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let-7a suppresses liver fibrosis via TGFβ/SMAD signaling transduction pathway

  • Authors:
    • Yinghui Zhang
    • Jia Guo
    • Yongchao Li
    • Kai Jiao
    • Yingbo Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China, Laboratory Center, Medical Technology College of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China, Department of Thoracic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of General Surgery, The Second Affiliated Hospital of Qiqihar Medical University, P.R. China, Institute of Pathology, Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China
  • Pages: 3935-3942
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    Published online on: April 1, 2019
       https://doi.org/10.3892/etm.2019.7457
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Abstract

Liver fibrosis is the most common pathological outcome and the most severe complication of chronic liver diseases. Accumulating evidence suggests that miRNAs are involved in cell proliferation, differentiation, apoptosis, as well as the occurrence and development of various diseases. In this study, we found that the expression of let-7a was markedly decreased in the liver tissue samples and blood samples from patients with liver fibrosis compared with healthy volunteers. Furthermore, let-7a was downregulated in the liver tissues and blood samples in mouse models of liver fibrosis. Further analysis indicated that let-7a suppresses the activation level of hepatic stellate cells (HSCs). In addition, overexpression of let-7a reduced cell viability and promoted apoptosis of HSCs. Western blot analysis showed that let-7a might inhibit HSCs through TGFβ/SMAD signaling pathway. The present study provides a potential accurate target and vital evidence to better understand the underlying pathogenesis for early diagnosis and treatment of liver fibrosis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Guo J, Li Y, Jiao K and Zhang Y: let-7a suppresses liver fibrosis via TGFβ/SMAD signaling transduction pathway. Exp Ther Med 17: 3935-3942, 2019.
APA
Zhang, Y., Guo, J., Li, Y., Jiao, K., & Zhang, Y. (2019). let-7a suppresses liver fibrosis via TGFβ/SMAD signaling transduction pathway. Experimental and Therapeutic Medicine, 17, 3935-3942. https://doi.org/10.3892/etm.2019.7457
MLA
Zhang, Y., Guo, J., Li, Y., Jiao, K., Zhang, Y."let-7a suppresses liver fibrosis via TGFβ/SMAD signaling transduction pathway". Experimental and Therapeutic Medicine 17.5 (2019): 3935-3942.
Chicago
Zhang, Y., Guo, J., Li, Y., Jiao, K., Zhang, Y."let-7a suppresses liver fibrosis via TGFβ/SMAD signaling transduction pathway". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3935-3942. https://doi.org/10.3892/etm.2019.7457
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Guo J, Li Y, Jiao K and Zhang Y: let-7a suppresses liver fibrosis via TGFβ/SMAD signaling transduction pathway. Exp Ther Med 17: 3935-3942, 2019.
APA
Zhang, Y., Guo, J., Li, Y., Jiao, K., & Zhang, Y. (2019). let-7a suppresses liver fibrosis via TGFβ/SMAD signaling transduction pathway. Experimental and Therapeutic Medicine, 17, 3935-3942. https://doi.org/10.3892/etm.2019.7457
MLA
Zhang, Y., Guo, J., Li, Y., Jiao, K., Zhang, Y."let-7a suppresses liver fibrosis via TGFβ/SMAD signaling transduction pathway". Experimental and Therapeutic Medicine 17.5 (2019): 3935-3942.
Chicago
Zhang, Y., Guo, J., Li, Y., Jiao, K., Zhang, Y."let-7a suppresses liver fibrosis via TGFβ/SMAD signaling transduction pathway". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3935-3942. https://doi.org/10.3892/etm.2019.7457
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