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Article

Efficacy of vitamin D plus calcium with/without alendronate on bone metabolism in immunologic thrombocytopenic purpura patients with steroid treatment: Nine‑month results of a randomized, double‑blinded, controlled trial

  • Authors:
    • Xia Lin
    • Hui‑Qi Zhang
    • Li‑Hong Shou
    • Xiang‑Li Shen
    • Zong‑Xin Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First People's Hospital of Huzhou, The First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang 313000, P.R. China, Department of Hematology, Huzhou Central Hospital, Huzhou, Zhejiang 313003, P.R. China, Clinical Laboratory, Huzhou Central Hospital, Huzhou, Zhejiang 313003, P.R. China
  • Pages: 1391-1398
    |
    Published online on: June 20, 2019
       https://doi.org/10.3892/etm.2019.7694
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Abstract

Bone loss is a prominent complication in immunologic thrombocytopenic purpura (ITP) patients with steroid treatment. Anti‑osteoporotic medications are applied as a therapeutic strategy to prevent bone deterioration in ITP patients. However, the skeletal protective effect of alendronate (ALN) in ITP patients has been rarely reported. The present study was performed to determine whether ALN reduces bone loss in ITP patients. A total of 40 ITP patients with steroid treatment were randomized into a placebo group [n=20; caltrate D (CalD)] and an ALN (10 mg/day) + CalD group (n=20). The patients received CalD or CalD + ALN treatment for 9 months. The primary outcomes were bone mineral density (BMD) in the lumbar vertebrae (L1‑L4), femoral neck and total hip, as well as bone metabolism markers. The results indicated that the BMD of the lumbar vertebrae (L1‑L4), femoral neck and total hip was significantly increased after ALN + CalD treatment for at 6 and 9 months compared with the baseline. Compared with CalD treatment alone, CalD combined with ALN significantly elevated the BMD at the three skeletal sites at 9 months. Compared with the baseline levels or CalD treatment alone, ALN together with CalD treatment markedly reduced urinary Ca excretion and the serum levels of the bone resorption markers tartrate resistant acid phosphatase 5b and C‑terminal telopeptides of type 1 collagen, at 9 months. In conclusion, treatment with ALN together with CalD significantly elevated the BMD at three skeletal sites, and inhibited urinary Ca excretion and the activity of bone resorption markers in patients with ITP.
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1 

Sciascia S, Mompean E, Radin M, Roccatello D and Cuadrado MJ: Rate of adverse effects of medium- to high-dose glucocorticoid therapy in systemic lupus erythematosus: A systematic review of randomized control trials. Clin Drug Investig. 37:519–524. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Safy M, de Hair MJH, Jacobs JWG, Buttgereit F, Kraan MC and van Laar JM: Efficacy and safety of selective glucocorticoid receptor modulators in comparison to glucocorticoids in arthritis, a systematic review. PLoS One. 12:e01888102017. View Article : Google Scholar : PubMed/NCBI

3 

Rodeghiero F and Ruggeri M: ITP and international guidelines: What do we know, what do we need? Presse Med. 43:e61–e67. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Rentero ML, Amigo E, Chozas N, Fernández Prada M, Silva-Fernández L, Abad Hernandez MA, Rodriguez Barrera JM and del Pino-Montes J; GHDP study group, : Prevalence of fractures in women with rheumatoid arthritis and/or systemic lupus erythematosus on chronic glucocorticoid therapy. BMC Musculoskelet Disord. 16:3002015. View Article : Google Scholar : PubMed/NCBI

5 

Robinson DE, Dennison EM, Cooper C, van Staa TP and Dixon WG: A review of the methods used to define glucocorticoid exposure and risk attribution when investigating the risk of fracture in a rheumatoid arthritis population. Bone. 90:107–115. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Rizzoli R and Biver E: Glucocorticoid-induced osteoporosis: Who to treat with what agent? Nat Rev Rheumatol. 11:98–109. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Compston J: Glucocorticoid-induced osteoporosis: An update. Endocrine. 61:7–16. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Kanis JA, Johansson H, Oden A, Johnell O, de Laet C, Melton III LJ, Tenenhouse A, Reeve J, Silman AJ, Pols HA, et al: A meta-analysis of prior corticosteroid use and fracture risk. J Bone Miner Res. 19:893–899. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Sugiura T, Yamamoto K, Murakami K, Horita S, Matsusue Y, Nakashima C and Kirita T: Immune thrombocytopenic purpura detected with oral Hemorrhage: A case report. J Dent (Shiraz). 19:159–163. 2018.PubMed/NCBI

10 

Neunert C, Lim W, Crowther M, Cohen A, Solberg L Jr and Crowther MA; American Society of Hematology, : The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood. 117:4190–4207. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P, Bussel JB, Chong BH, Cines DB, Gernsheimer TB, Godeau B, et al: International consensus report on the investigation and management of primary immune thrombocytopenia. Blood. 115:168–186. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Nomura S, Kurata Y, Tomiyama Y, Takubo T, Hasegawa M, Saigo K, Nishikawa M, Higasa S, Maeda Y and Hayashi K: Effects of bisphosphonate administration on the bone mass in immune thrombocytopenic purpura patients under treatment with steroids. Clin Appl Thromb Hemost. 16:622–627. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Sambrook PN, Kotowicz M, Nash P, Styles CB, Naganathan V, Henderson-Briffa KN, Eisman JA and Nicholson GC: Prevention and treatment of glucocorticoid-induced osteoporosis: A comparison of calcitriol, vitamin D plus calcium, and alendronate plus calcium. J Bone Miner Res. 18:919–924. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Cesareo R, Di Stasio E, Vescini F, Campagna G, Cianni R, Pasqualini V, Romitelli F, Grimaldi F, Manfrini S and Palermo A: Effects of alendronate and vitamin D in patients with normocalcemic primary hyperparathyroidism. Osteoporos Int. 26:1295–1302. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Li G, Lv CA, Tian L, Jin LJ and Zhao W: A retrospective study of alendronate for the treatment of ankylosing spondylitis. Medicine (Baltimore). 97:e107382018. View Article : Google Scholar : PubMed/NCBI

16 

Millonig G, Graziadei IW, Eichler D, Pfeiffer KP, Finkenstedt G, Muehllechner P, Koenigsrainer A, Margreiter R and Vogel W: Alendronate in combination with calcium and vitamin D prevents bone loss after orthotopic liver transplantation: A prospective single-center study. Liver Transpl. 11:960–966. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Shapses SA, Kendler DL, Robson R, Hansen KE, Sherrell RM, Field MP, Woolf E, Berd Y, Mantz AM and Santora AC II: Effect of alendronate and vitamin D3 on fractional calcium absorption in a double-blind, randomized, placebo-controlled trial in postmenopausal osteoporotic women. J Bone Miner Res. 26:1836–1844. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Siris ES, Adler R, Bilezikian J, Bolognese M, Dawson-Hughes B, Favus MJ, Harris ST, Jan de Beur SM, Khosla S, Lane NE, et al: The clinical diagnosis of osteoporosis: A position statement from the National Bone Health Alliance Working Group. Osteoporos Int. 25:1439–1443. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Hasegawa M, Nisikawa M, Nomura S, Takubo T, Suehiro A, Saigo K, Hayashi K, Tamaki S, Mizutani M, Uemura Y and Kurata Y; Kinki ITP Cooperative Study Group, : Effect of glucocorticoids on bone mineral density in patients with idiopathic thrombocytopenic purpura. Rinsho Ketsueki. 46:121–126. 2005.(In Japanese). PubMed/NCBI

20 

Liao EY, Zhang ZL, Xia WB, Lin H, Cheng Q, Wang L, Hao YQ, Chen DC, Tang H, Peng YD, et al: Calcifediol (25-hydroxyvitamin D) improvement and calcium-phosphate metabolism of alendronate sodium/vitamin D3 combination in Chinese women with postmenopausal osteoporosis: A post hoc efficacy analysis and safety reappraisal. BMC Musculoskelet Disord. 19:2102018. View Article : Google Scholar : PubMed/NCBI

21 

Yang L, Tian JH, He ZY, Tang XL and Yang KH: A Meta-analysis of alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis. Zhonghua Nei Ke Za Zhi. 52:838–843. 2013.(In Chinese). PubMed/NCBI

22 

D'Amelio P, Grimaldi A, Cristofaro MA, Ravazzoli M, Molinatti PA, Pescarmona GP and Isaia GC: Alendronate reduces osteoclast precursors in osteoporosis. Osteoporos Int. 21:1741–1750. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Bradaschia-Correa V, Moreira MM and Arana-Chavez VE: Reduced RANKL expression impedes osteoclast activation and tooth eruption in alendronate-treated rats. Cell Tissue Res. 353:79–86. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Martins CA, Leyhausen G, Volk J and Geurtsen W: Effects of alendronate on osteoclast formation and activity in vitro. J Endod. 41:45–49. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Zhang Q, Badell IR, Schwarz EM, Boulukos KE, Yao Z, Boyce BF and Xing L: Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2. Arthritis Rheum. 52:2708–2718. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Siebelt M, Waarsing JH, Groen HC, Müller C, Koelewijn SJ, de Blois E, Verhaar JA, de Jong M and Weinans H: Inhibited osteoclastic bone resorption through alendronate treatment in rats reduces severe osteoarthritis progression. Bone. 66:163–170. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Iseri K, Iyoda M, Watanabe M, Matsumoto K, Sanada D, Inoue T, Tachibana S and Shibata T: The effects of denosumab and alendronate on glucocorticoid-induced osteoporosis in patients with glomerular disease: A randomized, controlled trial. PLoS One. 13:e01938462018. View Article : Google Scholar : PubMed/NCBI

28 

Boyce AM, Kelly MH, Brillante BA, Kushner H, Wientroub S, Riminucci M, Bianco P, Robey PG and Collins MT: A randomized, double blind, placebo-controlled trial of alendronate treatment for fibrous dysplasia of bone. J Clin Endocrinol Metab. 99:4133–4140. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lin X, Zhang HQ, Shou LH, Shen XL and Zhang ZX: Efficacy of vitamin D plus calcium with/without alendronate on bone metabolism in immunologic thrombocytopenic purpura patients with steroid treatment: Nine‑month results of a randomized, double‑blinded, controlled trial. Exp Ther Med 18: 1391-1398, 2019.
APA
Lin, X., Zhang, H., Shou, L., Shen, X., & Zhang, Z. (2019). Efficacy of vitamin D plus calcium with/without alendronate on bone metabolism in immunologic thrombocytopenic purpura patients with steroid treatment: Nine‑month results of a randomized, double‑blinded, controlled trial. Experimental and Therapeutic Medicine, 18, 1391-1398. https://doi.org/10.3892/etm.2019.7694
MLA
Lin, X., Zhang, H., Shou, L., Shen, X., Zhang, Z."Efficacy of vitamin D plus calcium with/without alendronate on bone metabolism in immunologic thrombocytopenic purpura patients with steroid treatment: Nine‑month results of a randomized, double‑blinded, controlled trial". Experimental and Therapeutic Medicine 18.2 (2019): 1391-1398.
Chicago
Lin, X., Zhang, H., Shou, L., Shen, X., Zhang, Z."Efficacy of vitamin D plus calcium with/without alendronate on bone metabolism in immunologic thrombocytopenic purpura patients with steroid treatment: Nine‑month results of a randomized, double‑blinded, controlled trial". Experimental and Therapeutic Medicine 18, no. 2 (2019): 1391-1398. https://doi.org/10.3892/etm.2019.7694
Copy and paste a formatted citation
x
Spandidos Publications style
Lin X, Zhang HQ, Shou LH, Shen XL and Zhang ZX: Efficacy of vitamin D plus calcium with/without alendronate on bone metabolism in immunologic thrombocytopenic purpura patients with steroid treatment: Nine‑month results of a randomized, double‑blinded, controlled trial. Exp Ther Med 18: 1391-1398, 2019.
APA
Lin, X., Zhang, H., Shou, L., Shen, X., & Zhang, Z. (2019). Efficacy of vitamin D plus calcium with/without alendronate on bone metabolism in immunologic thrombocytopenic purpura patients with steroid treatment: Nine‑month results of a randomized, double‑blinded, controlled trial. Experimental and Therapeutic Medicine, 18, 1391-1398. https://doi.org/10.3892/etm.2019.7694
MLA
Lin, X., Zhang, H., Shou, L., Shen, X., Zhang, Z."Efficacy of vitamin D plus calcium with/without alendronate on bone metabolism in immunologic thrombocytopenic purpura patients with steroid treatment: Nine‑month results of a randomized, double‑blinded, controlled trial". Experimental and Therapeutic Medicine 18.2 (2019): 1391-1398.
Chicago
Lin, X., Zhang, H., Shou, L., Shen, X., Zhang, Z."Efficacy of vitamin D plus calcium with/without alendronate on bone metabolism in immunologic thrombocytopenic purpura patients with steroid treatment: Nine‑month results of a randomized, double‑blinded, controlled trial". Experimental and Therapeutic Medicine 18, no. 2 (2019): 1391-1398. https://doi.org/10.3892/etm.2019.7694
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