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Article

miR‑876‑5p suppresses breast cancer progression through targeting TFAP2A

  • Authors:
    • Jie Xu
    • Jie Zheng
    • Jian Wang
    • Jianping Shao
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, The Fifth Central Hospital of Tianjin, Tianjin 300450, P.R. China
  • Pages: 1458-1464
    |
    Published online on: June 18, 2019
       https://doi.org/10.3892/etm.2019.7689
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Abstract

MicroRNAs (miRNAs) are widely expressed in human cells and closely associated with various types of cancer, including breast cancer. miR‑876‑5p has been indicated to participate in the tumorigenesis of certain types of cancer, such as hepatocellular carcinoma. Nevertheless, the roles of miR‑876‑5p in breast cancer remain unclear. In the present study, it was revealed that miR‑876‑5p expression levels were decreased in breast cancer cells compared with a normal cell line. miR‑876‑5p ectopic expression suppressed breast cancer cell proliferation and arrested progression of the cell cycle. In addition, miR‑876‑5p suppressed breast cancer cell migration and invasion. miR‑876‑5p was demonstrated to directly target transcription factor AP‑2‑α (TFAP2A) in breast cancer cells, and restoration of TFAP2A rescinded the suppressive role of miR‑876‑5p. In summary, the results from the present study provide evidence that miR‑876‑5p suppresses breast cancer progression by regulating cell proliferation, migration and invasion in a TFAP2A‑dependent manner.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Zhao L and Zheng XY: MicroRNA-490 inhibits tumorigenesis and progression in breast cancer. Onco Targets Ther. 9:4505–4516. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Rudolph A, Chang-Claude J and Schmidt MK: Gene-environment interaction and risk of breast cancer. Br J Cancer. 114:125–133. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Jemal A, Center MM, DeSantis C and Ward EM: Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev. 19:1893–1907. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Liu RZ, Garcia E, Glubrecht DD, Poon HY, Mackey JR and Godbout R: CRABP1 is associated with a poor prognosis in breast cancer: Adding to the complexity of breast cancer cell response to retinoic acid. Mol Cancer. 14:1292015. View Article : Google Scholar : PubMed/NCBI

6 

Dong Y, Chang C, Liu J and Qiang J: Targeting of GIT1 by miR-149* in breast cancer suppresses cell proliferation and metastasis in vitro and tumor growth in vivo. Onco Targets Ther. 10:5873–5882. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Zhu P, Wang Y, Wu J, Huang G, Liu B, Ye B, Du Y, Gao G, Tian Y, He L and Fan Z: LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nat Commun. 7:136082016. View Article : Google Scholar : PubMed/NCBI

8 

Adams BD, Kasinski AL and Slack FJ: Aberrant regulation and function of microRNAs in cancer. Curr Biol. 24:R762–R776. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Liu B, Li J and Cairns MJ: Identifying miRNAs, targets and functions. Brief Bioinform. 15:1–19. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Song B, Lin HX, Dong LL, Ma JJ and Jiang ZG: MicroRNA-338 inhibits proliferation, migration, and invasion of gastric cancer cells by the Wnt/β-catenin signaling pathway. Eur Rev Med Pharmacol Sci. 22:1290–1296. 2018.PubMed/NCBI

11 

Li N, Han M, Zhou N, Tang Y and Tang XS: MicroRNA-495 confers increased sensitivity to chemotherapeutic agents in gastric cancer via the mammalian target of rapamycin (mTOR) signaling pathway by interacting with human epidermal growth factor receptor 2 (ERBB2). Med Sci Monit. 24:5960–5972. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Bai D, Sun H, Wang X, Lou H, Zhang J, Wang X and Jiang L: MiR-150 inhibits cell growth in vitro and in vivo by restraining the RAB11A/WNT/β-catenin pathway in thyroid cancer. Med Sci Monit. 23:4885–4894. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Song L, Dai Z, Zhang S, Zhang H, Liu C, Ma X, Liu D, Zan Y and Yin X: MicroRNA-1179 suppresses cell growth and invasion by targeting sperm-associated antigen 5-mediated Akt signaling in human non-small cell lung cancer. Biochem Biophys Res Commun. 504:164–170. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Li Y, Wang Y, Fan H, Zhang Z and Li N: miR-125b-5p inhibits breast cancer cell proliferation, migration and invasion by targeting KIAA1522. Biochem Biophys Res Commun. 504:277–282. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Dong Y, Zheng Y, Wang C, Ding X, Du Y, Liu L, Zhang W, Zhang W, Zhong Y, Wu Y and Song X: MiR-876-5p modulates head and neck squamous cell carcinoma metastasis and invasion by targeting vimentin. Cancer Cell Int. 18:1212018. View Article : Google Scholar : PubMed/NCBI

16 

Wang Y, Xie Y, Li X, Lin J, Zhang S, Li Z, Huo L and Gong R: MiR-876-5p acts as an inhibitor in hepatocellular carcinoma progression by targeting DNMT3A. Pathol Res Pract. 214:1024–1030. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Bao L, Lv L, Feng J, Chen Y, Wang X, Han S and Zhao H: MiR-876-5p suppresses epithelial-mesenchymal transition of lung cancer by directly down-regulating bone morphogenetic protein 4. J Biosci. 42:671–681. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Nagasawa S, Sedukhina AS, Nakagawa Y, Maeda I, Kubota M, Ohnuma S, Tsugawa K, Ohta T, Roche-Molina M, Bernal JA, et al: LSD1 overexpression is associated with poor prognosis in basal-like breast cancer, and sensitivity to PARP inhibition. PLoS One. 10:e01180022015. View Article : Google Scholar : PubMed/NCBI

20 

Wang Y, Yin W, Lin Y, Yin K, Zhou L, Du Y, Yan T and Lu J: Downregulated circulating microRNAs after surgery: Potential noninvasive biomarkers for diagnosis and prognosis of early breast cancer. Cell Death Discov. 4:212018. View Article : Google Scholar

21 

Xu Q, Zhu Q, Zhou Z, Wang Y, Liu X, Yin G, Tong X and Tu K: MicroRNA-876-5p inhibits epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by targeting BCL6 corepressor like 1. Biomed Pharmacother. 103:645–652. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Xu DX, Guo JJ, Zhu GY, Wu HJ, Zhang QS and Cui T: MiR-363-3p modulates cell growth and invasion in glioma by directly targeting pyruvate dehydrogenase B. Eur Rev Med Pharmacol Sci. 22:5230–5239. 2018.PubMed/NCBI

23 

Rehei AL, Zhang L, Fu YX, Mu WB, Yang DS, Liu Y, Zhou SJ and Younusi A: MicroRNA-214 functions as an oncogene in human osteosarcoma by targeting TRAF3. Eur Rev Med Pharmacol Sci. 22:5156–5164. 2018.PubMed/NCBI

24 

Xu J, Wang F, Wang X, He Z and Zhu X: miRNA-543 promotes cell migration and invasion by targeting SPOP in gastric cancer. Onco Targets Ther. 11:5075–5082. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Zhang Z, Li J, Huang Y, Peng W, Qian W, Gu J, Wang Q, Hu T, Ji D, Ji B, et al: Upregulated miR-1258 regulates cell cycle and inhibits cell proliferation by directly targeting E2F8 in CRC. Cell Prolif. 51:e125052018. View Article : Google Scholar : PubMed/NCBI

26 

Yuan J, Zhang N, Zheng Y, Chen YD, Liu J and Yang M: LncRNA GAS5 indel genetic polymorphism contributes to glioma risk through interfering binding of transcriptional factor TFAP2A. DNA Cell Biol. 37:750–757. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Shi D, Xie F, Zhang Y, Tian Y, Chen W, Fu L, Wang J, Guo W, Kang T, Huang W and Deng W: TFAP2A regulates nasopharyngeal carcinoma growth and survival by targeting HIF-1alpha signaling pathway. Cancer Prev Res (Phila.). 7:266–277. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Allouche A, Nolens G, Tancredi A, Delacroix L, Mardaga J, Fridman V, Winkler R, Boniver J, Delvenne P and Begon DY: The combined immunodetection of AP-2alpha and YY1 transcription factors is associated with ERBB2 gene overexpression in primary breast tumors. Breast Cancer Res. 10:R92008. View Article : Google Scholar : PubMed/NCBI

29 

Yan F, He Q, Hu X, Li W, Wei K, Li L, Zhong Y, Ding X, Xiang S and Zhang J: Direct regulation of caspase3 by the transcription factor AP2α is involved in aspirininduced apoptosis in MDAMB453 breast cancer cells. Mol Med Rep. 7:909–914. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu J, Zheng J, Wang J and Shao J: miR‑876‑5p suppresses breast cancer progression through targeting TFAP2A. Exp Ther Med 18: 1458-1464, 2019.
APA
Xu, J., Zheng, J., Wang, J., & Shao, J. (2019). miR‑876‑5p suppresses breast cancer progression through targeting TFAP2A. Experimental and Therapeutic Medicine, 18, 1458-1464. https://doi.org/10.3892/etm.2019.7689
MLA
Xu, J., Zheng, J., Wang, J., Shao, J."miR‑876‑5p suppresses breast cancer progression through targeting TFAP2A". Experimental and Therapeutic Medicine 18.2 (2019): 1458-1464.
Chicago
Xu, J., Zheng, J., Wang, J., Shao, J."miR‑876‑5p suppresses breast cancer progression through targeting TFAP2A". Experimental and Therapeutic Medicine 18, no. 2 (2019): 1458-1464. https://doi.org/10.3892/etm.2019.7689
Copy and paste a formatted citation
x
Spandidos Publications style
Xu J, Zheng J, Wang J and Shao J: miR‑876‑5p suppresses breast cancer progression through targeting TFAP2A. Exp Ther Med 18: 1458-1464, 2019.
APA
Xu, J., Zheng, J., Wang, J., & Shao, J. (2019). miR‑876‑5p suppresses breast cancer progression through targeting TFAP2A. Experimental and Therapeutic Medicine, 18, 1458-1464. https://doi.org/10.3892/etm.2019.7689
MLA
Xu, J., Zheng, J., Wang, J., Shao, J."miR‑876‑5p suppresses breast cancer progression through targeting TFAP2A". Experimental and Therapeutic Medicine 18.2 (2019): 1458-1464.
Chicago
Xu, J., Zheng, J., Wang, J., Shao, J."miR‑876‑5p suppresses breast cancer progression through targeting TFAP2A". Experimental and Therapeutic Medicine 18, no. 2 (2019): 1458-1464. https://doi.org/10.3892/etm.2019.7689
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