miR‑876‑5p suppresses breast cancer progression through targeting TFAP2A

  • Authors:
    • Jie Xu
    • Jie Zheng
    • Jian Wang
    • Jianping Shao
  • View Affiliations

  • Published online on: June 18, 2019     https://doi.org/10.3892/etm.2019.7689
  • Pages: 1458-1464
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Abstract

MicroRNAs (miRNAs) are widely expressed in human cells and closely associated with various types of cancer, including breast cancer. miR‑876‑5p has been indicated to participate in the tumorigenesis of certain types of cancer, such as hepatocellular carcinoma. Nevertheless, the roles of miR‑876‑5p in breast cancer remain unclear. In the present study, it was revealed that miR‑876‑5p expression levels were decreased in breast cancer cells compared with a normal cell line. miR‑876‑5p ectopic expression suppressed breast cancer cell proliferation and arrested progression of the cell cycle. In addition, miR‑876‑5p suppressed breast cancer cell migration and invasion. miR‑876‑5p was demonstrated to directly target transcription factor AP‑2‑α (TFAP2A) in breast cancer cells, and restoration of TFAP2A rescinded the suppressive role of miR‑876‑5p. In summary, the results from the present study provide evidence that miR‑876‑5p suppresses breast cancer progression by regulating cell proliferation, migration and invasion in a TFAP2A‑dependent manner.
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August-2019
Volume 18 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Xu J, Zheng J, Wang J and Shao J: miR‑876‑5p suppresses breast cancer progression through targeting TFAP2A. Exp Ther Med 18: 1458-1464, 2019
APA
Xu, J., Zheng, J., Wang, J., & Shao, J. (2019). miR‑876‑5p suppresses breast cancer progression through targeting TFAP2A. Experimental and Therapeutic Medicine, 18, 1458-1464. https://doi.org/10.3892/etm.2019.7689
MLA
Xu, J., Zheng, J., Wang, J., Shao, J."miR‑876‑5p suppresses breast cancer progression through targeting TFAP2A". Experimental and Therapeutic Medicine 18.2 (2019): 1458-1464.
Chicago
Xu, J., Zheng, J., Wang, J., Shao, J."miR‑876‑5p suppresses breast cancer progression through targeting TFAP2A". Experimental and Therapeutic Medicine 18, no. 2 (2019): 1458-1464. https://doi.org/10.3892/etm.2019.7689