Impact of donor age on liver regeneration and function following adult living donor liver transplantation

Li,Mingyang; Chu,Zhiqiang; Tan,Zhijun; Jin,Yanyu; Xu,Min; Ji,Qian

doi:10.3892/etm.2019.7454

Impact of donor age on liver regeneration and function following adult living donor liver transplantation

Authors:
- Mingyang Li
- Zhiqiang Chu
- Zhijun Tan
- Yanyu Jin
- Min Xu
- Qian Ji
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Affiliations: First Central Clinical College of Tianjin Medical University, Tianjin 300192, P.R. China, Transplantation Center, Tianjin First Center Hospital, Tianjin 300192, P.R. China, Department of General Surgery, Tianjin First Center Hospital, Tianjin 300192, P.R. China, Department of Radiology, Tianjin First Center Hospital, Tianjin 300192, P.R. China
Published online on: March 29, 2019 https://doi.org/10.3892/etm.2019.7454
Pages: 3965-3970
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to evaluate the impact of donor age on liver function and regeneration following living donor liver transplantation. Donors were divided into an elderly donor group (age >50 years old; n=8) and a young donor group (age <30 years old; n=35). The recipients were also divided into an elderly group (age >50 years old; n=5) and a young group (age <30 years old; n=25). Alanine aminotransferase, aspartate aminotransferase, total bilirubin (TB) and prothrombin time were recorded 1‑5 days postoperatively. The liver regeneration ratio (LRR) was recorded 7 and 15 days postoperatively in donors and at 0.5, 1, 3 and 6 months postoperatively in recipients by contrast‑enhanced multi‑slice spiral computed tomography. Notably, the LRR in the young donor group was significantly increased compared with that in the elderly donor group at 7 days postoperatively (P<0.05). Among recipients, TB in the elderly group was significantly increased compared with that in the young group at 1‑5 days postoperatively (P<0.05). The residual liver regeneration rate was decreased and the time of jaundice was prolonged in recipients in the elderly group 7 days postoperatively, but donor age had little impact on the short‑term outcome of the residual liver and graft.

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