Open Access

Clinical value of interferon‑γ release assay in the diagnosis of active tuberculosis

  • Authors:
    • Lu Ai
    • Pinning Feng
    • Dubo Chen
    • Shaoqian Chen
    • Hongxu Xu
  • View Affiliations

  • Published online on: June 21, 2019     https://doi.org/10.3892/etm.2019.7696
  • Pages: 1253-1257
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Abstract

Sensitivity and specificity of the interferon‑γ release test for active tuberculosis screening were evaluated. Due to the high‑test cost of imported IGRAs, QFT‑GIT and T‑SPOT.TB, we applied a cheaper domestic TB‑IGRA which was approved in China recently. We recruited 740 patients and performed tuberculosis interferon release test (IGRAs), detection of Mycobacterium tuberculosis IgG antibody (TB‑IgG) and tuberculin skin test (TST). The sensitivity of the three methods are 90.8, 40.0 and 75.45%, with specificity of 76.62, 74.47 and 72.27%. The area under the ROC curve according to the value of T‑N detected by IGRAs was 0.878 (95% CI, 0.839‑0.917), with the area under the curve for the diagnosis of active pulmonary tuberculosis and extrapulmonary tuberculosis being 0.839 and 0.841 respectively. The interferon‑γ release test seems to be superior to TST and TB‑IgG as a screening tool for the detection of active tuberculosis in China.
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August-2019
Volume 18 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ai L, Feng P, Chen D, Chen S and Xu H: Clinical value of interferon‑γ release assay in the diagnosis of active tuberculosis. Exp Ther Med 18: 1253-1257, 2019
APA
Ai, L., Feng, P., Chen, D., Chen, S., & Xu, H. (2019). Clinical value of interferon‑γ release assay in the diagnosis of active tuberculosis. Experimental and Therapeutic Medicine, 18, 1253-1257. https://doi.org/10.3892/etm.2019.7696
MLA
Ai, L., Feng, P., Chen, D., Chen, S., Xu, H."Clinical value of interferon‑γ release assay in the diagnosis of active tuberculosis". Experimental and Therapeutic Medicine 18.2 (2019): 1253-1257.
Chicago
Ai, L., Feng, P., Chen, D., Chen, S., Xu, H."Clinical value of interferon‑γ release assay in the diagnosis of active tuberculosis". Experimental and Therapeutic Medicine 18, no. 2 (2019): 1253-1257. https://doi.org/10.3892/etm.2019.7696