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Review

Biosimilars in dermatology: The wind of change (Review)

  • Authors:
    • Maria Magdalena Constantin
    • Cristina Mihaela Cristea
    • Tatiana Taranu
    • Stefana Bucur
    • Traian Constantin
    • Alina Dinu
    • Mariana Jinga
    • Iuliana Elena Nita
  • View Affiliations / Copyright

    Affiliations: The Second Department of Dermatology, Colentina Clinical Hospital, 020125 Bucharest, Romania, Petroleum and Gas University of Ploiesti, Medical Office, 100680 Ploiesti, Romania, Department of Oral Dermatology, ‘Gr. T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania , Department of Urology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Gastroenterology, ‘Carol Davila’ Central Military Emergency University Hospital, 010825 Bucharest, Romania
  • Pages: 911-915
    |
    Published online on: April 18, 2019
       https://doi.org/10.3892/etm.2019.7505
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Abstract

Biosimilars are new drugs, highly similar copies of biological medicines, equally effective and safe but at lower prices. The aim of this brief review is to provide the current status of biosimilars approved in the European Union for dermatological use. We used PubMed for literature search up to June 2018. The keyword ‘biosimilars’ was searched and 1,691 items were found. From the 1,691 studies, we included 34 articles in our review. Biologics, biosimilars and generics are different types of drugs. Biosimilars are complex molecules produced by a difficult manufacturing process, and changes in product quality may affect its safety and efficacy. Now, there are 9 biosimilar medicines approved by European Medicines Agency (EMA) for plaque psoriasis and hidradenitis suppurativa: Amgevita, Solymbic, Cyltezo, Imraldi, Benepali, Erelzi, Flixabi, Inflectra and Remsima, and the number is increasing. In 2005, EMA issued the first guidelines for approval of biosimilars. Next‑generation biologics, called ‘biobetters’, have the same target or mechanism of action as previously approved biologics, but they have structural changes and an improved formulation. The debate over the future of biosimilars is far from being finished. The explosive development of biological therapy and the emergence of biosimilars represent a significant success in the effort to provide advanced healthcare to patients all over the world.
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Copy and paste a formatted citation
Spandidos Publications style
Constantin MM, Cristea CM, Taranu T, Bucur S, Constantin T, Dinu A, Jinga M and Nita IE: Biosimilars in dermatology: The wind of change (Review). Exp Ther Med 18: 911-915, 2019.
APA
Constantin, M.M., Cristea, C.M., Taranu, T., Bucur, S., Constantin, T., Dinu, A. ... Nita, I.E. (2019). Biosimilars in dermatology: The wind of change (Review). Experimental and Therapeutic Medicine, 18, 911-915. https://doi.org/10.3892/etm.2019.7505
MLA
Constantin, M. M., Cristea, C. M., Taranu, T., Bucur, S., Constantin, T., Dinu, A., Jinga, M., Nita, I. E."Biosimilars in dermatology: The wind of change (Review)". Experimental and Therapeutic Medicine 18.2 (2019): 911-915.
Chicago
Constantin, M. M., Cristea, C. M., Taranu, T., Bucur, S., Constantin, T., Dinu, A., Jinga, M., Nita, I. E."Biosimilars in dermatology: The wind of change (Review)". Experimental and Therapeutic Medicine 18, no. 2 (2019): 911-915. https://doi.org/10.3892/etm.2019.7505
Copy and paste a formatted citation
x
Spandidos Publications style
Constantin MM, Cristea CM, Taranu T, Bucur S, Constantin T, Dinu A, Jinga M and Nita IE: Biosimilars in dermatology: The wind of change (Review). Exp Ther Med 18: 911-915, 2019.
APA
Constantin, M.M., Cristea, C.M., Taranu, T., Bucur, S., Constantin, T., Dinu, A. ... Nita, I.E. (2019). Biosimilars in dermatology: The wind of change (Review). Experimental and Therapeutic Medicine, 18, 911-915. https://doi.org/10.3892/etm.2019.7505
MLA
Constantin, M. M., Cristea, C. M., Taranu, T., Bucur, S., Constantin, T., Dinu, A., Jinga, M., Nita, I. E."Biosimilars in dermatology: The wind of change (Review)". Experimental and Therapeutic Medicine 18.2 (2019): 911-915.
Chicago
Constantin, M. M., Cristea, C. M., Taranu, T., Bucur, S., Constantin, T., Dinu, A., Jinga, M., Nita, I. E."Biosimilars in dermatology: The wind of change (Review)". Experimental and Therapeutic Medicine 18, no. 2 (2019): 911-915. https://doi.org/10.3892/etm.2019.7505
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