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Analysis of therapeutic effect of intermittent and continuous phototherapy on neonatal hemolytic jaundice

  • Authors:
    • Shiying Zhou
    • Xiaoyan Wu
    • Aihua Ma
    • Min Zhang
    • Yanli Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Internal Medicine, Qilu Hospital of Shandong University (Qingdao), Qingdao, Shandong 266000, P.R. China, Department of Pediatrics, People's Hospital of Chiping, Liaocheng, Shandong 252000, P.R. China, PIVAS, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Stomatology, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4007-4012
    |
    Published online on: March 22, 2019
       https://doi.org/10.3892/etm.2019.7432
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Abstract

Clinical efficacy and adverse reaction rates of ABO hemolytic jaundice in patients with continuous and intermittent blue light irradiation were compared, to provide reference for clinical treatment of neonatal ABO hemolytic jaundice. A retrospective analysis of 307 patients with neonatal hemolytic jaundice admitted to Qilu Hospital of Shandong University (Qingdao) from January 2010 to December 2017 was undertaken. A total of 165 cases of children with continuous blue light irradiation and 142 cases of intermittent blue light irradiation were analyzed. Also the serum bilirubin levels, phototherapy time and frequency, treatment efficiency and adverse reaction rates were compared between the groups. The phototherapy time of children in the continuous phototherapy group was significantly higher from the intermittent phototherapy group, and the difference was statistically significant (t=26.800, P<0.001). Before treatment, there was no significant difference in serum bilirubin levels between continuous and intermittent phototherapy groups (P>0.050). Serum bilirubin levels of patients in continuous and intermittent phototherapy groups were lower than both previous and before treatment period, and differences were statistically significant (P<0.001). The overall effective rate of the continuous phototherapy group was higher than that of the intermittent phototherapy group (P>0.050). The adverse reaction rates after treatment in the continuous phototherapy group was significantly higher than the intermittent phototherapy group (P<0.050). After the symptomatic treatment in children, the adverse reactions ceased. The therapeutic effect of intermittent blue light irradiation on neonatal ABO hemolytic jaundice was consistent with the continuous blue light irradiation treatment, and the intermittent blue light irradiation treatment has a low adverse reaction rate, and is worth promotion in clinical practice.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou S, Wu X, Ma A, Zhang M and Liu Y: Analysis of therapeutic effect of intermittent and continuous phototherapy on neonatal hemolytic jaundice . Exp Ther Med 17: 4007-4012, 2019.
APA
Zhou, S., Wu, X., Ma, A., Zhang, M., & Liu, Y. (2019). Analysis of therapeutic effect of intermittent and continuous phototherapy on neonatal hemolytic jaundice . Experimental and Therapeutic Medicine, 17, 4007-4012. https://doi.org/10.3892/etm.2019.7432
MLA
Zhou, S., Wu, X., Ma, A., Zhang, M., Liu, Y."Analysis of therapeutic effect of intermittent and continuous phototherapy on neonatal hemolytic jaundice ". Experimental and Therapeutic Medicine 17.5 (2019): 4007-4012.
Chicago
Zhou, S., Wu, X., Ma, A., Zhang, M., Liu, Y."Analysis of therapeutic effect of intermittent and continuous phototherapy on neonatal hemolytic jaundice ". Experimental and Therapeutic Medicine 17, no. 5 (2019): 4007-4012. https://doi.org/10.3892/etm.2019.7432
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou S, Wu X, Ma A, Zhang M and Liu Y: Analysis of therapeutic effect of intermittent and continuous phototherapy on neonatal hemolytic jaundice . Exp Ther Med 17: 4007-4012, 2019.
APA
Zhou, S., Wu, X., Ma, A., Zhang, M., & Liu, Y. (2019). Analysis of therapeutic effect of intermittent and continuous phototherapy on neonatal hemolytic jaundice . Experimental and Therapeutic Medicine, 17, 4007-4012. https://doi.org/10.3892/etm.2019.7432
MLA
Zhou, S., Wu, X., Ma, A., Zhang, M., Liu, Y."Analysis of therapeutic effect of intermittent and continuous phototherapy on neonatal hemolytic jaundice ". Experimental and Therapeutic Medicine 17.5 (2019): 4007-4012.
Chicago
Zhou, S., Wu, X., Ma, A., Zhang, M., Liu, Y."Analysis of therapeutic effect of intermittent and continuous phototherapy on neonatal hemolytic jaundice ". Experimental and Therapeutic Medicine 17, no. 5 (2019): 4007-4012. https://doi.org/10.3892/etm.2019.7432
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