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Ellagic acid, a plant phenolic compound, activates cyclooxygenase‑mediated prostaglandin production

  • Authors:
    • Hui Rong Wang
    • Hao Chen Sui
    • Bao Ting Zhu
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    Affiliations: Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P.R. China, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 987-996
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    Published online on: June 13, 2019
       https://doi.org/10.3892/etm.2019.7667
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Abstract

In recent years, ellagic acid (EA), a naturally‑occurring phenolic compound richly contained in some of the human food sources such as Longan and Litchi, was reported to have a number of biological effects. Based on our earlier 3D‑QSAR/CoMFA models for cyclooxygenase (COX) I and II, we hypothesize that EA may have the potential to modulate the catalytic activity of COX enzymes, and this hypothesis is examined in the present study. The results from both in vitro and in vivo experiments show that EA is an activator of COX enzyme‑catalyzed production of prostaglandin E2, a representative prostaglandin tested. Mechanistically, EA can activate the peroxidase active site of COX enzymes by serving as a co‑substrate, presumably for the reduction of protoporphorin IX with FeIV inside. The effect of EA is abrogated by the co‑presence of galangin, which is known to bind to COX's peroxidase active site and thereby blocks the effect of the reducing co‑substrates. In view of the known physiological functions of COX enzymes in the body, it is suggested that some of the pharmacological and/or toxicological effects of EA may result from an increased production of certain prostaglandins and their related derivatives in the body.
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1 

Mämmelä P, Savolainen H, Lindroos L, Kangas J and Vartiainen T: Analysis of oak tannins by liquid chromatography-electrospray ionisation mass spectrometry. J Chromatogr A. 891:75–83. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Nierenstein M: The formation of ellagic acid from galloyl-glycine by penicillium. Biochem J. 9:240–244. 1915. View Article : Google Scholar : PubMed/NCBI

3 

Nakai S: Myriophyllum spicatum-released allelopathic polyphenols inhibiting growth of blue-green algae Microcystis aeruginosa. Water Res. 34:3026–3032. 2000. View Article : Google Scholar

4 

Prasad KN, Yang B, Yang S, Chen Y, Zhao M, Ashraf M and Jiang Y: Identification of phenolic compounds and appraisal of antioxidant and antityrosinase activities from litchi (Litchi sinensis Sonn.) seeds. Food Chem. 116:1–7. 2009. View Article : Google Scholar

5 

Estela de Rezende Q, Patto de Abreu CM, Kelly da Silva O, Vinicius de Oliveira R and Fráguas RM: Bioactive phytochemicals and antioxidant activity in fresh and dried lychee fractions. Rev Ciênc Agron. 46:163–169. 2015. View Article : Google Scholar

6 

Soong YY and Barlow PJ: Isolation and structure elucidation of phenolic compounds from longan (Dimocarpus longan Lour.) seed by high-performance liquid chromatography-electrospray ionization mass spectrometry. J Chromatogr A. 1085:270–277. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Zheng G, Xu L, Wu P, Xie H, Jiang Y, Chen F and Wei X: Polyphenols from longan seeds and their radical-scavenging activity. Food Chem. 116:433–436. 2009. View Article : Google Scholar

8 

Rangkadilok N, Sitthimonchai S, Worasuttayangkurn L, Mahidol C, Ruchirawat M and Satayavivad J: Evaluation of free radical scavenging and antityrosinase activities of standardized longan fruit extract. Food Chem Toxicol. 45:328–336. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Tseng HC, Wu WT, Huang HS and Wu MC: Antimicrobial activities of various fractions of longan (Dimocarpus longan Lour. Fen Ke) seed extract. Int J Food Sci Nutr. 65:589–593. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Vattem DA and Shetty K: Biological function of ellagic acid: A review. J Food Biochem. 29:234–266. 2005. View Article : Google Scholar

11 

Usta C, Ozdemir S, Schiariti M and Puddu PE: The pharmacological use of ellagic acid-rich pomegranate fruit. Int J Food Sci Nutr. 64:907–913. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Infante R, Contador L, Rubio P, Aros D and Peña-Neira Á: Postharvest sensory and phenolic characterization of ‘Elegant Lady’ and ‘Carson’ peaches. Chil J Agric Res. 71:445–451. 2011. View Article : Google Scholar

13 

Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG and Heber D: In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem. 16:360–367. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Vattem DA and Shetty K: Biological function of ellagic acid: A Review. J Food Biochem. 29:234–266. 2005. View Article : Google Scholar

15 

Emanuele S, Lauricella M, Calvaruso G, D'Anneo A and Giuliano M: Litchi chinensis as a functional food and a source of antitumor compounds: An overview and a description of biochemical pathways. Nutrients. 9:E9922017. View Article : Google Scholar : PubMed/NCBI

16 

Narayanan BA, Geoffroy O, Willingham MC, Re GG and Nixon DW: p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett. 136:215–221. 1999. View Article : Google Scholar : PubMed/NCBI

17 

Mandal S, Shivapurkar NM, Galati AJ and Stoner GD: Inhibition of N-nitrosobenzylmethylamine metabolism and DNA binding in cultured rat esophagus by ellagic acid. Carcinogenesis. 9:1313–1316. 1988. View Article : Google Scholar : PubMed/NCBI

18 

Mandal S and Stoner GD: Inhibition of N-nitrosobenzylmethylamine-induced esophageal tumorigenesis in rats by ellagic acid. Carcinogenesis. 11:55–61. 1990. View Article : Google Scholar : PubMed/NCBI

19 

Teel RW, Babcock MS, Dixit R and Stoner GD: Ellagic acid toxicity and interaction with benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol in human bronchial epithelial cells. Cell Biol Toxicol. 2:53–62. 1986. View Article : Google Scholar : PubMed/NCBI

20 

Casewatch, . https://www.casewatch.net/fdawarning/prod/2008/best_on_earth.shtmlDecember 2–2018

21 

Marnett LJ: Cyclooxygenase mechanisms. Curr Opin Chem Biol. 4:545–552. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Williams CS, Mann M and DuBois RN: The role of cyclooxygenases in inflammation, cancer, and development. Oncogene. 18:7908–7916. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Fitzpatrick FA: Cyclooxygenase enzymes: Regulation and function. Curr Pharm Des. 10:577–588. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Mitchell JA and Kirkby NS: Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system. Br J Pharmacol. Feb 21–2018.(Epub ahead of print).

25 

Duggan KC, Walters MJ, Musee J, Harp JM, Kiefer JR, Oates JA and Marnett LJ: Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. J Biol Chem. 285:34950–34959. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Blobaum AL and Marnett LJ: Structural and functional basis of cyclooxygenase inhibition. J Med Chem. 50:1425–1441. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Marnett LJ, Rowlinson SW, Goodwin DC, Kalgutkar AS and Lanzo CA: Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition. J Biol Chem. 274:22903–22906. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Kurumbail RG, Kiefer JR and Marnett LJ: Cyclooxygenase enzymes: Catalysis and inhibition. Curr Opin Struct Biol. 11:752–760. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Bai HW and Zhu BT: Strong activation of cyclooxygenase I and II catalytic activity by dietary bioflavonoids. J Lipid Res. 49:2557–2570. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Bai HW and Zhu BT: Myricetin and quercetin are naturally occurring co-substrates of cyclooxygenases in vivo. Prostaglandins Leukot Essent Fatty Acids. 82:45–50. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Wang P, Bai HW and Zhu BT: Structural basis for certain naturally occurring bioflavonoids to function as reducing co-substrates of cyclooxygenase I and II. PloS One 2010,. 5:e123162010. View Article : Google Scholar

32 

Gupta K, Selinsky BS, Kaub CJ, Katz AK and Loll PJ: The 2.0 Å resolution crystal structure of prostaglandin H2 synthase-1: Structural insights into an unusual peroxidase. J Mol Biol. 335:503–518. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Duggan KC, Walters MJ, Musee J, Harp JM, Kiefer JR, Oates JA and Marnett LM: Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. J Biol Chem. 285:34950–34959. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Im W, Lee MS and Brooks CL III: Generalized born model with a simple smoothing function. J Comput Chem. 24:1691–1702. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Uciechowska U, Schemies J, Scharfe M, Lawson M, Wichapong K, Jung M and Sippl W: Binding free energy calculations and biological testing of novel thiobarbiturates as inhibitors of the human NAD+ dependent histone deacetylase Sirt2. Med Chem Comm. 3:167–173. 2012. View Article : Google Scholar

36 

Pouplana R, Lozano JJ and Ruiz J: Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2). J Mol Graph Model. 20:329–343. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Zhu BT, Bai HW, Rao S and Sui HC: Galangin inhibits cyclooxygenase by blocking the function of the reducing cosubstrate at the peroxidase site. FASEB J. submitted. 2018.

38 

Sui HC and Zhu BT: Catalytic mechanism of the peroxidase activity of human cyclooxygenase and the role of phenol as a reducing co-substrate. Sci Rep. submitted. 2018.

39 

Anslyn EV and Dougherty DA: Modern Physical Organic Chemistry. University Science; Sausalito, CA: 2004

40 

Chen H: The production and uses of litchis in China. http://ir4.rutgers.edu/GMUS/presentation%20pdf/day1Chen.pdfApril. 2018

41 

Menzel CM and Waite GK: Litchi and Longan. Botany, Production and Uses. CABI Publishing; Wallingford, UK: 2005

42 

Spencer PS and Palmer VS: The enigma of litchi toxicity: An emerging health concern in southern Asia. Lancet Glob Health. 5:e383–e384. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Paireau J, Tuan NH, Lefrançois R, Buckwalter MR, Nghia ND, Hien NT, Lortholary O, Poirée S, Manuguerra JC, Gessain A, et al: Litchi-associated acute encephalitis in children, Northern Vietnam, 2004–2009. Emerg Infect Dis. 18:1817–1824. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Shrivastava A, Kumar A, Thomas JD, Laserson KF, Bhushan G, Carter MD, Chhabra M, Mittal V, Khare S, Sejvar JJ, et al: Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: A case-control study. Lancet Glob Health. 5:e458–e466. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Islam MS, Sharif AR, Sazzad HMS, Khan AKMD, Hasan M, Akter S, Rahman M, Luby SP, Heffelfinger JD and Gurley ES: Outbreak of sudden death with acute encephalitis syndrome among children associated with exposure to lychee orchards in Northern Bangladesh, 2012. Am J Trop Med Hyg. 97:949–957. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Krumholz HM, Ross JS, Presler AH and Egilman DS: What have we learnt from Vioxx? BMJ. 334:120–123. 2007. View Article : Google Scholar : PubMed/NCBI

47 

McGettigan P and Henry D: Cardiovascular risk and inhibition of cyclooxygenase: A systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2. JAMA. 296:1633–1644. 2006. View Article : Google Scholar : PubMed/NCBI

48 

White WB: Cardiovascular risk, hypertension, and NSAIDs. Curr Rheumatol Rep. 9:36–43. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang HR, Sui HC and Zhu BT: Ellagic acid, a plant phenolic compound, activates cyclooxygenase‑mediated prostaglandin production. Exp Ther Med 18: 987-996, 2019.
APA
Wang, H.R., Sui, H.C., & Zhu, B.T. (2019). Ellagic acid, a plant phenolic compound, activates cyclooxygenase‑mediated prostaglandin production. Experimental and Therapeutic Medicine, 18, 987-996. https://doi.org/10.3892/etm.2019.7667
MLA
Wang, H. R., Sui, H. C., Zhu, B. T."Ellagic acid, a plant phenolic compound, activates cyclooxygenase‑mediated prostaglandin production". Experimental and Therapeutic Medicine 18.2 (2019): 987-996.
Chicago
Wang, H. R., Sui, H. C., Zhu, B. T."Ellagic acid, a plant phenolic compound, activates cyclooxygenase‑mediated prostaglandin production". Experimental and Therapeutic Medicine 18, no. 2 (2019): 987-996. https://doi.org/10.3892/etm.2019.7667
Copy and paste a formatted citation
x
Spandidos Publications style
Wang HR, Sui HC and Zhu BT: Ellagic acid, a plant phenolic compound, activates cyclooxygenase‑mediated prostaglandin production. Exp Ther Med 18: 987-996, 2019.
APA
Wang, H.R., Sui, H.C., & Zhu, B.T. (2019). Ellagic acid, a plant phenolic compound, activates cyclooxygenase‑mediated prostaglandin production. Experimental and Therapeutic Medicine, 18, 987-996. https://doi.org/10.3892/etm.2019.7667
MLA
Wang, H. R., Sui, H. C., Zhu, B. T."Ellagic acid, a plant phenolic compound, activates cyclooxygenase‑mediated prostaglandin production". Experimental and Therapeutic Medicine 18.2 (2019): 987-996.
Chicago
Wang, H. R., Sui, H. C., Zhu, B. T."Ellagic acid, a plant phenolic compound, activates cyclooxygenase‑mediated prostaglandin production". Experimental and Therapeutic Medicine 18, no. 2 (2019): 987-996. https://doi.org/10.3892/etm.2019.7667
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