Open Access

LncRNA NKILA was upregulated in diabetic cardiomyopathy with early prediction values

  • Authors:
    • Qingyong Li
    • Panrong Li
    • Jinling Su
    • Suping Liu
    • Xiaoman Yang
    • Yuejin Yang
    • Suocheng Niu
  • View Affiliations

  • Published online on: June 13, 2019     https://doi.org/10.3892/etm.2019.7671
  • Pages: 1221-1225
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Nuclear factor‑κB interacting long non‑coding RNA (LncRNA NKILA) is a well‑studied tumor suppressor lncRNA in several types of malignancies. The present study reports the involvement of this lncRNA in diabetic cardiomyopathy (DC). A 8‑year‑follow‑up study on 312 diabetic patients without exhibiting obvious complications demonstrated that plasma lncRNA NKILA levels were upregulated specifically in diabetic patients who developed DC but not in patients with other complications. Plasma levels of lncRNA NKILA at 6 months prior to diagnosis is sufficient to distinguish patients with DC from other diabetic patients without significant complications. Although in vitro experiments demonstrated that lncRNA NKILA expression in cardiomyocyte cells was not affected by high‑glucose treatment, ectopic lncRNA NKILA expression and lncRNA NKILA knockdown potentiated, and inhibited cardiomyocyte apoptosis, respectively. Therefore, the data from the present study suggests that overexpression of lncRNA NKILA is involved in DC, and overexpression of lncRNA NKILA may serve as a therapeutic target for treating DC.
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August-2019
Volume 18 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li Q, Li P, Su J, Liu S, Yang X, Yang Y and Niu S: LncRNA NKILA was upregulated in diabetic cardiomyopathy with early prediction values. Exp Ther Med 18: 1221-1225, 2019
APA
Li, Q., Li, P., Su, J., Liu, S., Yang, X., Yang, Y., & Niu, S. (2019). LncRNA NKILA was upregulated in diabetic cardiomyopathy with early prediction values. Experimental and Therapeutic Medicine, 18, 1221-1225. https://doi.org/10.3892/etm.2019.7671
MLA
Li, Q., Li, P., Su, J., Liu, S., Yang, X., Yang, Y., Niu, S."LncRNA NKILA was upregulated in diabetic cardiomyopathy with early prediction values". Experimental and Therapeutic Medicine 18.2 (2019): 1221-1225.
Chicago
Li, Q., Li, P., Su, J., Liu, S., Yang, X., Yang, Y., Niu, S."LncRNA NKILA was upregulated in diabetic cardiomyopathy with early prediction values". Experimental and Therapeutic Medicine 18, no. 2 (2019): 1221-1225. https://doi.org/10.3892/etm.2019.7671