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Article

Effect of white mange mixture in a murine model of psoriasis

  • Authors:
    • Jiangtao Guo
    • Jie Liu
  • View Affiliations / Copyright

    Affiliations: Pharmaceutical College, Guiyang University of Chinese Medicine, Guiyang, Guizhou 550025, P.R. China
  • Pages: 881-887
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    Published online on: June 4, 2019
       https://doi.org/10.3892/etm.2019.7641
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Abstract

Psoriasis is an autoimmune disease with periods of remission or aggravation. Until now, no effective treatment has been developed. The aim of this study was to assess the effect of the traditional Chinese medicine white mange mixture in a murine model of vaginal psoriasis. Female mice (n=70) were randomly divided into seven groups as follows: negative control group, positive control group, acitretin group, Xiaoying granule group, high-dose white mange mixture group, medium-dose white mange mixture group, and low-dose white mange mixture group. After vaginal psoriasis mouse model design, the inhibition of keratinocyte (KC) cell proliferating cell nuclear antigen (PCNA) was achieved by SP immunohistochemical method, spleen T lymphocyte apoptosis detection was assessed by using electron microscopy and granulocyte colony stimulating factor (GM‑CSF) levels were detected by ELISA method. According to our results, T lymphocyte nucleus appearance in the negative control group was normal whereas in all the doses of white mange mixture the nucleus significantly showed apoptotic trend. Compared with the negative control group, the amount of GM‑CSF in the serum of the model was significantly increased (P<0.01) while administration of white mange mixture in different doses decreased the GM‑CSF content significantly (P<0.01). White mange mixture can significantly inhibit vaginal psoriasis in a mouse model by decreasing the amount of epithelium KC cell PCNA and production of the inflammatory cytokines GM‑CSF in serum.
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Copy and paste a formatted citation
Spandidos Publications style
Guo J and Liu J: Effect of white mange mixture in a murine model of psoriasis. Exp Ther Med 18: 881-887, 2019.
APA
Guo, J., & Liu, J. (2019). Effect of white mange mixture in a murine model of psoriasis. Experimental and Therapeutic Medicine, 18, 881-887. https://doi.org/10.3892/etm.2019.7641
MLA
Guo, J., Liu, J."Effect of white mange mixture in a murine model of psoriasis". Experimental and Therapeutic Medicine 18.2 (2019): 881-887.
Chicago
Guo, J., Liu, J."Effect of white mange mixture in a murine model of psoriasis". Experimental and Therapeutic Medicine 18, no. 2 (2019): 881-887. https://doi.org/10.3892/etm.2019.7641
Copy and paste a formatted citation
x
Spandidos Publications style
Guo J and Liu J: Effect of white mange mixture in a murine model of psoriasis. Exp Ther Med 18: 881-887, 2019.
APA
Guo, J., & Liu, J. (2019). Effect of white mange mixture in a murine model of psoriasis. Experimental and Therapeutic Medicine, 18, 881-887. https://doi.org/10.3892/etm.2019.7641
MLA
Guo, J., Liu, J."Effect of white mange mixture in a murine model of psoriasis". Experimental and Therapeutic Medicine 18.2 (2019): 881-887.
Chicago
Guo, J., Liu, J."Effect of white mange mixture in a murine model of psoriasis". Experimental and Therapeutic Medicine 18, no. 2 (2019): 881-887. https://doi.org/10.3892/etm.2019.7641
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