Clinical value of interferon‑γ release assay in the diagnosis of active tuberculosis

Ai,Lu; Feng,Pinning; Chen,Dubo; Chen,Shaoqian; Xu,Hongxu

doi:10.3892/etm.2019.7696

August-2019 Volume 18 Issue 2

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August-2019 Volume 18 Issue 2

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Clinical value of interferon‑γ release assay in the diagnosis of active tuberculosis

Authors:
- Lu Ai
- Pinning Feng
- Dubo Chen
- Shaoqian Chen
- Hongxu Xu
View Affiliations / Copyright

Affiliations: Department of Clinical Laboratory, The First Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China
Pages: 1253-1257
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Published online on: June 21, 2019

https://doi.org/10.3892/etm.2019.7696
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Abstract

Sensitivity and specificity of the interferon‑γ release test for active tuberculosis screening were evaluated. Due to the high‑test cost of imported IGRAs, QFT‑GIT and T‑SPOT.TB, we applied a cheaper domestic TB‑IGRA which was approved in China recently. We recruited 740 patients and performed tuberculosis interferon release test (IGRAs), detection of Mycobacterium tuberculosis IgG antibody (TB‑IgG) and tuberculin skin test (TST). The sensitivity of the three methods are 90.8, 40.0 and 75.45%, with specificity of 76.62, 74.47 and 72.27%. The area under the ROC curve according to the value of T‑N detected by IGRAs was 0.878 (95% CI, 0.839‑0.917), with the area under the curve for the diagnosis of active pulmonary tuberculosis and extrapulmonary tuberculosis being 0.839 and 0.841 respectively. The interferon‑γ release test seems to be superior to TST and TB‑IgG as a screening tool for the detection of active tuberculosis in China.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical value of interferon‑γ release assay in the diagnosis of active tuberculosis

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