes, were identified to be associated with LTBI. In conclusion, the present analysis identified hsa‑miR‑500a‑3p and hsa‑miR‑29a‑3p, as well as CDC42, ACTA1, PTEN and FOS, as the most promising biomarkers and therapeutic candidates for LTBI. The PI3K/AKT signaling pathway is the key signaling pathway implicated in LTBI, and an in‑depth investigation of the efficiency of PI3K/AKT signaling inhibitors may be used to prevent a chronic state of infection in LTBI.
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View References

1 

WHO: Global tuberculosis report 2017. http://wwwwhoint/tb/publications/global_report/en/2017

2 

WHO: Latent tuberculosis infection Updated and consolidated guidelines for programmatic management. http://appswhoint/iris/bitstream/10665/260233/1/9789241550239-engpdf?ua=12018

3 

Palomino JC, Martin A, Von Groll A and Portaels F: Rapid culture-based methods for drug-resistance detection in Mycobacterium tuberculosis. J Microbiol Methods. 75:161–166. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Tang P and Johnston J: Treatment of latent tuberculosis infection. Curr Treat Options Infect Dis. 9:371–379. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Alvarez-León EE, Espinosa-Vega E, Santana-Rodriguez E, Molina-Cabrillana JM, Pérez-Arellano JL, Caminero JA and Serrano-Aguilar P: Screening for tuberculosis infection in spanish healthcare workers: Comparison of the QuantiFERON-TB gold in-tube test with the tuberculin skin test. Infect Control Hosp Epidemiol. 30:876–883. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Menzies D, Pai M and Comstock G: Meta-analysis: New tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research. Ann Intern Med. 146:340–354. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Jiang W, Shao L, Zhang Y, Zhang S, Meng C, Xu Y, Huang L, Wang Y, Wang Y, Weng X and Zhang W: High-sensitive and rapid detection of Mycobacterium tuberculosis infection by IFN-gamma release assay among HIV-infected individuals in BCG-vaccinated area. BMC Immunol. 10:312009. View Article : Google Scholar : PubMed/NCBI

8 

Matulis G, Juni P, Villiger PM and Gadola SD: Detection of latent tuberculosis in immunosuppressed patients with autoimmune diseases: Performance of a Mycobacterium tuberculosis antigen-specific interferon gamma assay. Ann Rheum Dis. 67:84–90. 2008. View Article : Google Scholar : PubMed/NCBI

9 

WHO: Guidelines on the management of latent tuberculosis infection. http://wwwwhoint/tb/publications/latent-tuberculosis-infection/en/2014.

10 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Lukiw WJ: Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. Neuroreport. 18:297–300. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Hayes J, Peruzzi PP and Lawler S: MicroRNAs in cancer: Biomarkers, functions and therapy. Trends Mol Med. 20:460–469. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Chen H, Lan HY, Roukos DH and Cho WC: Application of microRNAs in diabetes mellitus. J Endocrinol. 222:R1–R10. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Kumarswamy R and Thum T: Non-coding RNAs in cardiac remodeling and heart failure. Circ Res. 113:676–689. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Jin BX, Zhang YH, Jin WJ, Sun XY, Qiao GF, Wei YY, Sun LB, Zhang WH and Li N: MicroRNA panels as disease biomarkers distinguishing hepatitis B virus infection caused hepatitis and liver cirrhosis. Sci Rep. 5:150262015. View Article : Google Scholar : PubMed/NCBI

16 

Staedel C and Darfeuille F: MicroRNAs and bacterial infection. Cellular microbiology. 15:1496–1507. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Wu LS, Lee SW, Huang KY, Lee TY, Hsu PW and Weng JT: Systematic expression profiling analysis identifies specific microRNA-gene interactions that may differentiate between active and latent tuberculosis infection. Biomed Res Int. 2014:8951792014. View Article : Google Scholar : PubMed/NCBI

18 

Meng QL, Liu F, Yang XY, Liu XM, Zhang X, Zhang C1 and Zhang ZD: Identification of latent tuberculosis infection-related microRNAs in human U937 macrophages expressing Mycobacterium tuberculosis Hsp16.3. BMC Microbiol. 14:372014. View Article : Google Scholar : PubMed/NCBI

19 

Rai G, Rai R, Saeidian AH and Rai M: Microarray to deep sequencing: Transcriptome and miRNA profiling to elucidate molecular pathways in systemic lupus erythematosus. Immunol Res. 64:14–24. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Zheng Y, Qing T, Song Y, Zhu J, Yu Y, Shi W, Pusztai L and Shi L: Standardization efforts enabling next-generation sequencing and microarray based biomarkers for precision medicine. Biomark Med. 9:1265–1272. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Zheng L, Leung E, Lee N, Lui G, To KF, Chan RC and Ip M: Differential microRNA expression in human macrophages with Mycobacterium tuberculosis infection of Beijing/W and NON-Beijing/W strain types. PLoS One. 10:e01260182015. View Article : Google Scholar : PubMed/NCBI

22 

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, et al: Bioconductor: Open software development for computational biology and bioinformatics. Genome Biol. 5:R802004. View Article : Google Scholar : PubMed/NCBI

23 

Mizrachi E, Verbeke L, Christie N, Fierro AC, Mansfield SD, Davis MF, Gjersing E, Tuskan GA, Van Montagu M, Van de Peer Y, et al: Network-based integration of systems genetics data reveals pathways associated with lignocellulosic biomass accumulation and processing. Proc Natl Acad Sci USA. 114:1195–1200. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. Elife. 4:2015. View Article : Google Scholar

25 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43:(Database Issue). D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Muetze T, Goenawan IH, Wiencko HL, Bernal-Llinares M, Bryan K and Lynn DJ: contextual hub analysis tool (CHAT): A Cytoscape app for identifying contextually relevant hubs in biological networks. F1000 Res. 5:17452016. View Article : Google Scholar

27 

Su G, Morris JH, Demchak B and Bader GD: Biological network exploration with Cytoscape 3. Curr Protoc Bioinformatics. 47:8.13.1–24. 2014. View Article : Google Scholar

28 

Du J, Yuan Z, Ma Z, Song J, Xie X and Chen Y: KEGG-PATH: Kyoto encyclopedia of genes and genomes-based pathway analysis using a path analysis model. Mol Biosyst. 10:2441–2447. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Wang JH, Zhao LF, Lin P, Su XR, Chen SJ, Huang LQ, Wang HF, Zhang H, Hu ZF, Yao KT and Huang ZX: GenCLiP 2.0: A web server for functional clustering of genes and construction of molecular networks based on free terms. Bioinformatics. 30:2534–2536. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Xin H, Yang Y, Liu J, Li X, Li M, Feng B, Li Z, Zhang H, Li H, Shen F, et al: Association between tuberculosis and circulating microRNA hsa-let-7b and hsa-miR-30b: A pilot study in a Chinese population. Tuberculosis (Edinb). 99:63–69. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Fu Y, Yi Z, Li J and Li R: Deregulated microRNAs in CD4+ T cells from individuals with latent tuberculosis versus active tuberculosis. J Cell Mol Med. 18:503–513. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Wang C, Yang S, Sun G, Tang X, Lu S, Neyrolles O and Gao Q: Comparative miRNA expression profiles in individuals with latent and active tuberculosis. PLoS One. 6:e258322011. View Article : Google Scholar : PubMed/NCBI

33 

Ndzi EN, Nkenfou CN, Mekue LM, Zentilin L, Tamgue O, Pefura EWY, Kuiaté JR, Giacca M and Ndjolo A: MicroRNA hsa-miR-29a-3p is a plasma biomarker for the differential diagnosis and monitoring of tuberculosis. Tuberculosis (Edinb). 114:69–76. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Sabir N, Hussain T, Shah SZA, Peramo A, Zhao D and Zhou X: miRNAs in tuberculosis: new avenues for diagnosis and host-directed therapy. Front Microbiol. 9:6022018. View Article : Google Scholar : PubMed/NCBI

35 

Kleinsteuber K, Heesch K, Schattling S, Kohns M, Sander-Jülch C, Walzl G, Hesseling A, Mayatepek E, Fleischer B, Marx FM and Jacobsen M: Decreased expression of miR-21, miR-26a, miR-29a, and miR-142-3p in CD4+ T cells and peripheral blood from tuberculosis patients. PLoS One. 8:e616092013. View Article : Google Scholar : PubMed/NCBI

36 

Pan D, Pan M and Xu YM: Mir-29a expressions in peripheral blood mononuclear cell and cerebrospinal fluid: Diagnostic value in patients with pediatric tuberculous meningitis. Brain Res Bull. 130:231–235. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Zhao C, Wang G, Zhu Y, Li X, Yan F, Zhang C, Huang X and Zhang Y: Aberrant regulation of miR-15b in human malignant tumors and its effects on the hallmarks of cancer. Tumour Biol. 37:177–183. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Guerrieri F, Belloni L, D'Andrea D, Pediconi N, Le Pera L, Testoni B, Scisciani C, Floriot O, Zoulim F, Tramontano A and Levrero M: Genome-wide identification of direct HBx genomic targets. BMC Genomics. 18:1842017. View Article : Google Scholar : PubMed/NCBI

39 

Valencia-Quintana R, Sánchez-Alarcón J, Tenorio-Arvide MG, Deng Y, Montiel-González JM, Gómez-Arroyo S, Villalobos-Pietrini R, Cortés-Eslava J, Flores-Márquez AR and Arenas-Huertero F: The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: A review. Front Microbiol. 5:1022014. View Article : Google Scholar : PubMed/NCBI

40 

Aguilar BJ, Zhou H and Lu Q: Cdc42 signaling pathway inhibition as a therapeutic target in ras- related cancers. Curr Med Chem. 24:3485–3507. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Chang H, Sung JH, Moon SU, Kim HS, Kim JW and Lee JS: EGF Induced RET inhibitor resistance in CCDC6-RET lung cancer cells. Yonsei Med J. 58:9–18. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Kato F, Fiorentino FP, Alibés A, Perucho M, Sánchez-Céspedes M, Kohno T and Yokota J: MYCL is a target of a BET bromodomain inhibitor, JQ1, on growth suppression efficacy in small cell lung cancer cells. Oncotarget. 7:77378–77388. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Cui M, Augert A, Rongione M, Conkrite K, Parazzoli S, Nikitin AY, Ingolia N and MacPherson D: PTEN is a potent suppressor of small cell lung cancer. Mol Cancer Res. 12:654–659. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Nicoletti F, Fagone P, Meroni P, McCubrey J and Bendtzen K: mTOR as a multifunctional therapeutic target in HIV infection. Drug Discov Today. 16:715–721. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Nicoletti F, Lapenta C, Donati S, Spada M, Ranazzi A, Cacopardo B, Mangano K, Belardelli F, Perno C and Aquaro S: Inhibition of human immunodeficiency virus (HIV-1) infection in human peripheral blood leucocytes-SCID reconstituted mice by rapamycin. Clin Exp Immunol. 155:28–34. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Donia M, McCubrey JA, Bendtzen K and Nicoletti F: Potential use of rapamycin in HIV infection. Br J Clin Pharmacol. 70:784–793. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Nitulescu GM, Van De Venter M, Nitulescu G, Ungurianu A, Juzenas P, Peng Q, Olaru OT, Grădinaru D, Tsatsakis A, Tsoukalas D, et al: The Akt pathway in oncology therapy and beyond (Review). Int J Oncol. 53:2319–2331. 2018.PubMed/NCBI

48 

Chen D, Mao C, Zhou Y, Su Y, Liu S and Qi WQ: PF-04691502, a dual PI3K/mTOR inhibitor has potent pre-clinical activity by inducing apoptosis and G1 cell cycle arrest in aggressive B-cell non-Hodgkin lymphomas. Int J Oncol. 48:253–260. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Moon du G, Lee SE, Oh MM, Lee SC, Jeong SJ, Hong SK, Yoon CY, Byun SS, Park HS and Cheon J: NVP-BEZ235, a dual PI3K/mTOR inhibitor synergistically potentiates the antitumor effects of cisplatin in bladder cancer cells. Int J Oncol. 45:1027–1035. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Maksimovic-Ivanic D, Fagone P, McCubrey J, Bendtzen K, Mijatovic S and Nicoletti F: HIV-protease inhibitors for the treatment of cancer: Repositioning HIV protease inhibitors while developing more potent NO-hybridized derivatives? Int J Cancer. 140:1713–1726. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Mammana S, Bramanti P, Mazzon E, Cavalli E, Basile MS, Fagone P, Petralia MC, McCubrey JA, Nicoletti F and Mangano K: Preclinical evaluation of the PI3K/Akt/mTOR pathway in animal models of multiple sclerosis. Oncotarget. 9:8263–8277. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Fagone P, Mangano K, Pesce A, Portale TR, Puleo S and Nicoletti F: Emerging therapeutic targets for the treatment of hepatic fibrosis. Drug Discov Today. 21:369–375. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Wang FY, Wang XM, Wang C, Wang XF, Zhang YQ, Wu JD, Wu F, Zhang WJ and Zhang L: Suppression of Mcl-1 induces apoptosis in mouse peritoneal macrophages infected with Mycobacterium tuberculosis. Microbiol Immunol. 60:215–227. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Kim KH, Yang CS, Shin AR, Jeon SR, Park JK, Kim HJ and Jo EK: Mycobacterial heparin-binding hemagglutinin antigen activates inflammatory responses through PI3-K/Akt, NF-κB, and MAPK pathways. Immune Netw. 11:123–133. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lu Y, Wang X, Dong H, Wang X, Yang P, Han L, Wang Y, Zheng Z, Zhang W, Zhang L, Zhang L, et al: Bioinformatics analysis of microRNA expression between patients with and without latent tuberculosis infections. Exp Ther Med 17: 3977-3988, 2019.
APA
Lu, Y., Wang, X., Dong, H., Wang, X., Yang, P., Han, L. ... Zhang, L. (2019). Bioinformatics analysis of microRNA expression between patients with and without latent tuberculosis infections. Experimental and Therapeutic Medicine, 17, 3977-3988. https://doi.org/10.3892/etm.2019.7424
MLA
Lu, Y., Wang, X., Dong, H., Wang, X., Yang, P., Han, L., Wang, Y., Zheng, Z., Zhang, W., Zhang, L."Bioinformatics analysis of microRNA expression between patients with and without latent tuberculosis infections". Experimental and Therapeutic Medicine 17.5 (2019): 3977-3988.
Chicago
Lu, Y., Wang, X., Dong, H., Wang, X., Yang, P., Han, L., Wang, Y., Zheng, Z., Zhang, W., Zhang, L."Bioinformatics analysis of microRNA expression between patients with and without latent tuberculosis infections". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3977-3988. https://doi.org/10.3892/etm.2019.7424
Copy and paste a formatted citation
x
Spandidos Publications style
Lu Y, Wang X, Dong H, Wang X, Yang P, Han L, Wang Y, Zheng Z, Zhang W, Zhang L, Zhang L, et al: Bioinformatics analysis of microRNA expression between patients with and without latent tuberculosis infections. Exp Ther Med 17: 3977-3988, 2019.
APA
Lu, Y., Wang, X., Dong, H., Wang, X., Yang, P., Han, L. ... Zhang, L. (2019). Bioinformatics analysis of microRNA expression between patients with and without latent tuberculosis infections. Experimental and Therapeutic Medicine, 17, 3977-3988. https://doi.org/10.3892/etm.2019.7424
MLA
Lu, Y., Wang, X., Dong, H., Wang, X., Yang, P., Han, L., Wang, Y., Zheng, Z., Zhang, W., Zhang, L."Bioinformatics analysis of microRNA expression between patients with and without latent tuberculosis infections". Experimental and Therapeutic Medicine 17.5 (2019): 3977-3988.
Chicago
Lu, Y., Wang, X., Dong, H., Wang, X., Yang, P., Han, L., Wang, Y., Zheng, Z., Zhang, W., Zhang, L."Bioinformatics analysis of microRNA expression between patients with and without latent tuberculosis infections". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3977-3988. https://doi.org/10.3892/etm.2019.7424
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