Prebiotics and probiotics in atopic dermatitis (Review)

Rusu,Emilia; Enache,Georgiana; Cursaru,Raluca; Alexescu,Alexandra; Radu,Raluca; Onila,Oana; Cavallioti,Teodora; Rusu,Florin; Posea,Mihaela; Jinga,Mariana; Radulian,Gabriela

doi:10.3892/etm.2019.7678

Prebiotics and probiotics in atopic dermatitis (Review)

Authors:
- Emilia Rusu
- Georgiana Enache
- Raluca Cursaru
- Alexandra Alexescu
- Raluca Radu
- Oana Onila
- Teodora Cavallioti
- Florin Rusu
- Mihaela Posea
- Mariana Jinga
- Gabriela Radulian
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Affiliations: Department 2 Infectious Diseases, Epidemiology, Microbiology, Parasitology, Virology, Diabetes, Endocrinology, ‘Carol Davila’ University of Medicine and Farmacy, 010458 Bucharest, Romania, Department of Urology, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 010825 Bucharest, Romania, Department of Diabetes, Nutrition and Metabolic Diseases, Smart Nutrition Clinic, 051075 Bucharest, Romania, Department of Gastroenterology, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 051075 Bucharest, Romania
Published online on: June 14, 2019 https://doi.org/10.3892/etm.2019.7678
Pages: 926-931

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Abstract

Recent years have brought additional data on the benefits of prebiotics and probiotics treatment in patients with atopic dermatitis. This review includes all the articles published in PubMed, Scopus, Embase and Cochrane databases until 05.06.2018. The terms used for the search were ‘prebiotic’, ‘probiotic’, ‘atopic dermatitis’, ‘Severity Scoring of Atopic Dermatitis’, and ‘SCORAD’. There was an increase of the intestinal permeability reported in patients with atopic dermatitis and a reduction of the cutaneous microbiome diversity. Probiotics modulate the general microbiome and immune status by improving the intestinal barrier; these effects can be responsible for reducing allergic phenomenon and atopic dermatitis severity. We have structured the results by age groups as infants, 1-18 years, adults, and also pregnancy and lactation. Literature does not offer yet answers on the issues such as the optimal dosing, duration needed to see beneficial effects, the optimal time to start the treatment; the personalized use of probiotics according to colonic dysbiosis may be associated with better results. However, most randomized controlled trials and meta-analyzes support the administration of probiotics for at least 8 weeks in order to obtain beneficial effects in improving severity scoring of atopic dermatitis.

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