LncRNA NKILA was upregulated in diabetic cardiomyopathy with early prediction values

Li,Qingyong; Li,Panrong; Su,Jinling; Liu,Suping; Yang,Xiaoman; Yang,Yuejin; Niu,Suocheng

doi:10.3892/etm.2019.7671

August-2019 Volume 18 Issue 2

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August-2019 Volume 18 Issue 2

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Article Open Access

LncRNA NKILA was upregulated in diabetic cardiomyopathy with early prediction values

Authors:
- Qingyong Li
- Panrong Li
- Jinling Su
- Suping Liu
- Xiaoman Yang
- Yuejin Yang
- Suocheng Niu
View Affiliations / Copyright

Affiliations: The Second Department of Cardiology, The People's Hospital of Puyang, Puyang, Henan 457000, P.R. China, Fuwai Cardiovascular Hospital, Chinese Academy of Medical Sciences, Beijing 100037, P.R. China

Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1221-1225
|
Published online on: June 13, 2019

https://doi.org/10.3892/etm.2019.7671
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Abstract

Nuclear factor‑κB interacting long non‑coding RNA (LncRNA NKILA) is a well‑studied tumor suppressor lncRNA in several types of malignancies. The present study reports the involvement of this lncRNA in diabetic cardiomyopathy (DC). A 8‑year‑follow‑up study on 312 diabetic patients without exhibiting obvious complications demonstrated that plasma lncRNA NKILA levels were upregulated specifically in diabetic patients who developed DC but not in patients with other complications. Plasma levels of lncRNA NKILA at 6 months prior to diagnosis is sufficient to distinguish patients with DC from other diabetic patients without significant complications. Although in vitro experiments demonstrated that lncRNA NKILA expression in cardiomyocyte cells was not affected by high‑glucose treatment, ectopic lncRNA NKILA expression and lncRNA NKILA knockdown potentiated, and inhibited cardiomyocyte apoptosis, respectively. Therefore, the data from the present study suggests that overexpression of lncRNA NKILA is involved in DC, and overexpression of lncRNA NKILA may serve as a therapeutic target for treating DC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

LncRNA NKILA was upregulated in diabetic cardiomyopathy with early prediction values

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