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Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions (Review)

  • Authors:
    • Mihaela Adriana Ilie
    • Constantin Caruntu
    • Mircea Tampa
    • Simona-Roxana Georgescu
    • Clara Matei
    • Carolina Negrei
    • Rodica-Mariana Ion
    • Carolina Constantin
    • Monica Neagu
    • Daniel Boda
  • View Affiliations / Copyright

    Affiliations: Dermatology Research Laboratory, ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest 020021, Romania, Department of Physiology, ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest 020021, Romania, Department of Dermatology, ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest 020021, Romania, Department of Toxicology, Faculty of Pharmacy, ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest 020956, Romania, The National Institute for Research and Development in Chemistry and Petrochemistry - ICECHIM, Bucharest 060021, Romania, Department of Immunology, ‘Victor Babes’ National Institute of Pathology, Bucharest 050096, Romania
    Copyright: © Ilie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 916-925
    |
    Published online on: April 19, 2019
       https://doi.org/10.3892/etm.2019.7513
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Abstract

Capsaicin is a natural protoalkaloid recognized as the main pungent component in hot peppers (Capsicum annuum L.). The capsaicin receptor is highly expressed in the unmyelinated type C nerve fibers originating from small diameter sensory neurons in dorsal root ganglia and cranial nerve ganglia correspondents. Capsaicin and related vanilloids have a variety of effects on primary sensory neurons function, from sensory neuron excitation characterized by local burning sensation and neurogenic inflammation, followed by conduction blockage accompanied by reversible ultrastructural changes of peripheral nociceptive endings (desensitization), going as far as irreversible degenerative changes (neurotoxicity). The main role in capsaicin-induced neurogenic inflammation relies on the capsaicin sensitive, small diameter primary sensory neurons, therefore its evaluation could be used as a diagnostic instrument in functional alterations of cutaneous sensory nerve fibers. Moreover, capsaicin-induced desensitization and neurotoxicity explain the analgesic/anti-nociceptive and anti‑inflammatory effects of topical capsaicin and its potential use in the management of painful and inflammatory conditions. In this study, we describe the effects of capsaicin on neurogenic inflammation and nociception, as well as its potential diagnostic value and therapeutic impact in various conditions involving impairment of sensory nerve fibers.
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Copy and paste a formatted citation
Spandidos Publications style
Ilie MA, Caruntu C, Tampa M, Georgescu S, Matei C, Negrei C, Ion R, Constantin C, Neagu M, Boda D, Boda D, et al: Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions (Review). Exp Ther Med 18: 916-925, 2019.
APA
Ilie, M.A., Caruntu, C., Tampa, M., Georgescu, S., Matei, C., Negrei, C. ... Boda, D. (2019). Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions (Review). Experimental and Therapeutic Medicine, 18, 916-925. https://doi.org/10.3892/etm.2019.7513
MLA
Ilie, M. A., Caruntu, C., Tampa, M., Georgescu, S., Matei, C., Negrei, C., Ion, R., Constantin, C., Neagu, M., Boda, D."Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions (Review)". Experimental and Therapeutic Medicine 18.2 (2019): 916-925.
Chicago
Ilie, M. A., Caruntu, C., Tampa, M., Georgescu, S., Matei, C., Negrei, C., Ion, R., Constantin, C., Neagu, M., Boda, D."Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions (Review)". Experimental and Therapeutic Medicine 18, no. 2 (2019): 916-925. https://doi.org/10.3892/etm.2019.7513
Copy and paste a formatted citation
x
Spandidos Publications style
Ilie MA, Caruntu C, Tampa M, Georgescu S, Matei C, Negrei C, Ion R, Constantin C, Neagu M, Boda D, Boda D, et al: Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions (Review). Exp Ther Med 18: 916-925, 2019.
APA
Ilie, M.A., Caruntu, C., Tampa, M., Georgescu, S., Matei, C., Negrei, C. ... Boda, D. (2019). Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions (Review). Experimental and Therapeutic Medicine, 18, 916-925. https://doi.org/10.3892/etm.2019.7513
MLA
Ilie, M. A., Caruntu, C., Tampa, M., Georgescu, S., Matei, C., Negrei, C., Ion, R., Constantin, C., Neagu, M., Boda, D."Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions (Review)". Experimental and Therapeutic Medicine 18.2 (2019): 916-925.
Chicago
Ilie, M. A., Caruntu, C., Tampa, M., Georgescu, S., Matei, C., Negrei, C., Ion, R., Constantin, C., Neagu, M., Boda, D."Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions (Review)". Experimental and Therapeutic Medicine 18, no. 2 (2019): 916-925. https://doi.org/10.3892/etm.2019.7513
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