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Article

Chronic restraint stress induces esophageal fibrosis with enhanced oxidative stress in a murine model

  • Authors:
    • Maimaiti Yisireyili
    • Wubulikasimu Wulamu
    • Aikebaier Aili
    • Yiliang Li
    • Aziguli Alimujiang
    • Aliyeguli Aipire
    • Maimaitiaili Aizezi
    • Weimin Zhang
    • Zhengyi Cao
    • Abulajiang Mijiti
    • Kelimu Abudureyimu
  • View Affiliations / Copyright

    Affiliations: Research Institute of General and Minimally Invasive Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang 830001, P.R. China, Department of Minimally Invasive Surgery, Hernia and Abdominal Wall Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang 830001, P.R. China, Department of Obstetrics and Gynecology Clinic, Hernia and Abdominal Wall Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang 830001, P.R. China, Department of Cardiac Surgery, Hernia and Abdominal Wall Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang 830001, P.R. China
  • Pages: 1375-1383
    |
    Published online on: June 13, 2019
       https://doi.org/10.3892/etm.2019.7669
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Abstract

Although the underlying mechanism of stress remains unknown, it has been associated with the pathophysiology of gastroesophageal reflux diseases, the development of which appear to be accelerated by oxidative stress and fibrosis. The aim of the current study was to investigate the effect of chronic restraint stress on esophageal oxidative stress and fibrosis, as well as the impact of oxidative stress in a murine model whereby 8‑week old C57BL/6J male mice were subjected to intermittent chronic restraint stress for a two‑week period. The current study demonstrated that chronic restraint stress significantly reduced the body weight of mice compared with the control group. Although chronic restraint stress did not significantly alter the levels of triglycerides or cholesterol, free fatty acid concentration was significantly increased compared with the control group. Furthermore, chronic restraint stress significantly upregulated the expression levels of several fibrotic biomarkers including collagen type I, transforming growth factor β‑1, α‑smooth muscle actin and SMAD‑3 compared with the control group. In addition, the expression levels of the reactive oxygen species (ROS) NADPH oxidase‑4 and malondialdehyde were significantly increased, while the expression levels of nuclear factor erythroid 2‑related factor 2 and heme oxygenase‑1 were significantly decreased in esophageal tissue from mice in the chronic restraint stress group compared with the control group. In conclusion, chronic restraint stress may induce esophageal fibrosis by accumulating ROS and increasing fibrotic gene expression in a murine model.
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Copy and paste a formatted citation
Spandidos Publications style
Yisireyili M, Wulamu W, Aili A, Li Y, Alimujiang A, Aipire A, Aizezi M, Zhang W, Cao Z, Mijiti A, Mijiti A, et al: Chronic restraint stress induces esophageal fibrosis with enhanced oxidative stress in a murine model. Exp Ther Med 18: 1375-1383, 2019.
APA
Yisireyili, M., Wulamu, W., Aili, A., Li, Y., Alimujiang, A., Aipire, A. ... Abudureyimu, K. (2019). Chronic restraint stress induces esophageal fibrosis with enhanced oxidative stress in a murine model. Experimental and Therapeutic Medicine, 18, 1375-1383. https://doi.org/10.3892/etm.2019.7669
MLA
Yisireyili, M., Wulamu, W., Aili, A., Li, Y., Alimujiang, A., Aipire, A., Aizezi, M., Zhang, W., Cao, Z., Mijiti, A., Abudureyimu, K."Chronic restraint stress induces esophageal fibrosis with enhanced oxidative stress in a murine model". Experimental and Therapeutic Medicine 18.2 (2019): 1375-1383.
Chicago
Yisireyili, M., Wulamu, W., Aili, A., Li, Y., Alimujiang, A., Aipire, A., Aizezi, M., Zhang, W., Cao, Z., Mijiti, A., Abudureyimu, K."Chronic restraint stress induces esophageal fibrosis with enhanced oxidative stress in a murine model". Experimental and Therapeutic Medicine 18, no. 2 (2019): 1375-1383. https://doi.org/10.3892/etm.2019.7669
Copy and paste a formatted citation
x
Spandidos Publications style
Yisireyili M, Wulamu W, Aili A, Li Y, Alimujiang A, Aipire A, Aizezi M, Zhang W, Cao Z, Mijiti A, Mijiti A, et al: Chronic restraint stress induces esophageal fibrosis with enhanced oxidative stress in a murine model. Exp Ther Med 18: 1375-1383, 2019.
APA
Yisireyili, M., Wulamu, W., Aili, A., Li, Y., Alimujiang, A., Aipire, A. ... Abudureyimu, K. (2019). Chronic restraint stress induces esophageal fibrosis with enhanced oxidative stress in a murine model. Experimental and Therapeutic Medicine, 18, 1375-1383. https://doi.org/10.3892/etm.2019.7669
MLA
Yisireyili, M., Wulamu, W., Aili, A., Li, Y., Alimujiang, A., Aipire, A., Aizezi, M., Zhang, W., Cao, Z., Mijiti, A., Abudureyimu, K."Chronic restraint stress induces esophageal fibrosis with enhanced oxidative stress in a murine model". Experimental and Therapeutic Medicine 18.2 (2019): 1375-1383.
Chicago
Yisireyili, M., Wulamu, W., Aili, A., Li, Y., Alimujiang, A., Aipire, A., Aizezi, M., Zhang, W., Cao, Z., Mijiti, A., Abudureyimu, K."Chronic restraint stress induces esophageal fibrosis with enhanced oxidative stress in a murine model". Experimental and Therapeutic Medicine 18, no. 2 (2019): 1375-1383. https://doi.org/10.3892/etm.2019.7669
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